Division of Gastroenterology

Bruno Salena


Associate Professor, Division of Gastroenterology, Department of Medicine






Education and Professional Standing

Dr. Salena attended the University of Toronto graduating with a B.A. (1976) and M.S.W. (1978). He completed his M.D. (1981) at McMaster University where he continued his postgraduate studies in Epidemiology and Biostatistics and further postgraduate training in Internal Medicine and Gastroenterology. He additionally completed an Advanced Endoscopy Fellowship (1988) at the Cleveland Clinic under the mentorship of Dr. Michael V. Sivak Returning to McMaster University in 1988 he was appointed to the full-time faculty of Division of Gastroenterology, Faculty of Health Sciences and consultant staff at Hamilton Health Sciences. He is a past president of the Hamilton Health Sciences Medical Staff Association and the founding and past President of the Ontario Association of Gastroenterology

Dr. Salena has published numerous peer-reviewed articles and book chapters. He has served as an associate editor of the journals, Evidence Based Medicine and JAMA Journal Club. He is actively involved as a teacher in the undergraduate MD and postgraduate MD programs at McMaster University. Dr. Salena is a clinical trials co-investigator in digestive diseases at McMaster University with clinical interests in interventional endoscopy, colorectal cancer screening, dyspepsia and inflammatory bowel disease

Current research interests include discovery and development of new biomarkers for gastrointestinal diseases.  The currently funded projects include the development of microbiome-based biosensors for the early detection of colorectal cancer, discovery of biomarkers for the targeting and early detection of ALS and biosensors for the rapid detection and tracking of C. difficile infections.

Selected Publications

  1. Zhang W, Liu M, Lee C, Salena BJ, Yi L.  Serendipitous Discovery of a Guanine-rich DNA Molecule with a Highly Stable Structure in Urea. Nature Scientific Reports 2018 (1935) doi:10/1038/s41598-018-20248-w
  2. Chang D, Tram K, Li B, Feng Qian, Shen Z, Lee CH, Salena BJ, and Li Y. Detection of DNA Amplicons of Polymerase Chain Reaction Using Litmus Test. Nature Sci Rep 2017;7:3110.
  3. Tram K, Manochehry S, Feng Q, Chang D, Salena BJ, Li Y. Colourimetric Detection of Bacteria Using Litmus Test. J Vis Exp 2016;115:e54546, doi:10.3791/54546.
  4. Wu Z, Tram K, Salena BJ, Li Y. Topological DNA Assemblies Containing Identical or Fraternal Twins. ChemBioChem 2016;17:1142-5.
  5. Shen Z, Wu Z, Chang D, Zhang W, Tram K, Lee C, Kim P, Salena BJ, Li Y. A Catalytic DNA Activated by a Specific Strain of Bacterial Pathogen. Angew Chem Int Ed 2016 [in press].
  6. Mao Y, Liu M, Tram K, Gu J, Salena BJ, Jiang Y, Li Y. Optimal DNA Templates for Rolling Circle Amplification Revealed by In Vitro Selection. Chem Euro J 2015;21:8069-74.
  7. Tram, K., Kanda, P., Salena, B. J., Huan, S., Li, Y. Translating bacterial detection into a litmus test. Angew Chem Int Ed 2014;53:12799-802. doi:10.1002/anie.201407021. Very Important Paper (top 5% papers). Featured as the Back Cover.
  8. Wang, L., Tram, K., Ali, M. M., Salena, B., Li, J., Li, Y. Arrest of Rolling Circle Amplification by DNA Aptamers. Chemistry 2014;20:2420-4. doi: 10.1002/chem.201304292.
  9. A Sensitive DNA Enzyme-Based Fluorescent Assay for Bacterial Detection.  Aguirre SD, Ali MM, Salena BJ, Li Y. Biomolecules 2013;3:563-77.
  10. Sumanac K, Zealley I, Fox BM, Rawlinson J, Salena B, Marshall JK, Stevenson GW, Hunt RH. Minimizing postcolonoscopy abdominal pain by using CO2 insufflation: a prospective, randomized, double blind, controlled trial evaluating a new commercially available CO2 delivery system. Gastrointest Endosc. 2002;56:190-4.