Division of Geriatric Medicine

Alexandra Papaioannou

BScN, MD, MSc, FRCP(C), FACP

Professor, Division of Geriatric Medicine, Department of Medicine

Chairholder, Eli Lilly Canada Chair in Osteoporosis

 

 

 

 

Education and Professional Standing

Dr. Alexandra Papaioannou is a Professor of Medicine at McMaster University in the Division of Geriatric Medicine and a Geriatric Medicine Specialist at Hamilton Health Sciences - St Peter’s Hospital. Dr. Papaioannou holds a joint appointment in the Division of Rheumatology and is an associate member in the Department of Clinical Epidemiology and Biostatistics, and Medical Sciences. She is the past Director of the Division of Geriatric Medicine, McMaster University. Dr. Papaioannou is a Canadian Institutes of Health (CIHR) and Eli-Lilly Research Chair. She completed a Masters of Science (MSc), Health Research Methods at McMaster University.

Dr. Papaioannou was awarded an Ontario Career Scientist Award and has served on a number of Ontario Ministry of Health and Long Term Care (MOH LTC) committees; including serving as the Co-Chair of the MOH LTC Osteoporosis Strategy for Ontario, a public health initiative to prevent and reduce the impact of osteoporosis, fractures and falls. Her research focuses on the impact of fractures, falls and frailty. She is the lead investigator for the Long-term Care Ontario Osteoporosis Strategy, Co-Director of the Hamilton Canadian Multi-Centre Osteoporosis Study (CaMos), and leading the Fracture Think Osteoporosis project, a chronic disease management program in Hamilton, Ontario. Dr. Papaioannou is past Chair of the Scientific Advisory Council of Osteoporosis Canada (OC) and Chair of the Board. Dr. Papaioannou is a member of the Scientific Advisors of the International Osteoporosis Foundation.

Dr. Papaioannou has received a number of awards including the Department of Medicine Teaching Award for Postgraduate Teaching, the Ontario College of Family Physicians Certificate of Recognition for her contributions to primary care, the YWCA Hamilton Women of Distinction Award – Health & Wellness, and the Lindy Fraser Award from Osteoporosis Canada.

Dr. Papaioannou is the author of more than 200 peer reviewed publications. She co-chaired the 2010 Osteoporosis Canada Clinical Practice Guidelines (CMAJ 2010), and received a CIHR grant to develop guidelines for frail seniors. She holds a number of CIHR grants with a focus on knowledge translation in the community and long-term care.

