Anthony J. Coyle, PhD

Assistant Professor (Part-Time)
Pathology and Molecular Medicine

Senior Director, Respiratory and Autoimmune Disease
MedImmune, Inc.
1 MedImmune Way
Gaithersburg, MD, U.S.A.
301-398-4520
Coylea@medimmune.com

Education and Professional Standing

PhD, Pharmacology, University of London (England), 1989

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Interests

T cell costimulation and activation.

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Selected Publications

Coyle AJ, Gutierrez-Ramos JC. The role of ICOS and other costimulatory molecules in allergy and asthma. Springer Semin Immunopathol. 2004 Feb;25(3-4):349-59. Epub 2004 Jan 14.

Grant EP, Coyle AJ, Gutierrez-Ramos JC. Informatics and the immune system: the expanding IL-1 and B7 protein families. Semin Immunol. 2003 Aug;15(4):225-31.

Johnson JR, Wiley RE, Fattouh R, Swirski FK, Gajewska BU, Coyle AJ, Gutierrez-Ramos JC, Ellis R, Inman MD, Jordana M. Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling. Am J Respir Crit Care Med. 2004 Feb 1;169(3):378-85. Epub 2003 Nov 03.

Grant , E.P., Picarella, D., Burwell, T., Delaney, T., Croci, A., Avitahl, N., Humbles, A., Gutierrez-Ramos, J-C., Brikin, M., Gerard, C., Coyle, A.J.(2002) Essential role of C5a receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis. J, Exp Med., 196., 1461-71.

Gonzalo JA, Tian J, Delaney T, Corcoran J, Rottman JB, Lora J, Al-Garawi A, Kroczek R, Gutierrez-Ramos JC, Coyle AJ (2001). ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nat Immunol., 2., 597-604.

Coyle AJ, Lehar, S., Lloyd, CM, Delaney, T., Tian, J., Manning, S., Nguyen, T., Burwell, T., Scheider, H., Gonzalo, JA, Gosselin, M., Rudolph-Owen, L., Rudd, C.E., and Gutierrez-Ramos, JC (2000). The CD28 related molecule ICOS, is required for effective T cell dependent Immune responses. Immunity, 13, 95-105