Department of Medicine
Featured Publications
| Month | Author | Journal | Title |
| February 2012 |
Drs. J. Healey, S. Connolly, C. Morillo et al | The New England Journal of Medicine | Subclinical Atrial Fibrillation and the Risk of Stroke. New England Journal of Medicine. 2012 Jan 12;366(2):120-9. > PubMed Reference |
| January 2012 |
Dr. G. Steinberg et al | The Journal of Clinical Investigation | Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. The Journal of Clinical Investigation. 2011 Dec 1;121(12):4903-15. doi: 10.1172/JCI58577. Epub 2011 Nov 14 > PubMed Reference |
| December 2011 |
Dr. S. Schulman et al | Annals of Internal Medicine | Warfarin Dose Assessment Every 4 Weeks Versus Every 12 Weeks in Patients
With Stable International Normalized Ratios. Annals of Internal Medicine 2011 Nov 15;155(10):653-9 > PubMed Reference |
| November 2011 |
Drs. S. Yusuf, C. Chow and K. Teo et al | The Lancet | Use of secondary prevention drugs for cardiovascular disease in the community in high-income,
middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey.
Lancet. 2011 Oct 1;378(9798):1231-43. Epub 2011 Aug 26. > PubMed Reference |
| October 2011 |
Drs. M. Tarnopolsky and G. Steinberg et al | Proceedings of the National Academy of Sciences of the USA |
AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role
for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci U S A.
2011 Sep 20;108(38):16092-7. Epub 2011 Sep 6. > PubMed Reference |
| September 2011 |
Drs. P Imbach and M Crowther | The New England Journal of Medicine | Thrombopoietin-Receptor Agonists for Primary Immune Thrombocytopenia. N Engl J Med 2011; 365:734-41. > PubMed Reference |
| August 2011 |
Drs. Schertzer, Fullerton and Steinberg et al | Diabetes |
NOD1 Activators Link Innate Immunity to Insulin Resistance. Diabetes. 2011 Jun 29. [Epub ahead of print]. > PubMed Reference |
| July 2011 |
Drs. Devereaux, Gordon Guyatt, Salim Yusuf et al | Annals of Internal Medicine |
Characteristics and short-term prognosis of perioperative myocardial infarction in patients undergoing noncardiac surgery: a cohort study. Ann Intern Med. 2011 Apr 19;154(8):523-8. > PubMed Reference |
| June 2011 |
Drs. D. Cook, M. Meade, G. Guyatt, M. Crowther et al | The New England Journal of Medicine |
Dalteparin versus unfractionated heparin in critically ill patients. N Engl J Med. 2011 Apr 7;364(14):1305-14. Epub 2011 Mar 22. > PubMed Reference |
| May 2011 |
Dr. HC Gerstein et al | The New England Journal of Medicine |
Long-term effects of intensive glucose lowering on cardiovascular outcomes. N Engl J Med. 2011 Mar 3;364(9):818-28. > PubMed Reference |
| April 2011 |
Dr. SJ Connolly, J Eikelboom, M O'Donnell and S Yusuf et al | The New England Journal of Medicine |
Apixaban in patients with atrial fibrillation. N Engl J Med. 2011 Mar 3;364(9):806-17. Epub 2011 Feb 10. > PubMed Reference |
| March 2011 |
Dr. Mark Loeb et al | Journal of American Medical Association |
Effect of influenza vaccination of children on infection rates in Hutterite communities: a randomized trial. JAMA. 2010 Mar 10;303(10):943-50. > PubMed Reference |
| February 2011 |
Drs. A Iorio and C Kearon et al | Archives of Internal Medicine |
Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor: a systematic review. Arch Intern Med. 2010 Oct 25;170(19):1710-6. > PubMed Reference |
| January 2011 |
Dr. M Dolovich et al | The Lancet |
Aerosol drug delivery: developments in device design and clinical use. Lancet. 2010 Oct 29. [Epub ahead of print] > PubMed Reference |
| December 2010 |
Drs. G Paré, S Mehta, S Yusuf, S Anand, S Connolly, J Hirsh and J Eikelboom et al | The New England Journal of Medicine |
