Division of Gastroenterology

Grigorios I. Leontiadis

MD, PhD

Associate Professor, Division of Gastroenterology, Department of Medicine

Administrative Assistant: Cassandra Popek
905.521.2100 X73836
popekcl@mcmaster.ca

Academic Biography

Dr Grigorios Leontiadis qualified from Aristotle University of Thessaloniki, Greece in 1992 and trained in Gastroenterology in Greece (Papanikolaou Hospital, Thessaloniki) and in the UK (Royal Albert Infirmary, Wigan and Queen Elizabeth Hospital, Gateshead).  He was awarded a PhD in 2002 from the Democritus University of Thrace, Greece (title of PhD thesis: The effect of H. pylori infection on gastric emptying in patients with functional dyspepsia). He worked for a short period as a Consultant Gastroenterologist at the University Hospital of North Durham, UK and then moved to Greece where he worked in private practice while being a Research Associate at the Aristotle University of Thessaloniki. In 2006 he was appointed Consultant Gastroenterologist & Senior Lecturer in Internal Medicine at the Democritus University of Thrace, Alexandroupolis. In 2008 he moved to McMaster University, Hamilton, Canada as Assistant Professor in the Department of Medicine.

Dr Leontiadis has published 28 peer-reviewed articles and 2 book chapters.  He is an advocate of evidence based medicine and is the deputy co-ordinating editor and criticism editor of the Upper Gastrointestinal and Pancreatic Diseases Cochrane Group.  He has been involved in the development of the Hellenic and the international guidelines on the management of non-variceal upper gastrointestinal bleeding.

Research Interests

His research interests include pharmacological treatment of peptic ulcer disease, pathophysiology and treatment of H. pylori infection, prevention of upper gastrointestinal side-effects of non steroidal anti-inflammatory drugs and diagnostic utility of small bowel capsule endoscopy. He was the lead author of the National Institute for Health Research (UK) Health Technology Assessment Programme on the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding (2005-2007).

Selected Publications

  1. Leontiadis GI, Sreedharan A, Dorward S, Barton P, Delaney B, Howden CW, Orhewere M, Gisbert J, Sharma VK, Rostom A, Moayyedi P, Forman D. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding. Health Technol Assess 2007; 11(51): 1-164

  2. Leontiadis GI, Sharma VK, Howden CW. Proton pump inhibitor therapy for peptic ulcer bleeding: Cochrane collaboration meta-analysis of randomized controlled trials. Mayo Clin Proc 2007; 82: 286-96

  3. Dorward S, Sreedharan A, Leontiadis GI, Howden CW, Moayyedi P, Forman D. Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding. Cochrane Database Syst Rev 2006; (4): CD005415

  4. Leontiadis GI, Sharma VK, Howden CW. Proton pump inhibitor treatment for acute peptic ulcer bleeding. Cochrane Database Syst Rev 2006; (1): CD002094

  5. Triester SL, Leighton JA, Leontiadis GI, Gurudu SR, Fleischer DE, Hara AK, Heigh RI, Shiff AD, Sharma VK. A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn's disease. Am J Gastroenterol 2006; 101: 954-64.

  6. Triester SL, Leighton JA, Leontiadis GI, Fleischer DE, Hara AK, Heigh RI, Shiff AD, Sharma VK. A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with obscure gastrointestinal bleeding. Am J Gastroenterol 2005; 100: 2407-18

  7. Leontiadis GI, Sharma VK, Howden CW. Systematic review and meta-analysis of proton pump inhibitor therapy in peptic ulcer bleeding. BMJ 2005; 330: 568-70

  8. Leontiadis GI, Sharma VK, Howden CW. Systematic review and meta-analysis: enhanced efficacy of proton-pump inhibitor therapy for peptic ulcer bleeding in Asia - a post hoc analysis from the Cochrane Collaboration. Aliment Pharmacol Ther 2005; 21: 1055-61

  9. Leontiadis GI, Minopoulos GI, Maltezos E, Kotsiou S, Manolas KI, Simopoulos K, Hatseras D. Effects of Helicobacter pylori infection on gastric emptying rate in patients with non-ulcer dyspepsia. World J Gastroenterol 2004; 10: 1750-4

  10. Leontiadis GI, McIntyre L, Sharma VK, Howden CW. Proton pump inhibitor treatment for acute peptic ulcer bleeding. Cochrane Database Syst Rev 2004; (3): CD002094

  11. Levine JE, Leontiadis GI, Sharma VK, Howden CW. Meta-analysis: the efficacy of intravenous H2-receptor antagonists in bleeding peptic ulcer. Aliment Pharmacol Ther 2002; 16: 1137-42

  12. Sharma VK, Leontiadis GI, Howden CW. Meta-analysis of randomized controlled trials comparing standard clinical doses of omeprazole and lansoprazole in erosive oesophagitis. Aliment Pharmacol Ther 2001; 15: 227-31

  13. Leontiadis GI, Sharma VK, Howden CW. Non-gastrointestinal tract associations of Helicobacter pylori infection. Arch Intern Med 1999; 159: 925-40