Edward Young

, PhD, FCACB

Professor Emeritus, Pathology and Molecular Medicine

Division: Clinical Pathology

Thrombosis and Atherosclerosis Research Institute (TAARI)
David Braley Research Institute C4-123
Hamilton General Hospital
Hamilton, Ontario
905-521-2100 ext. 40739

younge@taari.ca

Currently accepting Graduate Students

Education and Professional Standing

• FCACB, 1984
• PhD Physiology, University of Toronto, 1977
• MSc Physiology, University of Toronto, 1972

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Interests

Research Focus

• Hemostasis and thrombosis, anticoagulants.
• Biological effects of heparin and related molecules.
• The characterization and role of heparin-binding proteins.
• The pharmacokinetics and pharmacodynamics of heparin and low molecular weight heparins.
• The development of novel anticoagulants.
• The anti-inflammatory effects of low molecular weight heparin and heparinoids lacking anticoagulant activity.

Extensive use of biochemical techniques

• gel and affinity chromatography;
• gel electrophoresis;
• coagulation assays;
• use of radiolabeled tracers;
• small animal and cell culture model

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Selected Publications

• Hill SA, Cleve R, Carlisle E, Young E, McQueen MJ. Intra-individual variability in troponin T concentration in dialysis patients. Clin Biochem 2009; 42:991-995.
• Kavsak PA, Lee A, Hirte H, Young E, Gauldie J. Cytokine elevations in acute coronary syndrome and ovarian cancer: a mechanism for the up-regulation of the acute phase proteins in these different disease etiologies. Clin Biochem 2008; 41: 607-610. 
• Young E. The anti-inflammatory effects of heparin and related compounds. Thromb Res 2008; 122:743-752.
• Oremus M, Hanson M, Whitlock R, Young E, Gupta A, Dal Cin A, Archer C, Raina P. A systematic review of the uses of heparin to treat burn injury. J. Burn Care and Research 2007; 28:794-804.
• Rich JD, Maraganore JM, Young E, Lidon RM, Adelman B, Bourdon P, Charenkavanich S, Hirsh J, Theroux P, Cannon CP. Heparin resistance in acute coronary syndromes. J. Thromb Thrombolysis 2007; 23:93-100.
• Whitlock RP, Young E, Noora J, Farrokhyar F, Blackhall M, Teoh KH. Pulse low dose steroids attenuate post-cardiopulmonary bypass SIRS; SIRS 1. J. Surg Res 2006; 132:188-194.
• Paparella D, Al Radi OO, Meng QH, Venner T, Teoh K, Young E. The effects of high-dose heparin on inflammatory and coagulation parameters following cardiopulmonary bypass. Blood Coagul Fibrinolysis 2005; 16:323-328.
• Whitlock RP, Rubens FD, Young E, Teoh K. Pro: Steroids should be used for cardiopulmonary bypass. J. Cardiothorac Vasc Anesth 2005; 19:250-254.