Gianluca Iacobellis MD, PhD

Associate Professor
Department of Medicine, Division of Endocrinology
Service of Endocrinology, St. Joseph’s Healthcare, McMaster University
Cardiovascular Obesity Research and Management, Hamilton Health Sciences, McMaster University

St. Joseph Hospital
Fontbonne Building 5 th floor
905.522.1155 X32739
gianluca@ccc.mcmaster.ca
gianluca.iaco@tin.it

Dr. Gianluca Iacobellis obtained his medical doctor degree with 110/110 cum laude from the University of Roma , La Sapienza, Italy , in 1994. He was Research Fellow at Centrum for Metabolism & Endocrinology, Huddinge University Hospital Karolinska Institutet, Stockholm , Sweden , directed by Prof Arner in 1999. Dr Iacobellis was certified as Specialist in Endocrinology and Metabolic Disorders in 2000. He obtained the PhD in Endocrinology, Metabolic and Cardiovascular Disorders from the University of Roma , La Sapienza in 2004. Dr Iacobellis was invited as Post Doctoral Clinical Research Fellow, from the Center for Human Nutrition University of Texas Southwestern Medical Center at Dallas , directed by Prof Grundy, from 2004 to 2005. He was Clinical Research Fellow in the Department of Medicine, Cardiovascular Obesity Research & Management, McMaster University , Hamilton General Hospital , under the direction of Prof Sharma from 2005 to 2006. Dr Iacobellis was certified by the College of Physicians and Surgeons of Ontario in 2005. Dr Iacobellis is recipient of the Internal Career Award, Department of Medicine, McMaster University in 2006 and Pfizer Award for Competitive Awards Program for Cardiovascular Proposals in 2003.

Dr. Iacobellis’ research interest focuses on the diagnostic, pathogenic and cardiovascular aspects of obesity and metabolic syndrome. He is involved in pursuing epicardial adipose tissue projects that have the potential to open new avenues for cardiac research in the area of obesity and obesity-related cardiovascular diseases. Dr Iacobellis is currently involved as clinical investigator in several clinical studies and pharmaceutical trials, as well as EPICARD, MOLECULAR-SHARE, TRIM, SOCCER, VICTORIA , INSPIRE ME. He is member of several endocrinology and cardiology scientific societies.

Dr. Iacobellis has authored and co-authored more than 40 peer-reviewed papers and 10 textbooks. He also lectured widely on the cardiovascular aspects of obesity and metabolic syndrome. He is part of the Editorial Board and Reviewer of several cardiology and endocrinology journals.

Peer-reviewed journal articles

1. G. Iacobellis, CM Pond, AM Sharma Different weight of cardiac and general adiposity in predicting left ventricle morphology Obesity 2006, in press
2. G. Iacobellis, AM Sharma. Obesity and the heart: redifintion of the relationship Obesity Reviews 2006, in press
3. G. Iacobellis, Sharma AM. Hypertension in obesity and normoweight subjects. Nutrition Metab Cardiov Dis 2006 in press
4. G. Iacobellis, Leonetti F, Buzzetti R. Increased Left Ventricular Mass in Uncomplicated Obese Subjects Carrying the 276 G/G Single Nucleotide Polymorphism of the Adiponectin Gene Obesity 2006; 14:368
5. G. Iacobellis, Singh N,Leonetti F, AM Sharma Relationship of epicardial adipose tissue with atrial dimensions and diastolic function in morbidly obese subjects International Journal of Cardiology 2006 June 5
6. G. Iacobellis, D Corradi, AM Sharma. Epicardial adipose tissue: anatomical, biomolecular and clinical relation to the heart. Nature Clinical Practice Cardiovascular Medicine 2005 ;2:536-43.
7. G. Iacobellis, FLeonetti. Epicardial adipose tissue and insulin resistance in obese subjects J Clin Endocrinol Metab . 2005; 90:6300-2
8. G. Iacobellis , MC Ribaudo, F Leonetti Prevalence of uncomplicated obesity in an Italian obese population Obesity Research 2005, ;13:1116-
9. G. Iacobellis True uncomplicated obesity is not related to increased left ventricular mass and systolic dysfunction. Journal of American College of Cardiology . 2004;44:2257
10. G. Iacobellis Imaging of Visceral Adipose Tissue: An Emerging Diagnostic Tool and Therapeutic Target. Current Drug Target Cardiovascular & Haematological Disorders 2005 5;4: 345-353
11. G. Iacobellis Is obesity a risk factor for atrial fibrillation? Nature Clinical Practice Cardiovascular Medicine 2005; 2: 134-5
12. G. Iacobellis, C di Gioia. Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease Cytokine. 2005; 29:251-5
13. G. Iacobellis , F Leonetti Adapted changes in left ventricular structure and function in severe uncomplicated obesity. Obesity Research 2004;12:1616-21.
14. G. Iacobellis, F Leonetti. Relation between epicardial adipose tissue and left ventricular mass . American Journal of Cardiology 2004; 94:1084-7.
15. G. Iacobellis, Leonetti F. Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clin Endocrinol (Oxf). 2005 ;62:487-91
16. G. Iacobellis, Moschetta A , Leonetti Normal serum alanine aminotransferase activity in uncomplicated obesity World Journal of Gastroenterology 2005 ;11: 6018-6021
17. G. Iacobellis , M Curione, F Leonetti. No effect of acute hyperinsulinemia on QTc interval and QTc dispersion in uncomplicated obesity. International Journal of Cardiology 2005; 99:161-3.
18. Silecchia S, Iacobellis G. Prevalence of Cancer in Italian Obese Patients Referred for Bariatric Surgery. Obesity Surgery 2005;15:1171-6
19. G. Iacobellis , F Assael, F Leonetti. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome. A new indicator of cardiovascular risk. J Clin Endocrinol Metab 2003;88:11
20. G. Iacobellis , F Leonetti. Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction Obesity Research , 11; 304-310: 2003
21. G. Iacobellis, MC Ribaudo, U Di Mario, F Leonetti. Relationship of insulin sensitivity and left ventricular mass in uncomplicated obesity Obesity Research 2003 11;518-524
22. G. Iacobellis , F Leonetti. Massive epicardial adipose tissue indicating severe visceral obesity Clin Cardiol 2003; 26 (5):237
23. F Leonetti, G Silecchia, G Iacobellis Different plasma ghrelin levels after gastric banding and gastric by pass in severe obesity J Clin Endocrinol Metab 2003 88: 4227-4231
24. G. Iacobellis , F Leonetti. Influence of excess fat on cardiac morphology and function: study in uncomplicated obesity Obesity Research 10; 767-773, 2002

Textbook and book chapters

1. G. Iacobellis Drug-drug Interactions in the metabolic syndrome Nova Publishers, USA , 2006 in press
2. G. Iacobellis and Sharma AM. Hypertension Management in diabetic obese patient. Harrison’s Principles of Internal Medicine 2006, McGraw Hill, USA
3. G. Iacobellis and Sharma AM Treatment of obesity: a challenging task in Obesity and the kidney Karger Publisher, 2006 in press

Dr. Iacobellis outpatient clinical practice is located at St. Joseph ’s Hospital and Hamilton General and is focused on Endocrinology, Obesity, Diabetes and Metabolic Syndrome