Laurie Doering

, PhD

Associate Professor
Pathology and Molecular Medicine

Division: Anatomy

Associate Member, McGill University

McMaster University
1R1A Health Sciences Centre
905-525-9140 ext. 22913
doering@mcmaster.ca

Assistant: Sharon Ralph

Education and Professional Standing

PhD, Anatomy, University of Saskatchewan, 1983
MSc, Anatomy, University of Saskatchewan, 1980
BSc, Anatomy & Microbiology, Queen's University, 1977

---

Interests

Research Focus

Stem Cells, Neural Transplantation and CNS Disorders.

The laboratory studies the cell biology of neural stem cells. We isolate stem cells from the mouse and rat brain and expand the cells in culture. The growth and differentiation of the stem cells are characterized before transplantation into animal models of Parkinson's and the Fragile-X syndrome. The stem cells are used as a means of potential cell therapy to replace missing proteins and restore function in specific pathways of the animal models. An additional line of work examines the role of a protein phosphatase in neural stem cell formation and neuronal growth.

Tissue culture, transplantation of stem cells into the CNS, immunocytochemistry, fluorescence, confocal microscopy and imaging.

Academic Interests

Dr. Doering is very involved in teaching within the Faculty of Health Sciences. Currently, his academic involvement includes:

Graduate Studies

• Medical Sciences Program
• Biochemistry and Biomedical Sciences Program

• Radiology and Surgery Residency Training

Undergraduate Studies:

• Education Program in Anatomy
• Undergraduate Medical Program, Medical Foundations 1,2,3 and 5
• Bachelor of Health Sciences Program

Furthermore, Dr. Doering is also involved within the Department of Health, Aging and Society.

---

Team Members

Graduate Students: Connie Cheng

Undergraduate Students: Shawn Segeren, Lynn Li, Shivesh Goberdhan

Selected Publications

• Pacey, LKK and Doering LC (2007). Developmental expression of FMRP in the astrocyte lineage: Implications for Fragile X Syndrome. Glia 55:1601-1609.
• Schaffer P, Gleave JA, Lemon JA, Reid LC, Pacey LKK, Farncombe TH, Boreham DR, Zubieta J, Babich JW, Doering LC and Valliant JF (2008).  Iso-structural fluorescent and radioactive probes for monitoring neural stem and progenitor cell transplants.  Nuclear Medicine and Biology 35:159-169.
• Jacobs S and Doering LC (2010).  Astrocytes prevent abnormal neuronal development in the Fragile X mouse. J Neuroscience 30:4508-4514.
• Jacobs S, Nathwani M and Doering LC (2010). Fragile X astrocytes induce developmental delays in dendrite maturation and synaptic protein expression. BMC Neuroscience 11:132+ Image Highlight (Highly accessed).
• Gleave JA, Farncombe TH, Saab C and Doering LC (2010). Correlative SPECT imaging with Altropane in the rat model of Parkinson’s. Nuclear Medicine and Biology (In press).