Dr. Jihong Chen

Division of Gastroenterology

Dr. Jihong Chen

M.D., PhD.

Assistant Professor, Division of Gastroenterology, Department of Medicine

 

 

 

 

 

Education and Professional Standing

Dr. Chen received her M. D., Master’s Degree and PhD degree at Wuhan University School of Medicine (known as Hubei Medical College and Hubei Medical University before 2000) in China. She received 5-year Gastroenterology and Hepatology training at McMaster University in Canada. She worked as a gastroenterologist and a full professor of medicine in the Department of Gastroenterology in Renmin Hospital of Wuhan University in China before her Canadian training.

Dr. Chen is a gastroenterologist in the Division of Gastroenterology with a special focus on gastrointestinal dysmotility. She runs a Colonic Motility Clinic at McMaster University Medical Center (MUMC) for patients with chronic constipation, defecation disorders and fecal incontinence. She runs the human gastrointestinal (GI) investigation lab with routine services of high-resolution esophageal manometry, 24-hour esophageal pH ± impedance monitoring, anorectal manometry, anorectal biofeedback training and hydrogen breath testings.

Under her clinical research projects, Dr. Chen provides 84-channel High Resolution Colonic Manometry (HRCM; the only one in North America) with the assistance of colonoscopy or fluoroscopy to evaluate pan-colonic motility, including pre-operative assessment; she also performs Barostat measurements for rectal motor and sensory functions and sacral neuromodulation for the diagnosis and treatment of severe colonic dysmotility in adults and children.

Dr. Chen has received training in Low Level Laser Therapy (LLLT) in Toronto, acupuncture in China and at McMaster Univ., TENS (Transcutaneous electrical nerve stimulation) in China and at the University of Texas Medical Branch (USA).

Dr. Chen has been extensively involved in medical teaching and training in China and in Canada during her entire medical career.

Research Interests

Dr. Chen did extensive gastrointestinal motility-related translational research during her Master’s degree study, her PhD degree study, and 2 years basic research at the University of Texas Medical Branch in Galveston (USA). She was the principle investigator of a grant from the National Natural Science Foundation of China (NSFC) and a co-clinical investigator on a Hamilton Academic Health Sciences Organization (HAHSO) grant in Canada. She is an expert on animal and human colonic motor patterns, as well as their clinical relevance. She started High Resolution Colonic Manometry (HRCM) for adult and pediatric patients at McMaster University in 2015. The HRCM evaluates the capabilities and inabilities of colon motility, the neurogenic and myogenic impairments of the colon, the correlation between patient’s autonomic nervous system activity and the colonic motor patterns, as well as the colonic responses to physiological stimulations, pharmacological agents, and non-invasive sacral neuromodulation such as Low Level Laser Therapy (LLLT) and Transcutaneous Electrical Nerve Stimulation (TENS). Dr. Chen provides diagnostic and therapeutic advice based on HRCM results.

Selected Publications

  1. Chen J-H & Huizinga JD (2018). High-Pressure Tactic: Colonic Manometry in Chronic Constipation. Dig Dis Sci 63, 1820–2822.

  2. Chen J-H, Parsons SP, Shokrollahi M, Wan A, Vincent AD, Yuan Y, Pervez M, Chen WL, Xue M, Zhang KK, Eshtiaghi A, Armstrong D, Bercik P, Moayyedi P, Greenwald E, Ratcliffe EM & Huizinga JD (2018). Characterization of simultaneous pressure waves as biomarkers for colonic motility assessed by high-resolution colonic manometry. Frontiers in Physiology, Gastrointestinal Sciences 9:1248, DOI: 10.3389/fphys.2018.01248.

  3. Chen J-H, Yu Y, Yang Z, Yu W-Z, Chen WL, Kim MJM, Huang M, Tan S, Luo H, Chen J, Chen JDZ & Huizinga JD (2017). Intraluminal pressure patterns in the human colon assessed by high-resolution manometry. Nature’s Scientific Reports 7, 41436; doi:10.1038/srep41436.

  4. Chen J-H, Yang Z, Yu Y & Huizinga JD (2016). Haustral boundary contractions in the proximal 3-taeniated colon of the rabbit. Am J Physiol 310, G181–192.

  5. Chen JH, Wang XY, Liu LW, Yu W, Yu Y, Zhao L & Huizinga JD (2013a). On the origin of rhythmic contractile activity of the esophagus in early achalasia, a clinical case study. Front Neurosci 7-77, 1–10.

  6. Chen JH, Zhang Q, Yu Y, Li K, Liao H, Jiang LS, L. H, Hu X, Chen S, Yin S, Gao Q, Yin X, Luo H & Huizinga JD (2013b). Neurogenic and myogenic properties of pan-colonic motor patterns and their spatiotemporal organization in rats. PLoS ONE 8, e60474, doi: 10.3389/fphys.2015.00205.

  7. Huizinga JD, Mathewson KJ, Yuan Y & Chen J (2018). Probing heart rate variability to determine parasympathetic dysfunction. Physiological Reports 6, e13713.

  8. Li H, Chen JH, Yang Z, Huang M, Yu Y, Tan S, Luo H & Huizinga JD (2016). Neurotensin changes propulsive activity into a segmental motor pattern in the rat colon. Journal of Neurogastroenterology and Motility 10.5056/jnm15181.

  9. Quan X, Yang Z, Xue M, Chen J-H & Huizinga JD (2017). Relationships between motor patterns and intraluminal pressure in the 3-taeniated proximal colon of the rabbit. Nature’s Scientific Reports 7:42293, doi:10.1038/srep42293.

  10. Yu Y, Chen JH, Li H, Yang Z, Du X, Hong L, Liao H, Jiang L, Shi J, Zhao L, Tan S, Luo H & Huizinga JD (2015). Involvement of 5-HT3 and 5-HT4 receptors in colonic motor patterns in rats. Neurogastroenterol Motil 27, 914–928.

  11. Chen, J-H., H. S. Sallam, L. Lin, and J. D. Chen. Colorectal and rectocolonic reflexes in canines:       involvement of tone, compliance, and anal sphincter relaxation. Am J Physiol Regul Integr Comp Physiol 2010;299:R953-9.

  12. Chen J-H, SZ Wei, J Chen, Q Wang, HL Liu, XH Ga, GC li, WZ yu, M Chen, HS Liu. Sensory denervation reduces visceral hypersensitivity in adult rats exposed to chronic unpredictable stress: evidences of neurogenic inflammation. Dig. Dos. Sci 2009 54: 1884-1981.