Education and Professional Standing
PhD, Anatomy, University of Toronto, 1975
MSc, Microbiology, University of Manitoba, 1970
BSc, Agriculture, McGill University, 1967
Investigation of normal and abnormal coagulation in man and animals. Our principal focus is on initiation of coagulation via the extrinsic pathway, i.e. the interaction of plasma factor VII(FVII) and its cell surface receptor tissue factor (TF).
We are currently involved in three areas of research: (a) elucidation of the amino acid residues of human FVII which are directly involved in the binding to TF; (b) analysis of the role of the FVII-TF complex in disseminated intravascular coagulation in the rabbit; and (c) study of the effect of FVII and other coagulation proteins on the growth of tumours in the rabbit lung.
Our lab utilizes a variety of techniques to attempt to address fundamental questions in coagulation. These methods include cell culture, recombinant DNA techniques and immunological methods. We also have the capability to perform computer-assisted molecular modelling (in collaboration with Dr. Daniel Yang of the Biochemistry Department).