Dr. Greg Steinberg

Division of Endocrinology & Metabolism

Gregory Steinberg


Professor, Division of Endocrinology, Department of Medicine

Canada Research Chair in Metabolism and Obesity

J. Bruce Duncan Chair in Metabolic Diseases

Co-Director, Metabolism and Childhood (MAC) Obesity Research Program (//fhs.mcmaster.ca/macobesity/)


Education and Professional Standing

Dr. Steinberg obtained his PhD in 2002 from the University of Guelph.   His research thesis was conducted in the laboratory of Professor David Dyck where he studied the regulation of metabolism in muscle by the hormone leptin.  From 2002-2006, Dr. Steinberg conducted Postdoctoral Research in the laboratory of  Professor Bruce Kemp at St. Vincent’s Institute of Medical Research in Melbourne, Australia.  During this time he gained insight into protein biochemistry and molecular biology with an emphasis on the metabolic stress sensing protein kinase AMPK.  In 2006, Dr. Steinberg became Head of the Metabolism Unit at St. Vincent’s Institute of Medical Research and a Senior Fellow of the National Health and Medical Research Council of Australia.   In 2009, Dr. Steinberg returned to Canada and joined the Department of Medicine, Endocrinology and Metabolism Division as an Associate Professor and Canada Research Chair.  His laboratory is currently funded by grants from CFI, CIHR, CDA and NSERC. 

Selected Publications

  1. Pinkosky SL, Newton RS, Day EA, Ford RJ, Lhotak S, Austin RC, Birch CM, Smith B, Filippov S, Groot PH, Steinberg GR*, and Lalwani ND. Liver specific ATP-citrate lyase inhibition by bempedoic acid (ETC-1002) reduces LDL-C and atherosclerosis.  Nature Communications.7:13457, 2016. https://www.ncbi.nlm.nih.gov/pubmed/27892461
  2. Mottillo EP, Desjardins EM, Crane JD, Smith BK, Green AE, Ducommun S, Henriksen TI, Rebalka IA, Razi A, Sakamoto K, Scheele C, Kemp BE, Hawke TJ, Ortega J, Granneman JG, Steinberg GR.  Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.  Cell Metabolism.  24(1):118-29, 2016.
  3. Bujak AL, Crane JD, Ford RJ, Kang SJ, Lally JS, Kemp BE, Hawke TJ, Schertzer JD, Steinberg GR.  AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging.  Cell Metabolism, 21(6):883-90, 2015. 
  4. Crane JD, Palanivel R, Mottillo EP, Bujak AL, Wang H, Ford RJ, Collins A, Blümer RM, Fullerton MD, Yabut JM, Kim JJ, Ghia JE, Hamza SM, Morrison KM, Schertzer JD, Dyck JR, Khan WI and Steinberg GR.  Inhibiting peripheral serotonin synthesis reduces obesity and the metabolic dysfunction by promoting brown adipose tissue thermogenesis.  Nature Medicine. 21(2):166-72, 2015.
  5. Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen Z-P, O;Neill HM, Rengasamy P, O’Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, Van Denderen BJ, Kemp BE, Steinberg GR. A single phosphorylation site in ACC1 and ACC2 is essential for lipid homeostasis and the insulin sensitizing effects of metformin. Nature Medicine. 19(12):1649-54, 2014. http://www.nature.com/nm/journal/v19/n12/full/nm.3372.html
  6. Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie GD. The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase. Science, 18:336 (6083):918-22, 2012. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399766/
  7. Galic S, Fullerton MD, Schertzer JD, Sikkema S, Marcinko K, Honeyman J, Walkley CR, Chen Z-P, van Denderen BJ, Kemp BE, Steinberg GR.  Hematopoietic AMPK β1 prevents inflammation and hepatic insulin resistance in obesity.  Journal of Clinical Investigation. 121(12):4903-15, 2011. http://www.jci.org/articles/view/58577
  8. O’Neill H, Maarbjerg S, Crane J, Jeppesen J, Jørgensen SB, Shyroka O, Schertzer J.D., vanDenderen BJ, Kiens, B., Tarnopolsky MA., Kemp BE, Richter EA, Steinberg GR. AMPK β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.  Proceedings of the National Academy of Sciences.  108(38):16092-7, 2011. http://www.pnas.org/content/108/38/16092.long
  9. Galic S, Oakhill J, Steinberg GR. The adipocyte as an endocrine organ. Molecular and Cellular Endocrinology 316(2):129-39, 2010.  http://www.sciencedirect.com/science/article/pii/S0303720709004389
  10. Steinberg GR and Kemp BE.  AMPK in Health and Disease.  Physiological Reviews. 89(3):1025-78, 2009.  http://physrev.physiology.org/content/89/3/1025.long

For all listed pubmed articles see:


For all listed Google Scholar articles see: