McMaster University

McMaster University

Zhou Xing

, MD, PhD

Professor, Pathology and Molecular Medicine

Division: Molecular Medicine
McMaster Immunology Research Centre

McMaster University
4012 Michael G. DeGroote Centre for Learning and Discovery
905-525-9140 ext. 22471, 22354
xingz@mcmaster.ca

Assistant: Michelle Allan

Currently accepting Graduate Students
Currently accepting Post Doctoral Fellows

Zhou Xing

Faculty Biography

Education and Professional Standing

  • PhD Immunology, McMaster University, 1993
  • MSc Pathology, Tongji Medical University, 1985
  • MD, North Sichuan Medical College, 1981

Interests

Research Focus

Dr. Xing is Professor in the Department of Pathology and Molecular Medicine. He was a Scholar of the Medical Research Council of Canada and a recipient of Ontario Premier’s Research Excellence Award. Dr. Xing is an expert in anti-microbial immunity, infectious diseases, tuberculosis vaccine development and cytokine biology. His research was or is currently supported by the Canadian Institutes for Health Research, National Institutes of Health (USA), Canadian Foundation for Innovation, World Health Organization and Ontario Thoracic Society.

Our research endeavours center on studies aiming to investigate:

  • Cellular and molecular immune mechanisms of host defense against both acute and chronic infectious diseases including those caused by Gram-negative bacteria, mycobacteria and viruses
  • Modulation of host defense by transgene expression of cytokines and other immune modulatory molecules
  • Immune protection from tuberculosis by a new generation of vaccines including attenuated organism-based, bacterial plasmid DNA-based and viral-based vaccines.

These studies are being carried out primarily in mouse models of sepsis, acute lung inflammation, Gram-negative bacterial infection, viral pneumonia, mycobacterial infection and tuberculosis. We have a special interest in understanding the role of dendritic cells, macrophages and T cells at the cellular level, and of cytokines, cytokine receptors and other transmembrane immunoreceptors at the molecular level, in anti-microbial immunity. Since we are constantly exposing to multiple microbes at the same time, we also pay attention to the immune mechanisms of host responses to heterologous infections. We strive to apply such knowledge to the rational design of tuberculosis vaccines and are currently running a phase clinical trial to evaluate our novel TB vaccine product.

Academic Interests

Dr. Xing is involved in teaching at both the Undergraduate and Graduate level within the Faculty of Health Sciences, including instruction in the following classes:

Undergraduate Studies

  • Bachelor of Health Sciences Program, HTH SCI 3H03, Inquiry III
  • BIOLOGY 4P03, Medical Microbiology
  • BIOCHEM/HTH SCI 4J03, Biochemical Immunology

Graduate Studies, Medical Sciences Program

  • MS715, Advanced Immunobiology I
  • MS716, Advanced Immunobiology II
  • MS717, Vaccines and Vaccine Immunology

 

Selected Publications

See publications here

Team Members

See team members here

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