Education and Professional Standing
- Ph.D. University of London (UK) 1972
- M.Sc. University of London (UK) 1967
- B.Sc. University of London (UK) 1964
- Retired from active research in 2006
Over recent years, my research was directed to comparing the dynamics of hemostasis in (a) an intravascular model of coagulation (the acutely-de-endothelialized aorta wall), and (b) in an extravascular model of coagulation (the procoagulant VX-2 lung tumor) in rabbits. For this purpose, interactions between individual radiolabelled rabbit blood proteins and/or radiolabelled rabbit platelets at the site of arterial injury, or within the VX-2 tumor stroma, were measured in vitro and in vivo. Using the VX-2 tumour model, the effusion of hemostasis proteins (and their metabolic products) from the tumour stroma to the interpleural space in vivo was also measured. In addition, observations of antiangiogenic components (angiostatin, D-dimer) in interpleural effusates were compared to similar components in ascites fluid samples obtained from ovarian cancer patients. Rabbit proteins (and their products of catabolism) of past interest included: fibrinogen; prothrombin (thrombin), antithrombin (α, β), heparin cofactor II; factors VII, IX, X, XIII; plasminogen (types I and II), α2-antiplasmin; fibronectin, vitronectin and von Willebrand factor. The ultimate objective was to construct and compare models of hemostasis that take place after arterial injury/healing, and during tumor growth in vivo.
I thank all who have worked with me during my research career in the department of Pathology at McMaster. Particular thanks go to Marnie DeReske Timleck, Dr. Mary Richardson, Bonnie Ross, Arlene Scopaz and Suzanne Southward. Without help from these and many other colleagues in the past, much of what I have done would not be conceivable let alone possible.