McMaster University

McMaster University
Faculty of Health Sciences
Department of Surgery

Hamilton NeuroRestorative Group

Stuart Phillips

Stuart Phillips

Dr. Stuart M. Phillips, Ph.D.
Professor, Kinesiology, Associate Member, Medicine (Cell Biology & Metabolism), IWC
Email: phillis@mcmaster.ca

Stuart Phillips graduated with an honours B.Sc. in biochemistry from McMaster University in 1989, obtained a M.Sc. in Human Nutritional Biochemistry in 1991, also from McMaster University. He then obtained a Ph.D. from the University of Waterloo in Human Physiology in 1995, where he received the University’s Outstanding Graduate Thesis Award. He went on to work in Dr. Robert Wolfe’s laboratory at the University of Texas Medical Branch in Galveston, Texas. Working with Dr. Wolfe he published the first data in humans that directly examined skeletal muscle protein breakdown without using catheterization. Returning to McMaster University in 1999 he accepted a position as an Assistant Professor in the Department of Kinesiology with a cross-appointment in Medicine. He was subsequently promoted to Associate Professor in 2003. He has received awards from the Canadian Society for Exercise Physiology, being awarded their Graduate Student award in 1996 and their Young Investigator Award in 2003.

His research is focused on the impact of nutrition and exercise on human protein turnover, specifically in skeletal muscle. He is also interested in how exercise impacts on the requirements for protein in humans. His research is funded by the Canadian Institutes for Health Research, the National Science and Engineering Council of Canada, the US National Dairy Council, the Dairy Farmer’s of Canada, and the Canadian Foundation for Innovation. Dr. Phillips is a New Investigator award recipient from the Canadian Institutes for Health Research and also a recipient of the Ontario Premier’s Research Excellence Award. An enthusiastic and energetic group of graduate students are the true heart of Dr. Phillips’ more than 120 publications and continuing enthusiasm for research.

Selected recent publications

  • K.R. Howarth, N.A. Moreau, S.M. Phillips, M.J. Gibala. Co-ingestion of protein with carbohydrate during recovery from endurance exercise stimulates skeletal muscle protein synthesis in humans.  J. Appl. Physiol. In press, 2009 - doi:10.1152/japplphysiol.90333.2008.
  • D.R. Moore, J.E. Tang, N.A. Burd, T. Rerecich, M.A. Tarnopolsky, and S.M. Phillips. Differential stimulation of myofibrillar and sarcoplasmic protein synthesis with protein ingestion at rest and after resistance exercise. J. Physiol. 587: 897-904, 2009.
  • D.R. Moore, M.J. Robinson, J.L. Fry, J.E. Tang, E.I. Glover, S.B. Wilkinson, T. Prior, M.A. Tarnopolsky and S.M. Phillips. Ingested protein dose-response of muscle and albumin protein synthesis after resistance exercise in young men. Am.J.Clin.Nutr. 89(1): 161-168, 2009.
  • C.E. O’Reilly, B.R. McKay, S.M. Phillips, M.A. Tarnopolsky, G. Parise. Hepatocyte growth factor (HGF) and the satellite cell response following muscle lengthening contractions in humans. Muscle Nerve, 38(5):1434-1442, 2008.
  • E.I. Glover, S.M. Phillips, B.R. Oates, J.E. Tang, M.A. Tarnopolsky, A. Selby,  K. Smith and M.J. Rennie. Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion. J. Physiol. 586:6049-6061, 2008
  • B.R. McKay, C.E. O'Reilly, S.M. Phillips, M.A. Tarnopolsky, and G. Parise. Co-expression of IGF-1 family members with myogenic regulatory factors following acute damaging muscle lengthening contractions in humans. J. Physiol. 586:5549-5560, 2008
  • E.I. Glover, B.R. Oates, J.E. Tang, D.R. Moore, M.A. Tarnopolsky, and S.M. Phillips. Resistance exercise decreases eIF2Be phosphorylation and potentiates the feeding-induced stimulation of p70S6k and rpS6 in young men. Am J Physiol Regul Integr Comp Physiol. 295(2):R604-610, 2008
  • J.E. Tang, J.G. Perco, D.R. Moore, S.B. Wilkinson, and S.M. Phillips. Resistance training alters the response of fed-state mixed muscle protein synthesis in young men . Am. J. Physiol. Regul. Integr. Comp. Physiol. 294(1):R172-178, 2008.
  • K.A. Burgomaster, K.R. Howarth, S.M. Phillips, M. Rakobowchuk, M.J. MacDonald, S.L. McGee, M.J. Gibala. Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J. Physiol. 586(1):151-160, 2008.
  • J.E. Tang, J.J. Manolakos, G.W. Kujbida, P.J. Lysecki, D.R. Moore, and S.M. Phillips. Minimal whey protein with carbohydrate stimulates muscle protein synthesis following resistance exercise in trained young men. Appl. Physiol. Nutr. Metab. 32(6): 1132-1138, 2007.
  • K.R. Howarth, K.A. Burgomater, S.M. Phillips, M.J. Gibala. Exercise training increases branched-chain oxoacid dehydrogenase kinase content in human skeletal muscle. 293(3):R1335-1341, 2007.
  • M.A. Tarnopolsky, S.M. Phillips, G. Parise, A. Varbanov, J. Demuth, P. Stevens, X.Y. Qu, F. Wang, and R. Isfort. Gene expression, fiber type, and strength are similar between legs in older adults. J. Gerontol. A. Biol. Sci. 62: 1088-1095, 2007.
  • J.W. Hartman, J.E. Tang, S.B. Wilkinson, M.A. Tarnopolsky, R.L. Lawrence, A.V. Fullerton, and S.M. Phillips. Consumption of fat-free fluid milk following resistance exercise promotes greater lean mass accretion than soy or carbohydrate consumption in young novice male weightlifters. Am. J. Clin, Nutr. 86(2): 373-381, 2007.
  • F. Poelkens, M. Rakobowchuk, K.A. Burgomaster, M.T.E. Hopman, S.M. Phillips, and M.J. MacDonald. Effect of unilateral resistance training on arterial compliance in elderly men. Appl. Physiol. Nutr. Metab. 32(4): 670-676, 2007.
  • K.A. Burgomaster, N.M. Cermak, S.M. Phillips, C.R. Benton, A. Bonen, and M.J. Gibala. Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292(5): R1970-R1976, 2007.
  • D.R. Moore, N.C. Del Bel, K.I. Nizi, J.W. Hartman, J.E. Tang, D. Armstrong, S.M. Phillips. Resistance training reduces fasted- and fed-state leucine turnover and increases dietary nitrogen retention in previously untrained young men. J. Nutr. 137(4):985-991,2007.
  • S.B. Wilkinson, M.A. Tarnopolsky, M.J. MacDonald, J.R. MacDonald, D. Armstrong and S.M. Phillips. Consumption of fluid skim milk promotes greater muscle protein accretion following resistance exercise than an isonitrogenous and isoenergetic soy protein beverage. Am. J. Clin. Nutr. 85(4):1031-1040, 2007.
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