Effects of CYP2C19 genotype on outcomes of clopidogrel treatment. N Engl J Med. 2010 Oct 28;363(18):1704-14. > PubMed Reference |
| November 2010 |
Drs. J Douketis, A Iorio et al | Annals of Internal Medicine |
Patient-level meta-analysis: effect of measurement timing, threshold, and patient age on ability of D-dimer testing to assess recurrence risk after unprovoked venous thromboembolism. Ann Intern Med. 2010 Oct 19;153(8):523-31. > PubMed Reference |
| October 2010 |
Drs. SR Mehta, JW Eikelboom, SS Jolly, S Yusuf et al | The Lancet |
Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. Lancet. 2010 Sep 1. [Epub ahead of print] > PubMed Reference |
| September 2010 | Dr. H. Gerstein et al | The New England Journal of Medicine | Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med. 2010 Jul 15;363(3):233-44. Epub 2010 Jun 29. > PubMed Reference |
| August 2010 |
Drs. MJ O'Donnell, S. Yusuf et al | The Lancet |
Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet. 2010 Jul 10;376(9735):112-23. Epub 2010 Jun 17. > PubMed Reference |
| July 2010 |
Dr. JL Wallace et al | Proceedings of the National Academy of Sciences of the USA |
A pro-resolution mediator, prostaglandin D2, is specifically up-regulated in individuals in long-term remission from ulcerative colitis. Proc Natl Acad Sci USA. 2010 Jun 14.[Epub ahead of print] > PubMed Reference |
| June 2010 |
Drs. M. Crowther, S. Mehta, J. Eikelboom et al | Circulation | Triple antithrombotic therapy in patients with atrial fibrillation and coronary artery stents. Circulation. 2010 May 11;121(18):2067-70. > PubMed Reference |
| May 2010 |
Dr H. Gerstein and ACCORD Study Group | New England Journal of Medicine | Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus. N Engl J Med. 2010 Apr 29;362(17):1563-74. > PubMed Reference |
| April 2010 |
Drs. D. Hunt and A. Panju et al | Journal of American Medical Association | Does This Patient With Diabetes Have Large-Fiber Peripheral Neuropathy? JAMA. 2010;303(15):1526-1532. > Article pdf |
| March 2010 |
Drs. J. Anderson, J. Hirsh, S. Yusuf, R. Afzal, S. Mehta and J. Eikelboom et al | Journal of Thrombosis and Hemostasis | Comparison of the anticoagulant intensities of fondaparinux and enoxaparin in the organization to assess strategies in acute ischemic syndromes (OASIS)-5 trial. J Thromb Haemost. 2010 Feb;8(2):243-9. > PubMed reference |
| February 2010 |
Dr. Mark Loeb et al | American Journal of Respiratory and Critical Care Medicine | Long-term exposure to ambient air pollution and risk of hospitalization with community-acquired pneumonia in older adults. Am J Respir Crit Care Med. 2010 Jan 1;181(1):47-53. Epub 2009 Oct 1. > PubMed reference |
| January 2010 |
Drs. Sam Schulman, Clive Kearon et al | The New England Journal of Medicine | Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism. N Engl J Med. 2009 Dec 10;361(24):2342-2352. > PubMed reference |
| December 2009 |
Dr. Sam Schulman et al | The Journal of Thrombosis and Haemostasis | The absence of 'minor' risk factors for recurrent venous thromboembolism: a systematic review of negative predictive values and negative likelihood ratios. J Thromb Haemost. 2009 Oct;7(10):1619-28. Epub 2009 Jul 17. > PubMed reference |
| November 2009 |
Drs. Alexandra Papaioannou, Jonathan D. (Rick) Adachi et al | The Canadian Medical Association Journal | Relation between fractures and mortality: results from the Canadian Multicentre
Osteoporosis Study. CMAJ. 2009 Sep 1;181(5):265-71. Epub 2009 Aug 4. > PubMed reference |
| October 2009 |
Drs. Stuart Connolly, Salim Yusuf, John Eikelboom et al | The New England Journal of Medicine | Dabigatran versus warfarin in patients
with atrial fibrillation. N Engl J Med. 2009 Sep 17;361(12):1139-51.
