Theodore E. Warkentin

, MD, FACP, FRCPC

Professor, Pathology and Molecular Medicine

Division: Clinical Pathology

Associate Member, Medicine

Hamilton General Hospital, 1-270B
Hamilton, Ontario
905-527-0271 ext. 46140/46139
twarken@mcmaster.ca

Assistant: Maria Adamek

Education and Professional Standing

• FACP (American College of Physicians), 1992
• FRCPC Hematology, 1988
• FRCPC Internal Medicine, 1987
• MD, University of Manitoba 1983

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Interests

Research Focus

To characterize the pathophysiology, frequency, clinical presentation, diagnostic testing, and treatment of heparin-induced thrombocytopenia.

To characterize the pathophysiology, frequency, clinical presentation, diagnostic testing, and treatment of bleeding gastrointestinal angiodysplasia associated with cardiovascular disease.

Clinical Focus

Dr. Warkentin’s clinical focus includes:

• Inpatient thrombocytopenia
• Transfusion medicine

Academic Interests

Dr. Warkentin is responsible for haematology training of anaesthesia residents. 

 

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Team Members

Technologist

Jo-Ann Sheppard

Selected Publications

Articles

• Warkentin TE. How I diagnose and manage heparin-induced thrombocytopenia. Hematology Am Soc Hematol Educ Program 2011; 2011: 143-149.
• McFarlane A, Warkentin TE, Cartin W. A novel sickling hemoglobinopathy. N Engl J Med 2011; 365: 1548-1549.
• Warkentin TE, Davidson BL, Büller HR, et al. Prevalence and risk of preexisting heparin-induced thrombocytopenia antibodies in patients with acute VTE. Chest 2011; 140: 366-373.
• Warkentin TE, Cook RJ, Marder VJ, Greinacher A. Anti-PF4/heparin antibody formation post-orthopedic surgery thromboprophylaxis: the role of non-drug risk factors and evidence for a stoichiometry-based model of immunization. J Thromb Haemost 2010; 8: 504-512.
• Warkentin TE, Greinacher A. Heparin-induced anaphylactic and anaphylactoid reactions: two distinct but overlapping syndromes. Expert Opin Drug Saf 2009; 8: 129-144.
• Warkentin TE, Sheppard JI, Moore JC, Cook RJ, Kelton JG. Studies of the immune response in heparin-induced thrombocytopenia. Blood 2009; 113: 4963-4969
• Greinacher A, Warkentin TE. Contaminated heparin. N Engl J Med 2008; 359: 1291-1292.
• Warkentin TE, Makris M, Jay RM, Kelton JG. A spontaneous prothrombotic disorder resembling heparin-induced thrombocytopenia. Am J Med 2008; 121: 632-636.
• Warkentin TE, Greinacher A, Koster A, Lincoff AM. Treatment and prevention of heparin-induced thrombocytopenia. American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 2008; 133 (6 Suppl.): 340S-380S.
• Warkentin TE. Drug-induced immune-mediated thrombocytopenia—from purpura to thrombosis. N Engl J Med 2007;356: 891-893.
• Warkentin TE, Moore JC, Morgan DG. Resolution of bleeding from gastrointestinal angiodysplasia and von Willebrand syndrome type 2A after aortic valve replacement. N Engl J Med 2002; 347: 858-859.
• Warkentin TE, Kelton JG. Delayed-onset heparin-induced thrombocytopenia and thrombosis. Ann Intern Med 2001; 135: 502-506.
• Warkentin TE. Venous limb gangrene during warfarin treatment of cancer-associated deep venous thrombosis. Ann Intern Med 2001; 135: 589-593.
• Warkentin TE, Kelton JG. Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med 2001; 344: 1286-1292.
• Warkentin TE, Levine MN, Hirsh J, et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 1995; 332: 1330-1335.

Book Chapters

• Warkentin TE, Warkentin AE. Acquired thrombocyto-penia. In: Concise guide to hematology.Schmaier AH, Lazarus HM, eds. Oxford: Blackwell Publishing Ltd, 2012: 154-173.
• Warkentin TE. Acquired coagulation disorders. In: Warrell DA, Cox TM, Firth JD, eds. Oxford Textbook of Medicine, 5th edn. Oxford: Oxford University Press, 2010: 4531-4546.
• Warkentin TE. Thrombocytopenia due to platelet destruction and hypersplenism (Chap 140). In: Hoffman R, Benz EJ Jr, Shattil SJ, Furie B, Silberstein LE, McGlave P, Heslop H, eds. Hematology: Basic Principles and Practice, 5th edn. Philadelphia: Churchill Livingstone Elsevier, 2009: 2113-2131.

Books

• Warkentin TE, Greinacher A, eds. Heparin-Induced Thrombocytopenia, 4th edn. New York, Informa Healthcare USA, 2007.