Division of Hematology & Thromboembolism

Brian Leber


Professor, Division of Hematology and Thromboembolism, Department of Medicine

Associate Member, Department of Oncology




Dr. Brian Leber is a clinical hematologist and Professor of Medicine based at McMaster University Medical Centre and the Juravinski Cancer Centre with an interest in tlebhe pathophysiology of leukemia and investigational new drug trials. As an Associate Member of the Department of Biochemistry he collaborates with Dr. David Andrews on studies investigating basic biochemical mechanisms in apoptosis. He is also a member of the Hamilton Regional Laboratory Medicine Program and in that capacity the Director of the Molecular Hematology Laboratary. He graduated from McGill Medical School, did internal medicine at McGill, and Hematology Training at McMaster followed by a research fellowship at the Royal Free Hospital School of Medicine (University of London, UK).

Selected Publications

  1. Zhu W, Cowie A, Wasfy GW, Penn LZ Leber B, Andrews, DW Bcl-2 mutants with restricted sub-cellular location reveal spatially distinct pathways for apoptosis in different cell types. EMBO J, 15: 4130-4141, 1996.
  2. Dlugosz PJ, Billen LP, Annis MG, Zhang Z, Lin J, Leber B, Andrews, DW. Bcl-2 changes conformation to inhibit Bax oligomerization. EMBO J, 2006 June 7; 25(11):2287-96. Epub 2006 April 27.
  3. Leber B, Lin J, Andrews DW. Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes. Apoptosis, 2007 May; 12(5):897-911.
  4. Billen L, Kokoski C, Lovell J, Leber B, Andrews D. Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax. PLoS Biology, Submitted. 2007 November.