Epub 2009 Aug 30. > PubMed reference |
| September 2009 |
Dr. Susan Waserman et al | The Journal of Allergy and Clinical Immunology | Concurrent blockade of platelet-activating
factor and histamine prevents life-threatening peanut-induced anaphylactic
reactions. J Allergy Clin Immunol. 2009 Aug;124(2):307-14, 314.e1-2. Epub 2009 May 5. > PubMed reference |
| August 2009 |
Dr. Peter Margetts, Dr. Mark Inman, Dr. Martin Kolb et al | The Journal of Clinical Investigation | VEGF ameliorates pulmonary hypertension
through inhibition of endothelial apoptosis in experimental lung
fibrosis in rats. J Clin Invest. 2009 May;119(5):1298-311. > PubMed reference |
| July 2009 |
Dr. Madhu Natarajan, Dr. Salim Yusuf et al | New England Journal of Medicine | Early versus delayed invasive intervention
in acute coronary syndromes. N Engl J Med. 2009 May 14;360(20):2066-78.
Epub 2009 Mar 31. > PubMed reference |
| June 2009 |
ACTIVE Investigators: Connolly SJ, Pogue J, Hart RG, Hohnloser SH, Pfeffer M, Chrolavicius S, Yusuf S | New England Journal of Medicine | Effect of Clopidogrel Added to Aspirin
in Patients with Atrial Fibrillation N Engl J Med. 2009 May 14;360(20):2066-78.
Epub 2009 Mar 31. |
| May 2009 |
Dr. Paul Moayyedi et al | Archives of Internal Medicine | Yield of Diagnostic Tests for Celiac
Disease in Individuals With Symptoms Suggestive of Irritable Bowel
Syndrome: Systematic Review and Meta-analysis. Arch Intern Med. 2009
Apr 13;169(7):651-8. |
| April 2009 |
Drs. Gerard Cox, Deborah Cook, Peter Margetts, Paul O’Byrne, Martin Kolb et al | The American Journal of Respirology and Critical Care Medicine | Circulating Fibrocytes Are an Indicator
of Poor Prognosis in Idiopathic Pulmonary Fibrosis. Apr 1;179(7):588-94.
Epub 2009 Jan 16. |
| March 2009 |
Drs. Parameswaran Nair, Mark Inman, Frederick Hargreave, Paul O’Byrne et al | New England Journal of Medicine | Mepolizumab for Prednisone-Dependent
Asthma with Sputum Eosinophilia, NEJM. 2009 Mar 5; 360(10):985-993 |
| February 2009 |
Drs. Sanjit Jolly and Salim Yusuf et al | American Heart Journal | Radial Versus Femoral Access for
Coronary Angiography or Intervention and the Impact on Major Bleeding
and Ischemic Events: A Systematic Review and Meta-Analysis of Randomized
Trials, Am Heart J. 2009 Jan;157(1):132-40 |
| January 2009 |
Dr. Brian Leber et al | Cell | Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax, Cell 2008 Dec 12; 135(6):1074-84 |
| December 2008 |
Drs. Roman Jaeschke, Parameswaran Nair, Malcolm Sears, Paul O’Byrne, Gordon Guyatt et al | The American Journal of Respiratory and Critical Care Medicine | The Safety of Long-Acting β-Agonists among Patients with Asthma Using Inhaled Corticosteroids, Am J Respir Crit Care Med 2008; 178:1009-1016. > PubMed reference |
| November 2008 |
Dr. Salim Yusuf et al | New England Journal of Medicine | Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events, N Engl J Med 2008 Sep 18; 359(12):1225-37. |
| October 2008 |
Dr. Patricia Liaw et al | The Journal of Immunology | Activated Protein C Up-Regulates IL-10 and Inhibits Tissue Factor in Blood Monocytes, J Immunol 2008 Aug 1; 181(3): 2165-73. |
| September 2008 |
Drs. Frederick Spencer and Jeff Ginsberg et al | The Journal of Thrombosis and Haemostasis | The Relationship Between Unprovoked Venous Thromboembolism, Age and Acute Myocardial Infarction, J Thromb Haemost 2008; 6: 1507-13. |
| August 2008 |
