Education and Professional Standing
- FRCPath: Fellow of Royal College of Pathologists, UK
- PDF, McMaster University, Canada
- PDF, University of Manchester, UK
- PhD, Akita University, Japan
- MBBS, Dhaka Medical College, University of Dhaka, Bangladesh
Main Research Areas
Mucosal immunology, Intestinal inflammation, Immuno-endocrine interaction and Host defence in the context of intestinal infection/inflammation.
Infection and inflammation in the gastrointestinal (GI) tract is associated with activation of immune system and alteration in the intestinal physiology which includes changes in neuro-endocrine function, mucin production and motility. Using models of enteric infection and inflammatory bowel disease (IBD) my research involves studies on interaction between immune and endocrine systems in relation to gut inflammation and host defense. I am investigating how the immune system controls endocrine system in gut particularly the function of enterochromaffin cells and serotonin production and the role of serotonin in immune activation, inflammation and host defense. I am also investigating the roles T cell subsets, cytokines, and chemokines in regulation of mucin producing intestinal goblet cells and intestinal muscle function in the context of GI infection/inflammation. In addition, my research also includes investigations on immunological strategies to modulate intestinal inflammation in experimental models of IBD.
Cell culture, immunohistochemistry, immuno-fluorescence, lymphocyte proliferation study, ELISA, multiplex immunoassay system, western blotting, flow-cytometry, laser capture micro-dissection, denaturing gradient gel electrophoresis and RT-PCR.
Dr Khan is involved in the Medical Sciences Graduate Program and teaches the following topics:
- Infection and Immunity
- Course coordinator:
- Graduate Course MS713: Integrated systems in gastrointestinal health and disease (1): Physiology and Pathophysiology of GI tract
- Graduate Course MS769: Integrated systems in gastrointestinal health and disease (2): Immunology, Inflammation & Microbiology of GI tract
Dr. Khan is also involved in training post-graduate medical biochemistry residents and fellows and general pathology residents, thesis supervision within the Undergraduate Bachelor of Health Science Program and Life Science Program, and is a Faculty of Health Sciences MD/PhD Program faculty member.
Technical Assistant: Huaqing Wang
Research Fellow: Emmanuel Denou
Graduate Students: Janice Kim, Sharif Shajib
Undergraduate Students: Adrian Bulfon, Yasmeen Mansoor
Administrative Assistant: Alyssa Abbott