McMaster University

Medical Sciences
Graduate Program

Scope of Search

Gail M. Gauvreau

Gail M. Gauvreau

BSc, MSc, PhD
Professor

Research Interests

My research investigates the mechanisms of allergic inflammation in human models of allergic asthma. Ongoing clinical studies examine the effects of experimental therapies on allergen-induced changes in airway physiology and inflammation, with emphasis on the activation of leukocytes known to participate in the allergic response.

More specifically, research conducted in my laboratory examines the activation of eosinophils, basophils, and their progenitors in samples from airways, blood and bone marrow. We have shown that airway epithelial cell-derived products such as TSLP are important inducers of airway inflammation, in part through the activation of basophils.


These experiments employ a variety of methodologies including:

  • Pulmonary function testing
  • Allergen provocation
  • Sputum analysis
  • Bronchoscopy
  • ELISA
  • Flow cytometry
  • Immunohistochemistry

Contact

McMaster University
Health Sciences Centre

telephone:(905) 525-9140 ext. 22791
email: gauvreau@mcmaster.ca
web: Dr. Gauvreau's Lab

Program Area

Physiology & Pharmacology

Research Focus

Allergic Asthma, Airway Physiology, Clinical Trials, Inflammation, Progenitor Cells, Molecular Biology

Selected Publications

  • Gauvreau GM, El-Gammal AI, O'Byrne PM. Allergen-induced airway responses. Eur Respir J. 2015 Sep;46(3):819-31.

  • Gauvreau GM, O'Byrne PM, Boulet L-P, Wang D, Cockcroft DW, Bigler J, Fitzgerald JM, Boedigheimer M, Davis BE, Dias C, Gorski K, Smith L, Bautista E, Comeau MR, Leigh R, Parnes JR. Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med. 2014 May 29;370(22):2102-10.

  • Gauvreau GM, Harris JM, Boulet LP, Scheerens H, Fitzgerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y, DahlĂ©n B, Wang Y, Maciuca R, Mayers I, Liao XC, Wu LC, Matthews JG, O'Byrne PM. Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production. Sci Transl Med. 2014 Jul 2;6(243):243ra85