Department of Medicine

Dr. Ayesha Ghayur


Assistant Clinical Professor (Adjunct), Department of Medicine

Phone  289 339 6932





Education and Professional Standing

  • Post-Doctoral Training: Division of Nephrology, St. Joseph's Hospital, McMaster University, 2013-2014
  • Graduate Studies (PhD, Medical Sciences): McMaster University, 2007-2013
  • Research Fellowship: Ludwig Institute for Cancer Research, University College London, UK, 2004
  • Research Fellowship: Department of Biochemistry, Drexel University, Philadelphia, USA, 2001
  • Undergraduate (MBBS): Aga Khan University Medical College, Karachi, Pakistan, 1999-2004

Academic Interests

  • MD Program (Medical Foundations, years 1& 2): School of Medicine, 2011-to present
  • Tutor BScN (Biochemistry): School of Nursing, 2010-2011
  • Tutor BHSc Midwifery (Anatomy/Physiology): Midwifery Education Program, 2008-2009

Research Interests

  • Role of transforming growth factor beta in proteinuria
  • Fibrotic pathways involved in mouse glomerulonephritis model 
  • Proteinuria and podocyte de-differentiation
  • Epithelial to mesenchymal transition in fibrosis

Selected Publications

  1. Chen G, Wang T, Uttarwar L, vanKrieken R, Li R, Chen X, Gao B, Ghayur A, Margetts P, Krepinsky JC. SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells. J Mol Cell Biol 2014; 6: 516-30.
  2. Siddique I, Curran S, Ghayur A, Liu L, Hoff CM, Gangji A, Brimble S, Margetts PJ. Gremlin induces peritoneal membrane injury and is associated with increased solute transport. Am J Pathol 2014; 184: 2976-84.  
  3. Ghayur A, Margetts PJ. Transforming growth factor-beta and the glomerular filtration barrier. Kidney Res Clin Pract 2013; 32: 3-10.
  4. Ghayur A, Liu L, Kolb M, Chawla A, Lambe S, Kapoor A, Margetts PJ. Adenovirus-mediated gene transfer of TGF-β1 to the renal glomeruli leads to proteinuria. Am J Pathol 2012; 180: 940-51.
  5. Liu L, Shi CX, Ghayur A, Zhang C, Su JY, Hoff CM, Margetts PJ. Prolonged peritoneal gene expression using a helper-dependent adenovirus. Perit Dial Int 2009; 29: 508-16.
  6. Ghayur MN, Ghayur A, Janssen LJ. State of clinical research ethics in Pakistan. Nat Med 2007; 13: 1011.