Division of Hematology & Thromboembolism

Peter L. Gross

M.D., M.Sc., FRCPC (C)

Associate Professor, Division of Hematology and Thromboembolism,
Department of Medicine

 

 

 

 

Education and Professional Standing

  • F.R.C.P. (C) Internal Medicine, 2001
  • M.D. University of Toronto, 1994
  • M.Sc. University of Toronto, 1991
  • B.Sc. University of Toronto, 1988

Research Interests

Dr. Gross is an Associate Professor at McMaster University in the Department of Medicine in the Division of Hematology and Thromboembolism. He received his B.Sc at the University of Toronto, then his M.Sc. in the Department of Biochemistry under the supervision of Dr. Margaret Rand. He obtained his M.D. from the University of Toronto in 1994, then did Core Internal Medicine training at the same institution. Dr. Gross then did clinical training in Hematology and Oncology at Beth Israel Deaconess Medical Center, a Harvard Medical School teaching hospital, in Boston, MA. Dr. Gross then spent four years as a postdoctoral fellow in the laboratory of Drs. Bruce and Barbara C. Furie at the Center for Hemostasis and Thrombosis Research at Harvard Medical School. Prior to coming to McMaster University, Dr. Gross was an Assistant Professor and Clinician Scientist in the Department of Medicine at St. Michael’s Hospital and the University of Toronto.

Through his training Dr. Gross received personal support awards from the Heart and Stroke Foundation of Ontario and the Canadian Institutes of Health Research. He was also a recipient of the Bayer Worldwide Hemophilia Awards Program, Early Career Award, 2005-2007.

Dr. Gross’s overall research interest is the pathophysiology of vascular disorders, specifically thrombosis, with a goal to develop novel strategies to treat patients with these disorders. The approach is to use experimental models of these disorders to evaluate the roles of defined cells or molecules.

His current research focuses on three key areas:

  1. cell-adhesion molecule control of fibrin in a thrombus,
  2. statin inhibition of platelet function, and
  3. antithrombin in the sepsis syndrome.

These studies are funded by, among others, the Heart and Stroke Foundation of Ontario and the Canadian Institutes of Health Research

Dr. Gross’s research approach includes studies at the levels of molecular biology, protein biochemistry, cell biology, and experimental models. The techniques utilized in his research include high-speed fluorescence widefield and confocal intravital microscopy, isolation and functional studies on leukocytes and platelets, flow cytometry, enzyme kinetics, tissue culture, and protein expression and purification.

Selected Publications

  1. Gross PL and Aird WC: The endothelium and thrombosis. Semin Thromb Hemostas 26:463-478, 2000
  2. Falati S, Gross PL, Merrill-Skoloff G, Furie BC, Furie, B: Real-time imaging of the assembly of platelets, tissue factor and fibrin during arterial formation in the mouse. Nature Med 8:1175-81, 2002
  3. Falati S, Liu Q, Gross PL, Chan J, Merrill-Skoloff G, Croce K, Furie BC, Furie B: Accumulation of tissue factor Into developing thrombi in vivo Is dependent upon microparticle P-selectin Glycoprotein Ligand 1 and platelet P-selectin. J Exp Med 197:1585-1598, 2003
  4. Reheman A, Gross PL, Yang H, Chen P, Allen D, Leytin V, Freedman J, Ni H. Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation. J Thromb Haemostas 3:875-83, 2005
  5. Gross PL, Furie BC, Merrill-Skoloff G, Chou J, Furie B. Leukocyte- versus microparticle-mediated tissue factor transfer during arteriolar thrombus development. J Leukocyte Biol 78:1318-26, 2005
  6. Falati S, Patil S, Gross PL, Stapleton M, Merrill-Skoloff G, Barrett NE, Pixton KL, Weiler H, Cooley B, Newman DK, Newman PJ, Furie BC, Furie B, Gibbins JM. Platelet PECAM-1 inhibits thrombus formation in vivo. Blood 107:535-41, 2006