My research investigates the mechanisms of allergic inflammation in human models of allergic asthma. Ongoing clinical studies examine the effects of experimental therapies on allergen-induced changes in airway physiology and inflammation, with emphasis on the activation of leukocytes known to participate in the allergic response.
More specifically, research conducted in my laboratory examines the activation of eosinophils, basophils, and their progenitors in samples from airways, blood and bone marrow. We have shown that airway epithelial cell-derived products such as TSLP are important inducers of airway inflammation, in part through the activation of basophils.
These experiments employ a variety of methodologies including:
- Pulmonary function testing
- Allergen provocation
- Sputum analysis
- Flow cytometry