Division of Hematology & Thromboembolism

Agnes Y. Y. Lee

M.D., MSc, FRCP(C)

Associate Clinical Professor, Division of Hematology and Thromboembolism, Department of Medicine



Education and Professional Standing

MSc., McMaster University, 2002
F.R.C.P. (C) Hematology, 1996
F.R.C.P. (C) Internal Medicine, 1994
M.D. University of British Columbia, 1989

Research Interests

Dr. Lee is a member at the Thrombosis Service at the Hamilton Health Sciences Juravinski Hospital and Cancer Centre and is a member of the Division of Hematology and Thromboembolism. She has held several prestigious research awards including a New Investigator Award from the Canadian Institutes of Health Research/Rx&D Research Program and Research Fellowships from the Heart and Stroke Scientific Research Corporation of Canada and the Heart and Stroke Foundation of Canada.

Dr Lee’s research interest is in thrombotic disease in high-risk populations, with a focus on venous thromboembolism in patients with malignancy. She was the co-principal investigator of the CLOT in Cancer trial, a landmark study that established low-molecular-weight heparin as the treatment of choice for preventing recurrent venous thromboembolism in cancer patients. Her other research activities include studies in catheter-related thrombosis, diagnosis of deep vein thrombosis and pulmonary embolism in pregnant women, and thromboprophylaxis in patients undergoing major orthopedic surgery. She is also involved in translational research exploring the role of coagulation in cancer biology and has an interest in phase II/III development of novel anticoagulants.

Selected Publications

  1. Lee AY, Rickles FR, Julian JA, Gent M, Baker RI, Bowden C et al. A randomized comparison of low molecular weight heparin and coumarin derivatives on the surviva of patients with cancer and venous thromboembolism. J Clin Oncol 2005.
  2. Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M et al. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med 2003; 349(2):146-153.
  3. Lee AY, Levine MN. Venous thromboembolism and cancer: risks and outcomes. Circulation 2003; 107(23 Suppl 1):I17-I21.
  4. Hirsh J, Lee AY. How we diagnose and treat deep vein thrombosis. Blood 2002; 99(9):3102-3110.
  5. Lee A, Agnelli G, Buller H, Ginsberg J, Heit J, Rote W et al. Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement. Circulation 2001; 104(1):74-78.
  6. Lee AY, Julian JA, Levine MN, Weitz JI, Kearon C, Wells PS et al. Clinical utility of a rapid whole-blood D-dimer assay in patients with cancer who present with suspected acute deep venous thrombosis. Ann Intern Med 1999; 131(6):417-423.