McMaster University

McMaster University

Anthony Chan

Dr. Anthony Chan

Dr. Anthony Chan graduated from medical school at the University of Hong Kong in 1987. After an internship and brief training in Nuclear Medicine, he began his pediatric career in 1989 at the University of Hong Kong and, subsequently, at the University of Saskatchewan.  Dr. Chan completed his clinical training in pediatric hematology and oncology at the Hospital for Sick Children in 1995. Dr. Chan joined McMaster University in 1993 as a research fellow and moved to The Hospital for Sick Children from 2000 - 2001. He rejoined McMaster University in July 2001 and has been a full professor in the Department of Pediatrics since 2005.
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Dr. Chan's main research interest is in the study of the hemostatic system in the young and hemostatic mechanisms related to pediatric diseases. Currently, Dr. Chan is developing a family of novel serpin-glycosaminoglycan covalent complexes. The study of these compounds will further understanding of the mechanisms of action of glycosaminoglycans (eg. Heparin) with serpins (eg. Antithrombin). These compounds are potentially useful in the treatment and prevention of diseases. Potential uses of these compounds includes coating of biomaterials to render them less thrombogenic and, thus, prevent some thromboembolic diseases. In addition to treatment of thrombosis with these novel anticoagulants, Dr. Chan has co-invented a methodology for monitoring thrombin generation potential in the patient samples. Dr. Chan is very involved with clinical research/clinical trials in pediatric thrombosis and hemophilia, and pediatric stroke.

Dr. Chan's clinical focus is on children with bleeding and clotting disorders. He is the director of the Hamilton-Niagara Regional Hemophilia Program, and he also provides a free consultation services for physicians who look after children with thrombosis through a 1-800 number (1-800-NO-CLOTS). He is the division head for hematology/oncology and Associate Chair of Research in the Department of Pediatrics at McMaster University.

Dr. Chan's research is frequently published in peer-reviewed publications in leading journals. A comprehensive list of publications is available on Research Gate.

Current Projects

  • Surface Mechanisms of Anticoagulant ATH Complex
  • Study of Pathogenesis and Treatment of Pediatric Diseases Related to the Hemostatic System
  • Changes in glycosylation of coagulation factors during childhood development

Publications & Achievements

  • Creation and development of a novel anticoagulant ATH covalent complex, potentially for use as a pulmonary/systemic anticoagulant or surface coating for catheters.
  • Invention of a new clinical assay system to directly monitor thrombin generation in patient plasma/blood to aid in assessing clinical conditions and treatments.
  • Maintenance of a worldwide pediatric thrombophilia consultation service (1800NOCLOTS) to provide information on pediatric thrombosis for physicians.


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