McMaster University

McMaster University

Kenneth L. Rosenthal

, PhD

Pathology and Molecular Medicine

McMaster Immunology Research Centre
Head, Viral Vaccines Division

McMaster University
Institute for Molecular Medicine and Health
4019 Michael DeGroote Centre for Learning & Discovery
905-525-9140 ext. 22375
Lab: MDCL 4074 ext. 22494

Currently accepting Graduate Students
Currently accepting Post Doctoral Fellows

Kenneth L. Rosenthal

Faculty Biography

Education and Professional Standing

  • PhD, McMaster University, 1978
  • MSc, University of Illinios, 1974
  • BSc, University of Illinois, 1972


Research Focus

The Rosenthal laboratory is focused on:

  • Understanding the role of innate and adaptive mucosal immune responses in chronic viral infections, including HIV-1 and HSV-2
  • Understanding the role of innate mucosal immunity in resistance to sexually-transmitted viral infections and mother-to-child HIV transmission
  • Understand the mechanisms used by mucosally-transmitted viruses to evade, subvert and suppress host innate and adaptive immune responses to establish persistent infections
  • Development of mucosal vaccines, adjuvants and microbicides against mucosal viral infections

Despite the fact that the vast majority of viruses initiate infection at mucosal surfaces of the respiratory, digestive and genital tracts, we have a poor understanding of mucosal innate and adaptive immune responses against these viruses.  This is particularly true for HIV, which is a sexually-transmitted infection (STI) that rapidly targets the mucosal immune system for infection and destruction.  Furthermore, we lack the knowledge required to develop effective, long-lasting mucosal vaccines or microbicides to protect against mucosally- transmitted pathogens.

Our studies are being carried out in mouse models of virus infection or using specimens from cohorts of uninfected and infected humans in Canada or internationally. We have established model systems and techniques, including immunological, virological and molecular, to make significant observations concerning the triggering, maintenance, function and role of mucosal innate and adaptive immune responses following infection, treatment or immunization.  We also collaborate with investigators around the world to achieve our research goals.

Our work aims to contribute to our understanding of transmission, infection, control and prevention of relevant human pathogens, such as HIV and HSV-2.

Academic Interests

Dr. Rosenthal is involved in teaching within the Undergraduate Health Science, Arts and Science, Biology, Biochemistry, and Life Science Programs.  Furthermore, at the graduate level he teaches advanced immunology, virology, and pathology, with a special focus on viral disease and HIV/AIDS within the Medical Sciences Program.


Selected Publications

Visit Dr Rosenthal's McMaster Immunology Research Centre (MIRC) web profile for more information


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