Shangguo Tang

, MD, FRCPC, FCAP, FASCP

Assistant Professor, Pathology and Molecular Medicine

Division: Anatomical Pathology

Juravinski Hospital
Hamilton, Ontario
905-527-4322 ext. 42019
tangsh@hhsc.ca

Education and Professional Standing

• FRCPC, Anatomical Pathology, 2007
• FCAP, 2005 FASCP, 2005
• Cytopathology Fellowship, Hahnemann University Hospital, Drexel University, 2005-2006
• Residency, Combined Anatomical/Clinical Pathology Program,  Hahnemann University Hospital, Drexel University, 2001-2005
• MD, Luzhou Medical College, Sichuan, China, 1983
• MSc, West China University of Medical Sciences, Chengdu, Sichuan, China, 1987

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Interests

Clinical and Research Focus

As an Anatomical Pathologist, Dr. Tang provides service through the Hamilton Regional Laboratory Medicine Program. His special interests include cytopathology, breast pathology and gynecologic pathology.  Currently, Dr. Tang is actively involved in clinical research of gynecologic malignancy. 

Dr. Tang's research interests are in cytopathology and breast/gynecological malignancy. Recently, Dr. Tang also has established a collaborator relationship with Dr. Ping-Chang Yang, Intestinal Diseases Research Program, at St Joseph’s Healthcare, and is involved in a research program focusing on understanding the pathogenesis of inflammatory bowel diseases and food allergic reaction in intestine.

Academic Interests

As a resident site supervisor at Henderson General Hospital, Dr. Tang is actively involved in the Undergraduate (MD) and Postgraduate Medicine Educational Programs.  He also acts as supervisor to undergraduate students working on summer research projects. 

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Selected Publications

• Yang SB; Chen X; Wu BY; Wang MW; Cai CH; Cho DB; Chong J; Li P; Tang SG; Yang PC. 2009. Immunoglobulin kappa and immunoglobulin lambda are required for expression of the anti-apoptotic molecule Bcl-xL in human colorectal cancer tissue.  Scand J Gastroenterol 44 (12): 1443–1451
• Zheng PY, Feng BS, Oluwole C, Struiksma S, Chen X, Li P, Tang SG, Yang PC. 2009.  Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine. Gut. 58(11):1473-9.
• Feng BS, Chen X, Li P, ZhengPY, Chong J, Cho DB, He SH, Tang SG, Yang PC. 2009. Expression of integrin alphavbeta6 in the intestinal epithelial cells of patients with inflammatory bowel disease.  North Am J Med Sci 1: 200-204
• Chen X, Feng BS, Zheng PY, Liao XQ, Chong J, Tang SG and Yang PC. 2008. Fc gamma receptor signaling in mast cells links microbial stimulation to mucosal immune inflammation in the intestine. Am J pathology 173 (6): 1647-1656.
• Tang S, Le-Tien H, Goldstein BJ, Shin P, Lai R, and Fantus, IG. 2001. Decreased in situ insulin receptor dephosphorylation in hyperglycemia-induced insulin resistance in rat adipocytes. Diabetes. 50(1):83-90.
• Tang S, Beharry S, Kent G and Durie PR. 1999. Synergistic effects of cyclic AMP- and calcium-mediated amylase secretion in isolated pancreatic acini from cystic fibrosis mice. Pediatr Res 45(4):482-488.
• Tang S, Lu B, and Fantus IG. 1998. Stimulation of 125I-transferrin binding and 59Fe uptake in rat adipocytes by vanadate: Treatment time determines apparent tissue sensitivity. Metabolism 47(6):630-636.
• Tang S, Beharry S and Durie PR. 1997. Postnatal development of the rat exocrine pancreas. I. Alterations in high- and low-affinity cholecystokinin receptors and enzyme secretion. Pancreas 15:325-334.
• Tang S, Beharry S and Durie PR. 1997. Postnatal development of the rat exocrine pancreas. II. Effects of protein-calorie malnutrition on amylase secretion and CCK receptor binding. Pancreas 15:335-344.
• Fantus IG, George R, Tang S, Chong P and Poznansky MJ. 1996. The insulin-mimetic agent vanadate promotes receptor endocytosis and inhibits intracellular ligand-receptor degradation by a mechanism distinct from the lysosomotropic agents. Diabetes 45:1084-1093.
• Fantus IG, Deragon G, Lai R and Tang S. 1995. Modulation of insulin action by vanadate: evidence of a role for phosphotyrosine phosphatase activity to alter cellular signaling. Mol Cell Biochem 153:103-112.