McMaster University

McMaster University

PediCRaFT: Pediatric Crohn's Disease Fecal Transplant Trial (PediCRaFT)

PediCRaFT: Pediatric Crohn's Disease Fecal Transplant Trial (PediCRaFT)

PediCRaFT: Pediatric Crohn's Disease Fecal Transplant Trial (PediCRaFT) is one of the first paediatric faecal transplant study for inflammatory bowel disease in Canada. The trial is being led by Dr. Nikhil Pai, and supported by the Division of Paediatric Gastroenterology and Nutrition at McMaster Children’s Hospital. Study collaborators include Dr. Christine Lee (Division of Infectious Disease at St. Joseph's Hospital in Hamilton), Dr. Paul Moayyedi (Division of Adult Gastroenterology at McMaster University), with support from the Farncombe Digestive Disease Research Institute at McMaster University.

What's Involved?

The PediCRaFT study is a double blind, placebo controlled, randomized controlled trial. Participants will come to the McMaster Children’s Hospital 3E Clinic where they will receive a faecal retention enema containing live, safety screened, human donor stool, or a placebo containing normal saline. Following the enema, participants will receive oral capsules containing either safety screened, human donor stool, or a placebo containing dextrose (sugar pill) over the course of six weeks. The oral capsules can be taken at home. Patients will remain on their existing medications and current doses for the duration of the trial.

Clinic Location:

PediCRaFT Research Trial
3E Clinic (3rd Floor)
McMaster Children's Hospital
1200 Main Street West
Hamilton, Ontario

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