Selected Publications

  1. Papaioannou A, Kennedy CC, Ioannidis G, Brown JP, Pathak A, Hanley DA, Josse RJ, Sebaldt R, Olszynski WP, Tenenhouse A, Murray TM, Petrie A, Goldsmith CH, Adachi JD.  Determinants of health-related quality of life in women with vertebral fractures.  Osteoporosis Int, 2006;17(3):355-363.
  2. Richards JB, Papaioannou A, Adachi JD, Joseph L, Whitson H, Prior JC, Goltzman D. Effect of selective serotonin reuptake inhibitors on the risk of fracture. Arch Int Med. 2007; 167(2):188-194.
  3. Papaioannou A, Kennedy CC, Dolovich L, Lau E, Adachi JD.  Patient Adherence with   Osteoporosis Medications:  Problems, Consequences and Management Strategies.  Drugs Aging. 2007;24(1):37-55.
  4. Ioannidis G, Papaioannou A, Thabane L, Gafni A, Hodsman A, Kvern B, Johnstone D, Plumley N, Crowley C, Baldwin A, Doupe M, Katz A, Salach L, Adachi J.  Rationale, Methods, and Feasibility of the Canadian Quality Circles (CQC) Project: An Integrated Disease Management Process.  Can Fam Physician.  2007 Oct;53:1694-1700.
  5. Papaioannou A, Kennedy C, Ioannidis G, Gao Y, Sawka AM, Goltzman D, Tenenhouse A, Pickard L, Olszynski WP, Davison KS, Kaiser S, Josse RG, Kreiger N, Hanley DA, Prior JC, Brown JP, Anastassiades T, Adachi JD, CaMos Research Group.  The Osteoporosis Care Gap in Men with Fragility Fractures: The Canadian Multicentre Osteoporosis Study.  Osteoporos Int. 2007 19:581-587.
  6. Lau E, Papaioannou A, Dolovich L, Adachi J, Sawka AM, Burns S, Nair K, Pathak A. Patients’ adherence to osteoporosis therapy: Exploring the perceptions of postmenopausal women. Can Fam Physician. 2008 Mar;54(3):394-402.
  7. Verhovsek M, Motlagh B, Crowther MA, Kennedy C, Dolovich L, Campbell G, Wang L, Papaioannou A.  Quality of anticoagulation and use of warfarin-interacting medications in long-term care:  A chart review.  BMC Geriatr. 2008 Jul 3;8:13.
  8. Papaioannou A, Kennedy C, Freitag A, Ioannidis G, O’Neill J, Webber C, Pui M, Berthiaume Y, Rabin HR, Paterson N, Jeanneret A, Matouk E, Villeneuve J, Nixon M, Adachi JD.  Alendronate Once Weekly for the Prevention and Treatment of Osteoporosis in Canadian Adult Cystic Fibrosis Patients (CFOS Trial).  Chest 2008 Oct;134(4):794-800.
  9. Papaioannou A, Kennedy C, Freitag A, O’Neill J, Pui M, Ioannidis G, Webber C, Pathak A, Hansen S, Hennessey R, Adachi JD.  Longitudinal analysis of vertebral fracture and BMD in a Canadian cohort of adult cystic fibrosis patients.  BMC Musculoskelet Disord.  2008 Sep 19;9:125.
  10. Oliver D, Papaioannou A, Giangregorio L, Thabane L, Reizgys K, Foster G. A systematic review and meta-analysis of studies using the STRATIFY tool for prediction of falls in hospital patients: how well does it work?Age and Ageing.2008 Nov;37(6):621-7.
  11. Papaioannou A, Kennedy CC, Cranney A, Hawker G, Brown JP, Kaiser SM, Leslie WD, O’Brien CJM, Sawka AM, Khan A, Siminoski K, Tarulli G, Webster D, McGowan J, Adachi JD.  Risk factors for low BMD in healthy men age 50 years or older: a systematic review.  Osteoporosis Int. 2009; 20:507-518 DOI 10.1007/s00198-008-0720-1.
  12. Papaioannou A, Kennedy C, Ioannidis G, Sawka A, Hopman W, Pickard L, Brown JP, Josse RG, Kaiser S, Anastassiades T, Goltzman D, Papadimitropoulos M., Tenenhouse A, Prior JC, Olszynski WP, Adachi JD, for the CaMos Study Group.  The impact of incident fractures on health-related quality of life:  5 years of data from the Canadian Multicentre Osteoporosis Study.  Osteoporosis International (2009) 20:703–714.
  13. Giangregorio LM, Jantzi M, Papaioannou A, Hirdes J, Maxwell CJ, Poss JW. Osteoporosis management among residents living in long-term care. Osteoporosis Int. 2009 Sep;20(9):1471-8.
  14. Papaioannou A, Kennedy CC, Cranney A, Hawker G, Brown JP, Kaiser SM, Leslie WD, O’Brien CJM., Sawka AM, Khan A., Siminoski K, Tarulli G., Webster D., McGowan J, Adachi  JD.  Risk factors for low BMD in healthy men age 50 years or older: a systematic review.  Osteoporosis Int 2009 Apr;20(4):507-18.
  15. Ioannidis G, Papaioannou A, Thabane L, Gafni A, Hodsman A, Kvern B, Walsh A, Jiwa F, Adachi JD.  Family physicians’ personal and practice characteristics that are associated with improved utilization of bone mineral density testing and osteoporosis medication prescribing.  Population Health Manag. 2009 Jun;12(3):131-8.
  16. Ioannidis G, Papaioannou A, Thabane L, Gafni A, Hodsman A, Kvern B, Walsh A, Jiwa F, Adachi JD.  The utilization of appropriate osteoporosis medications improves following a multifaceted educational intervention:  the Canadian quality circle project (CQC).  BMC Med Educ. 2009 Aug 6;9:54.