Drs. P J Devereaux, Salim Yusuf, Gordon Guyatt and the POISE Study Group | The Lancet | Effects of Extended-Release Metoprolol Succinate in Patients Undergoing Non-Cardiac Surgery (POISE Trial): A Randomised Controlled Trial, Lancet 2008 May 31;371(9627):1839-47. |
| July 2008 |
Dr. Hertzel Gerstein and the ACCORD Study Group | New England Journal of Medicine | Effects of Intensive Glucose Lowering in Type 2 Diabetes, N Engl J Med 2008;358:2545-59 |
| June 2008 |
Dr. Stephen Collins et al | Journal of Clinical Investigation | Impaired Parasympathetic Function Increases Susceptibility to Inflammatory Bowel Disease in a Mouse Model of Depression, J. Clin. Invest. doi:10.1172/JCI32849 |
| May 2008 |
Dr. Salim Yusuf and Dr. Koon Teo et al |
New England Journal of Medicine | Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events, 2008; 358:1547-59. |
| April 2008 |
Dr. Frederick Spencer and Dr. James Douketis et al | Archives of Internal Medicine | Patient Outcomes after Deep Vein Thrombosis and Pulmonary Embolism, 2008; 168(4):425-430. |
| March 2008 |
Dr. Maureen Meade, Dr. Deborah Cook and Dr. Gordon Guyatt et al |
Journal of the American Medical Association |
Ventilation Strategy Using Low Tidal Volumes, Recruitment Maneuvers, and High Positive End-Expiratory Pressure for Acute Lung Injury and Acute Respiratory Distress Syndrome. February, 2008;
299(6):637-645 |
| February 2008 |
Dr. Petra Arck et al | Nature Medicine | A pivotal role for galectin-1 in fetomaternal tolerance. 2007 Dec;13(12):1450-7. |
| January 2008 |
Dr. James Douketis et al | Annals of Internal Medicine | The Risk for Fatal Pulmonary Embolism after Discontinuing Anticoagulant Therapy for Venous Thromboembolism. 2007;147:766-74. |
| December 2007 |
Dr. Jonathan (Rick) Adachi et al | New England Journal of Medicine | Zoledronic Acid and Clinical Fractures and Mortality after Hip Fracture. 2007;357:1799-809. |
| November 2007 |
Dr. Stuart Connolly et al | New England Journal of Medicine | Dronedarone for Maintenance of Sinus Rhythm in Atrial Fibrillation or Flutter. 2007;357:987-99. |
| October 2007 |
Drs. Sonia Anand | New England Journal of Medicine | Oral Anticoagulant and Antiplatelet Therapy and Peripheral Arterial Disease. 357:217-27, 2007. |
| September 2007 | Drs. Paul O’Byrne and Mark Inman et al | Nature Medicine | A GABAergic system in airway epithelium is essential for mucus overproduction in asthma. 13(7):862-7, 2007. |
| August 2007 | Dr. Annette Reboli | New England Journal of Medicine | Anidulafungin versus Fluconazole for Invasive Candidiasis. 356:2472-82, 2007. |
| July 2007 | Dr. Azim Gangji et al | Diabetes Care | A Systematic Review and Meta-Analysis of Hypoglycemia and Cardiovascular Events. A comparison of glyburide with other secretagogues and with insulin. 30:389-94, 2007. |
| June 2007 | Dr. William Boden et al | New England Journal of Medicine | Optimal Medical Therapy with or without PCI for Stable Coronary Disease. 2007;356(15):1503-16. |
| May 2007 | Dr. Gerard Cox et al | New England Journal of Medicine | Asthma Control During the Year After Bronchial Thermoplasty. 2007;356(13):1327-37. |
| Apr. 2007 | Dr. Theodore Warkentin et al | New England Journal of Medicine | Drug-Induced Immune-Mediated Thrombocytopenia – from Purpura to Thrombosis. 2007 Mar:356(9):891-3. |
| Mar. 2007 | Dr. MyLinh Duong et al | Journal of Allergy and Clinical Immunology | The effects of inhaled budesonide and formoterol in combination and alone when given directly after allergen challenge. 2007 Feb:119(2):322-7. |
