Division of Respirology

Norman Jones


Professor Emeritus, Division of Respirology, Department of Medicine



Education and Professional Standing

Dr. Norman Jones came to McMaster in 1968 as the first Head of the Division of Respirology, having worked at the Royal Postgraduate Medical School in London with Dr E. J. Moran Campbell. He established the Regional Centre for Respiratory Medicine at St Joseph’s Hospital, and moved to McMaster Health Sciences Center in 1971 to be the Director of the Ambrose Cardiorespiratory Unit, a position he held until retirement in 1991. He is Professor Emeritus in the Department of Medicine.

His research dealt with many aspects of exercise. He established a comprehensive system of clinical exercise testing, and with Dr Kieran Killian showed the benefit of the routine measurement of symptom intensity. He was one of the first to support Peter Stewart’s approach to the assessment of acid-base homeostasis and applied it to intracellular changes by using the needle muscle biopsy technique of Hultman. With Dr George Heigenhauser he established the importance of pyruvate dehydrogenase activity on lactate production. The effectiveness of muscle strength training was demonstrated in the elderly and patients with coronary artery disease and chronic obstructive pulmonary disease.

He was honoured by the American College of Sports Medicine and the American College of Chest Physicians. He was inducted into the McMaster Health Sciences Community of Distinction in 2010.

Book Publications

  1. Jones NL, Clinical Exercise Testing. W.B. Saunders, 1st Edition, 1976, 2nd Edition, 1982, 3rd Edition, 1988. 4th Edition 1997.

Selected Publications

  1. Fletcher CM, Jones NL, Burrows B, Niden AH. American emphysema and British bronchitis: a standardised comparative study. Am Rev Respir Dis. 90 1-13, 1964.
  2. Jones NL. Pulmonary gas exchange during exercise in patients with chronic airway obstruction.Clin Sci 31 39-50, 1966.
  3. McHardy GJR, Jones NL, Campbell EJM. Graphical analysis of CO2 transport. Clin Sci 32 289-298, 1967.
  4. Havel RJ, Pernow B, Jones NL. Uptake and release of free fatty acids and other metabolites in the legs of exercising men.J Appl Physiol. 23 90-96, 1967
  5. Hughes RL, Clode M, Edwards RHT, Goodwin TJ, Jones NL. Effect of inspired 02 on cardiopulmonary and metabolic responses to exercise in man.J Appl Physiol. 24 336 347, 1968.
  6. Jones NL, Jones G, Edwards RHT. Exercise tolerance in chronic airway obstruction. Am Rev Resp Dis 103 477-491, 1971.
  7. Jones NL. Exercise testing in pulmonary evaluation: rationale, methods and the normal respiratory response to exercise. New Eng J Med. 293 541 544, 1975.
  8. Jones NL, Sutton JR, Taylor R, Toews CJ. Effect of pH on cardiorespiratory and metabolic responses to exercise. J Appl Physiol. 43 959 964, 1977.
  9. Patterson DH, Shephard RJ, Cunningham D, Jones NL, Andrew G. Effects of physical training on cardiovascular function following myocardial infarction. J Appl Physiol: Respirat Environ Ex Physiol 47 482-489, 1979.
  10. Ward GR, Sutton JR, Jones NL, Toews CJ. Activation by exercise of human muscle pyruvate dehydrogenase in vivo. Clin Sci 63-87 92, 1982.
  11. McCartney N, Heigenhauser GJF, Jones NL. Effects of pH on maximal power output and fatigue during short term dynamic exercise. J Appl Physiol: Respirat Environ Ex Physiol. 55 225 229, 1983.
  12. Heigenhauser GJF, Sutton JR, Jones NL. Effect of glycogen depletion on the ventilatory response to exercise. J Appl Physiol: Respirat Environ Ex Physiol. 54 470-474, 1983.
  13. Jones GL, Killian KJ, Summers E, Jones NL.  Inspiratory muscle forces and endurance in maximum resistive loading. J Appl Physiol. 58 1608-1615, 1985.
  14. Guyatt GH, Pugsley SO, Sullivan MJ, Thompson PJ, Berman LB, Jones NL, Fallen E, Taylor DW. The six minute walk: A new test for measuring functional capacity in patients with chronic heart failure. Can Med Assoc. J. 132 919-923, 1985.
  15. Spriet LL, Lindinger MI, Heigenhauser, GJF, Jones NL. Effects of alkalosis on skeletal muscle metabolism and performance during exercise. Am J Physiol. 251 R833-R839, 1986.
  16. Leblanc P, Summers E, Inman MD, Jones NL, Campbell EJM and Killian KJ. Inspiratory muscles during exercise: a problem of supply and demand. J Appl Physiol. 64 2482-2489, 1988.
  17. Kowalchuk JM, Heigenhauser, GJF, Lindinger M, Obminski G, Suttone J, Jones NL. The role of the lungs and inactive muscle in the control of H+ concentration after maximal exercise. J Appl Physiol. 65 2090-2096, 1988.
  18. Spriet LL, Lindinger MI, McKelvie RS, Heigenhauser GJF, Jones NL. Muscle glycogenolysis and hydrogen ion concentration during maximal intermittent cycling. J Appl Physiol. 66 8-13, 1989.
  19. Makrides L, Heigenhauser, GJF, Jones NL. High intensity endurance training in 20-30 and 60-70 year-old healthy men. J Appl Physiol. 69: 1792-1798, 1990.
  20. McKelvie RS, Lindinger MI, Jones NL, Heigenhauser GJF. Erythrocyte ion regulation across inactive muscle during leg exercise. Can J Physiol Pharmacol 1992; 70: 1625-1633.
  21. Simpson K, Killian K, McCartney N, Stubbing DG, Jones NL. Randomised controlled trial of weightlifting exercise in patients with chronic airflow limitation. Thorax, 47; 70-75, 1992.
  22. Putman CT, Spriet LL, Hultman E, Lindinger MI, Lands LC, McKelvie RS, Cederblad G, Jones NL, Heigenhauser GJF. Pyruvate dehydrogenase activity and acetyl group accumulation during exercise after different diets. Am J Physiol 265: E752-E760, 1993.
  23. Killian KJ, Leblanc P, Martin DH, Summers E, Jones NL, Campbell EJM. Exercise capacity, ventilatory, circulatory, and symptom limitation in patients with chronic airflow limitation. Am Rev Respir Dis, 146: 935-940, 1992.
  24. Jones NL, Christie, Meakins and exercise limitation in chronic airflow obstruction. Can Resp J 4: 227-234, 1996.
  25. Parolin ML, Spriet LL, Hultman E, Hollidge Horvat MG, Jones NL, Heigenhauser GJ. Regulation of glycogen phosphorylase and PDH during exercise in human skeletal muscle during hypoxia. Am J Physiol Endocrinol Metab. 2000 Mar;278(3):E522 34.
  26. Jones NL. An obsession with CO2. Appl Physiol Nutr Metab, 2008, 33: 641-650.
  27. Jones NL. The Ins and Outs of Breathing. How we learnt about the body's most vital function. Bloomington, IN. iUniverse.com, 2011.