  17. Ioannidis G, Papaioannou A, Hopman WM, Akhtar-Danesh N, Anastassiades T, Pickard L, Kennedy CC, Prior JC, Olszynski WP, Davison KS, Goltzman D, Thabane L, Gafni A, Papadimitropoulos EA, Brown JP, Josse RG, Hanley DA, Adachi JD.  Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study.  CMAJ 2009. DOI:10.1503/cmaj.081720.
  18. Abid S, Papaioannou A.  Vertebral Compressions Fractures Among Older Adults. Geriatrics and Aging Jan/Feb 2009; 12(1): 10-20.
  19. Leslie WD, O’Donnell S, Jean S, Lagace C, Walsh P, Bancej C, Morin S, Hanley DA, Papaioannou A. for the Osteoporosis Surveillance Expert Working Group. Trends in Hip Fracture Rates in Canada. JAMA 2009 Aug 26;302(8):883-889.
  20. Giangregorio LM, Thabane L, deBeer J, Farrauto L, McCartney N, Adachi JD, Papaioannou A. Body weight- supported treadmill training for patients with hip fracture: a feasibility study. Arch Phys Med Rehabil 2009;90:2125-30.
  21. Jaglal SB, Hawker G, Cameron C, Canavan J, Beaton D, Bogoch E, Jain R, Papaioannou A; members of the Osteoporosis Research, Monitoring and Evaluation Working Group.  The Ontario Osteoporosis Strategy: implementation of a population-based osteoporosis action plan in Canada. Osteoporosis Int 2010 Jun;21(6):903-8
  22. Papaioannou A, Kennedy CC, Campbell G, Stroud J, Wang L, Dolovich L, Crowther MA and the Improving Prescribing in Long Term Care Investigators. A team-based approach to warfarin management in long term care: A feasibility study of the MEDeINR electronic decision support system. BMC Geriatr2010 Jun 10; 10:38
  23. Papaioannou A, Kennedy CC, Campbell G, Stroud J, Wang L, Dolovich L, Crowther MA and the Improving Prescribing in Long Term Care Investigators. A team-based approach to warfarin management in long term care: A feasibility study of the MEDeINR electronic decision support system. BMC Geriatr2010 Jun 10; 10:38
  24. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD for the Scientific Advisory Council of Osteoposis Canada.  2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary.  CMAJ. 2010 Nov 23;182(17):1864-73.
  25. Jamal SA, Swan VJ, Brown JP, Hanley DA, Prior JC, Papaioannou A, Langsetmo L, Josse RG; Canadian Multicentre Osteoporosis Study Research Group. Kidney function and rate of bone loss at the hip and spine: the Canadian Multicentre Osteoporosis Study. Am J Kidney Dis. 2010 Feb;55(2):291-9.
  26. Sawka AM, Ismaila N, Raina P, Straus S, Adachi JD, Gafni A, Papaioannou A. Hip fracture prevention strategies in long-term care: A survey of Canadian physicians’ opinions. Can Fam Phys. 2010 Nov;56(11):e392-7.
  27. Papaioannou A, Kennedy CC, Giangregorio L, Ioannidis G, Pritchard J, Hanley DA, Farrauto L, DeBeer J, Adachi JD. A randomized controlled trial of vitamin D dosing strategies after acute hip fracture: no advantage of loading doses over daily supplementation. BMC Musculoskelet Disord. 2011 Jun 20;12:135.
  28. Cheung AM, Papaioannou A; Osteoporosis Canada Scientific Advisory Council Guidelines Committee. Bone-density testing interval and transition to osteoporosis. N Engl J Med. 2012 Apr 19;366(16):1546; author reply 1547-8.
  29. Kennedy CC, Ioannidis G, Giangregorio LM, Adachi JD, Thabane L, Morin SN, Crilly RG, Marr S, Josse RG, Lohfeld L, Pickard LE, King S, VanderHorst ML, Campbell G, Stroud J, Dolovich L, Sawka AM, Jain R, Nash L, Papaioannou A. An interdisciplinary knowledge translation intervention in long-term care: Study protocol for the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial. Implement Sci. 2012 May 24;7(1):48.
  30. Ioannidis G, Kennedy CC, Dykeman J, Dudziak S, Papaioannou A. Association between vitamin D3 supplementation and serum 25-hydroxyvitamin D levels in older individuals residing in long-term care in Ontario, Canada. J Am Geriatr Soc. 2012 May;60(5):985-7.
  31. Giangregorio LM, MacIntyre NJ, Thabane L, Skidmore CJ, Papaioannou A. Exercise for improving outcomes after osteoporotic vertebral fracture. Cochrane Database of Systematic Reviews 2013, Issue 1. Art. No.: CD008618. DOI: 10.1002/14651858.CD008618.pub2
  32. Pritchard JM, Papaioannou A, Tomowich C, Giangregorio LM, Atkinson SA, Beattie KA, Adachi JD, DeBeer J, Winemaker M, Avram V, Schwarcz HP. Bone mineralization is elevated and less heterogeneous in adults with type 2 diabetes and osteoarthritis compared to controls with osteoarthritis alone, Bone (2013) 54:76-82.
  33. Ioannidis G, Flahive J, Pickard L, Papaioannou A, Chapurlat RD, Saag KG, Silverman S, Anderson FA Jr, Gehlbach SH, Hooven FH, Boonen S, Compston JE, Cooper C, Díez-Perez A, Greenspan SL, Lacroix AZ, Lindsay R, Netelenbos JC, Pfeilschifter J, Rossini M, Roux C, Sambrook PN, Siris ES, Watts NB, Adachi JD; GLOW Investigators. Non-hip, non-spine fractures drive healthcare utilization following a fracture: the Global Longitudinal Study of Osteoporosis in Women (GLOW). Osteoporos Int. 2013 Jan;24(1):59-67.