Division of Nephrology

Alistair Ingram


Professor, Division of Nephrology, Department of Medicine




Education and Professional Standing

  • Internal Medicine (UWO) 1990-1993
  • Nephrology (McMaster) 1993-1995
  • Research (U or T) 1995-1996

Research Interests

  • Prevention of vascular and thrombotic complications in chronic renal insufficiency and dialysis
  • Molecular biology of progressive renal diseases

Selected Publications

  1. Fung MA, Churchill DN, Alexopoulou IA, Ingram AJ. IgA Nephropathy and Pulmonary Hemorrhage in Adults. Am J Nephrol 2001; 21: 318-322
  2. James LR, Ingram AJ, Ly H, Thai K, Cai L, Scholey JW. Angiotensin II Activates the GFAT Promoter in Mesangial Cells. Am J Physiol (Renal) 2001; 281(1): F151-162
  3. Tang D, Okada H, Ruland J, Liu L, Stambolic V, Mak TW, Ingram AJ. Akt is Activated in Response to an Apoptotic Signal. J Biol Chem 2001; 276: 30461-30466
  4. James LR, Tang D, Ingram AJ, Ly H, Thai K, Cai L, Scholey JW. Flux Through the Hexosamine Pathway is a Determinant of NF-KB Dependent Promoter Activation. Diabetes 2002; 51: 1146-1156
  5. Brimble S, Rabbat CG, Schiff D, Ingram AJ. The Clinical Utility of Doppler Ultrasound Prior to AV Fistula Creation. Semin Dial 2001; 14: 314-317
  6. Krepinsky JC, Ingram AJ, James LR, Ly H, Thai K, Cattran DC, Miller JA, Scholey JW. 17B-Estradiol Modulates Mechanical Strain-Induced MAPK Activation in Mesangial Cells. J Biol Chem 2002; 277: 9387-9394
  7. Tang D, Hirao A, Lahti JM, Liu L, Wu D, Kidd VJ, Mak TW, Ingram AJ. Erk Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53. J Biol Chem 2002; 277: 12710-12717
  8. Wu D, Ingram AJ, Mazza B, Grenet J, Kapoor A, Liu L, Lahti JH, Kidd VJ, Tang D. Apoptotic Release of Histones from Nucleosomes. J Biol Chem 2002; 277: 12001-12008
  9. Crowther MA, Clase CM, Margetts PJ, Julian J, Lambert K, Sneath D, Nagai R, Wilson S, Ingram AJ. Low-Intensity Warfarin is Ineffective for the Prevention of PTFE Graft Failure in Patients on Hemodialysis- An RCT. J Am Soc Nephrol 2002; 13: 2331-2337
  10. Brimble KS, Rabbat CG, Treleaven DJ, Ingram AJ. Utility of Ultrasonographic Venous Assessment Prior to Forearm AVF Creation. Clin Nephrol 2002; 58: 122-127
  11. Krepinsky JC, Ingram AJ, Tang D, Wu D, Liu L, Scholey JW. NO Inhibits Stretch-Induced MAPK Activation in Mesangial Cells Through RhoA Inactivation. J Am Soc Nephrol 2003; 14: 2790-2800
  12. Ingram AJ et al. Activation of Mesangial Cell MAPK in Response to Homocysteine. Kidney Int 2004; 66: 733-745
  13. Li Y, Wu D, Chen B, Ingram AJ, He L, Liu L, Zhu D, Kapoor A, Tang D. ATM Activity Contributes to the Tumor-Suppressing Functions of P14ARF. Oncogene (in press 2004)
  14. Krepinsky JC, Li Y, Tang D, Liu L, Scholey JW, Ingram AJ. Stretch-Induced Raf-1 Activation in Mesangial Cells Requires Actin Cytoskeletal Integrity. Cellular Signaling (in press 2004)
  15. Krepinsky JC, Li Y, Peng FF, Tang D, Wu D, Chang Y, Liu L, Scholey JW, Ingram AJ. Akt Mediates Mechanical Strain-Induced Collagen Production by Mesangial Cells. J Biol Chem (submitted 2004)