Dr. Alistair Ingram

Division of Nephrology

Alistair Ingram

MD, FRCPC

Professor, Division of Nephrology, Department of Medicine

 

 

 

Education and Professional Standing

  • Internal Medicine (UWO) 1990-1993
  • Nephrology (McMaster) 1993-1995
  • Research (U or T) 1995-1996

Research Interests

  • Prevention of vascular and thrombotic complications in chronic renal insufficiency and dialysis
  • Molecular biology of progressive renal diseases

Selected Publications

  1. Peng F, Zhang B, Ingram AJ, Gao B, Zhang Y, Krepinsky JC. Mechanical Stretch-Induced RhoA Activation is Mediated by the RhoGEF Vav2 in Mesangial Cells. Cell Signal. 2010 Jan; 22(1):34-40.
  2. He L, Ingram AJ, Rybak AP, Tang D. Shank-interacting protein-like 1 (SIPL1) reduces PTEN function during tumorigenesis. J Clin Invest 2010; 120(6):2094-108.
  3. Zhang Y, Peng F, Gao B, Ingram AJ, Krepinsky JC.Mechanical strain-induced. RhoA activation requires NADPH oxidase-mediated ROS generation in caveolae. Antioxid Redox Signal. 2010 Oct 1;13(7):959-73.
  4. Dickhout JG, Lhoták Š, Hilditch BA, Basseri S, Colgan SM, Lynn EG, Carlisle RE, Zhou J, Sood SK, Ingram AJ, Austin RC. Induction of the unfolded protein response after monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions. FASEB J. 2011 Feb;25(2):576-89.
  5. Uttarwar L, Peng F, Wu D, Kumar S, Gao B, Ingram AJ, Krepinsky JC. HB-EGF Release Mediates Glucose-Induced Activation of the Epidermal Growth Factor Receptor in Mesangial Cells. Am J Physiol Renal Physiol. 2011 Feb 2.
  6. He L, Fan C, Kapoor A, Ingram AJ, Rybak AP, Austin RC, Dickhout J, Cutz JC, Scholey JW, and Tang D. Alpha-mannosidase 2C1 attenuates PTEN function during prostate tumorigenesis. Nature Communications 2011; 2: 307-311.
  7. Wilkieson TJ, Ingram AJ, Crowther MA, Soroka SD, Nagai R, Jindal KK, Clase CM Low-Intensity Adjusted-Dose Warfarin for the Prevention of Hemodialysis Catheter Failure: A Randomized, Controlled Trial. Clin J Am Soc Nephrol 2011 6(5):1018-24.
  8. Zhang Y, Peng F, Gao B, Ingram AJ, Krepinsky JC. High glucose-induced RhoA activation requires caveolae and PKCβ1-mediated ROS generation. Am J Physiol Renal Physiol. 2012 Jan;302(1):F159-72.
  9. Uttarwar L, Gao B, Ingram AJ, Krepinsky JC. SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells. Am J Physiol Renal Physiol. 2012 Feb;302(3):F329-41.
  10. Lhotak S, Sood S, Brimble E, Carlisle RE, Colgan SM, Mazzetti A, Dickhout JG, Ingram AJ, Austin RC ER Stress Contributes to Renal Proximal Tubule Injury Increasing SREBP-2-Mediated Lipid Accumulation and Apoptotic Cell Death.  Am J Physiol Renal Physiol. 2012 May 9
  11. MicroRNA-145 targeted therapy reduces atherosclerosis. Fina Lovren, Yi Pan, Adrian  Quan, Krishna K Singh, Praphulla C Shukla, Nandini Gupta, Brent M. Steer, Ingram AJ, Milan Gupta, Mohammed Al-Omran, Hwee Teoh, Philip A. Marsden, Subodh Verma. Circulation 2012
  12. BRCA1 is a novel target to improve endothelial dysfunction and retard  atherosclerosis. Singh KK, Shukla PC, Quan A, Al-Omran M, Lovren F, Pan Y, Brezden-Masley C, Ingram AJ, Stanford WL, Teoh H, Verma S.J Thorac Cardiovasc Surg. 2013 Feb 14.
  13. Anticoagulants in patients with atrial fibrillation and end-stage renal disease. Brimble KS, Ingram AJ, Eikelboom JW, Hart RG.Postgrad Med. 2012 Nov;124(6):17-25.
  14. Anticoagulants in atrial fibrillation patients with chronic kidney disease. Hart RG, Eikelboom JW, Ingram AJ, Herzog CA. Nat Rev Nephrol. 2012 Oct;8(10):569-78.
  15. Propagation of Human Prostate Cancer Stem-Like Cells Occurs through EGFR-Mediated ERK Activation.Rybak AP, Ingram AJ, Tang D.PLoS One. 2013 Apr 19;8(4):e61716.
  16. Colchicine Attenuates Renal Injury in a Model of Hypertensive Chronic Kidney Disease. Guan T, Gao B, Chen G, Chen X, Janssen M, Uttarwar L, Ingram AJ, Krepinsky JC.Am J Physiol Renal Physiol. 2013 Aug 14. [Epub ahead of print]
  17. Regulation of the tumor suppressor PTEN through exosomes: a diagnostic potential for prostate cancer. Gabriel K, Ingram A, Austin R, Kapoor A, Tang D, Majeed F, Qureshi T, Al-Nedawi K.PLoS One. 2013 Jul 25;8(7):e70047.
  18. Stroke prevention in atrial fibrillation patients with chronic kidney disease.Hart RG, Eikelboom JW, Brimble KS, McMurtry MS, Ingram AJ.Can J Cardiol. 2013 Jul;29 (7 Suppl):S71-8. Review.
  19. Caveolin-1 deficiency protects against mesangial matrix expansion in a mouse model of type 1 diabetic nephropathy. Guan TH, Chen G, Gao B, Janssen MR, Uttarwar L, Ingram AJ, Krepinsky JC.Diabetologia. 2013 Sep;56(9):2068-77.
  20. TGFβ receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cells.Chen G, Chen X, Sukumar A, Gao B, Curley J, Schnaper HW, Ingram AJ, Krepinsky JC.J Cell Sci. 2013 Aug 15;126(Pt 16):3697-712.
  21. Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease. Guan T, Gao B, Chen G, Chen X, Janssen M, Uttarwar L, Ingram AJ, Krepinsky JC. Am J Physiol Renal Physiol. 2013 Nov 15;305(10):F1466-76.
  22. Regulation of the tumor suppressor PTEN through exosomes: a diagnostic potential for prostate cancer. Gabriel K, Ingram AJ, Austin R, Kapoor A, Tang D, Majeed F, Qureshi T, Al-Nedawi K. PLoS One. 2013 Jul 25;8(7):e70047.
  23. 4-Phenylbutyrate inhibits tunicamycin-induced acute kidney injury via CHOP/GADD153 repression. Carlisle RE, Brimble E, Werner KE, Cruz GL, Ask K, Ingram AJ, Dickhout JG. PLoS One. 2014 Jan 8;9(1):e84663.