Division of Nephrology

Dr. Khalid Al-Nedawi

PhD, Medical Biology

Assistant Professor, Division of Nephrology, Department of Medicine

 

 

 

 

 

Research

Dr. Al-Nedawi has contributed to research on thrombosis and haemostasis, cancer progression, angiogenesis, metastasis and biomarkers. Dr. Al-Nedawi’s main interest is the mechanisms of intercellular interactions through exosomes / microvesicles. Identification of new biomarkers for different types of cancer is one of the major interests of Dr Al-Nedawi, with especial focus on prostate and kidney cancer. Dr. Al-Nedawi has received several awards and recognition for his scientific accomplishments. He is the winner of the 2010 Michael G. DeGroote academic fellowship award at McMaster University.

Representative peer-reviewed papers:

  1. (*) Kathleen Gabriel, Alistair Ingram, Richard Austin, Anil Kapoor, Damu Tang, Talha Qureshi and Al-Nedawi K. 2013. Regulation of the tumor suppressor PTEN through exosomes: A diagnostic potential for prostate cancer. PLOS One. 8, 7: e70047.
  2. (*) Al-Nedawi K., Meehan B., Kerbel R., Anthony C.Allison, Rak J. 2009. Endothelial Expression of Autocrine VEGF upon the Uptake of Tumour-Derived Microvesicles Containing Oncogenic EGFR. Proc Natl Acad Sci U S A. 106(10):3794-9.
  3. (*) Al-Nedawi K., Meehan B., Micaleff J., Lahotak W.,Guha Ab., Rak J. 2008. Intercellular Transfer of the Oncogenic EGFRvIII via Tumour Cell Derived Microvesicles. Nature Cell Biology. 10(5): 619-624.
  4. (*) Al-Nedawi K., Szemraj J. and Cierniewski CS. 2005. Mast Cell-Derived Exosomes Activate Endothelial Cells to Secrete Plasminogen Activator Inhibitor Type 1. Arteriosclerosis Thrombosis and Vascular Biology. 25(8): 1744-1749.
  5. (*) Al-Nedawi K., Czyz M., Bednarek M., Szemraj J., Swiatkowska M., Cierniewska-Cieslak A., Wyczolkowska J., Cierniewski CS. 2004. Thymosin β4 Induces the Synthesis of Plasminogen Activator Inhibitor-1 in Cultured Endothelial Cells and Increases Its Extracellular Expression. Blood. 103(4):1319-1324.