McMaster University

Gurmit Singh

, PhD

Professor, Pathology and Molecular Medicine

Division: Molecular Medicine

Associate Member, Biochemistry and Biomedical Sciences
Senior Scientist, Cancer Care Ontario

2102 Michael G DeGroote Centre for Learning and Discovery
Hamilton, Ontario
905-525-9140 ext. 28144
singhg@mcmaster.ca

Assistant: Sharon Ralph

Currently accepting Graduate Students
Currently accepting Post Doctoral Fellows

Gurmit Singh

Faculty Biography

Education and Professional Standing

  • PhD Pharmacology, Dalhousie University, 1982
  • BSc Biochemistry, Dalhousie University, 1977

Interests

General

  • Experimental Cancer Therapy for breast and prostate cancer

Specific

  • Mitochondria as a target for cancer chemotherapy
  • Strategies to modulate bone metastasis
  • Molecular and cellular mechanisms of photodynamic therapy

Selected Links


Team Members

Post-Doctoral Students

Drs. S Bahzad, J. Djiometio, M. Kilemade, J. Lemon, Z. Saikali

Students

R. Cowan, D. Hamelinck, S. Hopmans, H. Lin., E. Seidlitz, M. Sharma, R. Sharma

Selected Publications

  • Duivenvoorden WC, Vukmirovic-Popovic S, Kalina M, Seidlitz E, Singh G. (2007).  Effect of zoledronic acid on the doxycycline-induced decrease in tumour burden in a bone metastasis model of human breast cancer. British Journal of Cancer, 96(10): 1526-1531.
  • Wilson, LA., Gemin, A., Espiritu, R., Singh G.  (2005) ets-1 is transcriptionally up-regulated by H202 via an antioxidant response element.  FASEB J.  19 (14): 2085-7.
  • Khalilli, P., Arakelian, A. Chen, G. Singh, G., and Rabbani, S.A. (2005)  Effect of Herceptin on the development and progression of skeletal metastases in a xenograft model of human breast cancer.  Oncogene. 24 (44): 6657-66.
  • Preston, T.J., Woodgett, J.R. and Singh, G.  (2003) JNK1 activity modulates cellular growth arrest response to catalase-mediated scavenging of H2O2.  Exp. Cell. Res. 285(1):146-58.
  • Vukmirovic-Popovic S., Colterjohn N., Lhotak S., Duivenvoorden W.C.M., Orr F.W., Singh G. (2002) Morphological, histomorphometric, and microstructural alterations in human bone metastasis from breast carcinoma.  Bone, 31(4):529-535.
  • Preston T.J., Singh G. (2001) Scavenging of extracellular H2O2 by catalase inhibits the proliferation of HER-2/Neu-transformed Rat-1 fibroblasts through the induction of a stress response. J Biol Chem, 276(12): 9558-9564.

Books Edited

  • 2005. Bone Metastasis: Experimental and Clinical Therapeutics (Cancer Drug Discovery and Development Series) (Invited Editors, Singh G., Rabbani, S.) Humana Press, NJ, USA
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