| Feb. 2007 | Dr. Deborah Cook, Dr. Maureen Meade, Dr. Cindy Hamielec and the Canadian Critical Care Trials Group | New England Journal of Medicine | A Randomized Trial of Diagnostic Techniques for Ventilator-Associated Pneumonia. 2006; 355:2619-30. |
| Jan. 2007 | Dr. Wendy Lim et al | Archives of Internal Medicine | Elevated Cardiac Troponin Measurements in Critically Ill Patients. 2006;166(22):2446-54. |
| Dec. 2006 | Dr. Clive Kearon et al | Journal of the American Medical Association | Comparison of Fixed-Dose Weight-Adjusted Unfractionated Heparin and Low-Molecular-Weight Heparin for Acute Treatment of Venous Thromboembolism. 2006;296(8):935-42. |
| Nov. 2006 | Drs. Salim Yusuf, Hertzel Gerstein, DREAM Trial Investigators | New England Journal of Medicine | Effect of Ramipril on the Incidence of Diabetes. N Engl J Med 2006;355:1551-62. |
| Oct. 2006 | Dr. Koon Teo et al | The Lancet | Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study. The Lancet August 19, 2006;368:647-58. |
| Sept. 2006 | Dr. Irwin Walker et al | Blood | Mortality rates and causes of death among all HIV-positive individuals with hemophilia in Canada over 21 years of follow-up. Blood 15 July 2006; 108(2):460-464. |
| August 2006 | Dr. Paul Moayyedi et al | The Lancet | Gastro-oesophageal reflux disease. The Lancet 2006; 367:2086-100. |
| July 2006 | Dr. Mark Levine et al |
New England Journal of Medicine | HER2 and Responsiveness of Breast Cancer to Adjuvant Chemotherapy. The New England Journal of Medicine. 2006 May 18;354(20):2103-11. |
| June 2006 | Dr. Salim Yusuf and the OASIS-5 Investigators | New England Journal of Medicine | Comparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes. The New England Journal of Medicine. 2006 Apr 6(14);354:1464-76. > PubMed reference |
| May 2006 | Dr. Eva Lonn et al | New England Journal of Medicine | Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease. The New England Journal of Medicine. 2006 Mar 12; (Epub ahead of print) > PubMed reference |
| Apr. 2006 | Dr. Geoff Werstuck et al | Diabetes | Glucosamine-Induced Endoplasmic Reticulum Dysfunction Is Associated With Accelerated Atherosclerosis in a Hyperglycemic Mouse Model. > PubMed reference |
| Mar. 2006 | Dr. John Eikelboom et al | Circulation, The Journal of the American Heart Association | Unfractionated and Low-Molecular-Weight Heparin as Adjuncts to Thrombolysis in Aspirin-Treated Patients With ST-Elevation Acute Myocardial Infarction: A Meta-Analysis of the Randomized Trials > PubMed reference |
| Feb. 2006 | Dr. Deborah Cook et al | Journal of Critical Care | On the Need for a Workshop on Venous Thromboembolism in Critical Care (Editorial). J Crit Care 2005 Dec;20(4):306-8. |
| Jan. 2006 | Dr. Salim Yusuf et al | The Lancet | Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study > PubMed reference |
| Dec. 2005 | Dr. Catherine Demers et al | The Journal of the American Medical Association | Impact of candesartan on nonfatal myocardial infarction and cardiovascular death in patients with heart failure. > PubMed reference |
| Oct. 2005 | Dr. Malcolm Sears et al | American Journal of Respiratory and Critical Care Medicine | Sex differences in factors associated with childhood-and- adolescent-onset wheeze . > PubMed reference |
| Sept. 2005 | Dr. Ralph Meyer | Journal of Clinical Oncology | Randomized comparison of ABVD chemotherapy with a strategy that includes radiation therapy in patients with limited-stage Hodgkin's lymphoma: National Cancer Institute of Canada Clinical Trials Group and the Eastern Cooperative Oncology Group > PubMed reference |
