McMaster University

McMaster University

Gurmit Singh

, PhD

Professor, Pathology and Molecular Medicine

Division: Molecular Medicine

Associate Member, Biochemistry and Biomedical Sciences
Senior Scientist, Cancer Care Ontario

2102 Michael G DeGroote Centre for Learning and Discovery
Hamilton, Ontario
905-525-9140 ext. 28144
singhg@mcmaster.ca

Assistant: Sharon Ralph

Currently accepting Graduate Students
Currently accepting Post Doctoral Fellows

Gurmit Singh

Faculty Biography

Education and Professional Standing

  • PhD Pharmacology, Dalhousie University, 1982
  • BSc Biochemistry, Dalhousie University, 1977

Interests

General

  • Preclinical drug development in breast and prostate cancer therapy

Specific

  • Peripheral and central mechanisms of cancer-induced bone pain
  • Mechanisms of cancer-induced depression
  • Glutamatergic intercellular communication in bone metastasis
  • Mitochondrial stress signalling and oxidative stress

Selected Links


Team Members

Research Scientist

Dr. E. Seidlitz

Post-Doctoral Fellows

Drs. H. Lin, K. Linher-Melville

Research Assistants

N. Zacal, R. Ungard

Graduate Students

M. Balenko, J. Fazzari, E. Habib, M. Nashed

Selected Publications

  • Ungard RG, Seidlitz EP, Singh G. Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain. Pain 2014; 155: 28-36.
  • Sanli T, Steinberg GR, Singh G, Tsakiridis T. AMP-activated protein kinase (AMPK) beyond metabolism: A novel genomic stress sensor participating in the DNA damage response pathway. Cancer Biol Ther 2014; 15: 147-244.
  • Singh G. Mitochondrial FAD-linked Glycerol-3-phosphate Dehydrogenase: A Target for Cancer Therapeutics. Pharmaceuticals (Basel) 2014; 7: 192-206.
  • Verschoor ML, Verschoor CP, Singh G. Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers. Cancer Metab 2013; 1: 17.
  • Nashed MG, Balenko MD, Singh G. Cancer-induced oxidative stress and pain. Curr Pain Headache Rep 2014; 18: 384.
  • Verschoor ML, Singh G. Ets-1 regulates intracellular glutathione levels: key target for resistant ovarian cancer. Mol Cancer 2013; 12: 138.
  • Verschoor ML, Ungard R, Harbottle A, Jakupciak JP, Parr RL, Singh G. Mitochondria and cancer: past, present, and future. Biomed Research International 2013; 2013: 612369.
  • Ungard RG, Seidlitz EP, Singh G. Oxidative stress and cancer pain. Canadian Journal of Physiology and Pharmacology 2013; 91: 31-37.
  • Cowan RW, Singh G. Giant cell tumor of bone: a basic science perspective. Bone 2013; 52: 238-246.

Books Edited

  • Singh G, Rabbani S. Bone Metastasis: Experimental and Clinical Therapeutics. Totowa, N.J.: Humana Press Inc.; 2005.
  • Singh G, Orr FW. Bone Metastasis and Molecular Mechanisms. Dordrecht: Kluwer Academic Publishers; 2004.
  • Orr FW, Singh G. Bone Metastasis: Mechanisms and Pathophysiology. Norwell, MA: R.G. Landes/Chapman Hall; 1996.
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