Dr. Darryl Leong

Division of Cardiology

Dr. Darryl P. Leong


Assistant Professor, Division of Cardiology, Department of Medicine

Investigator, Population Health Research Institute

Cardiologist, Hamilton Health Sciences




Dr. Leong’s research content interest is the prevention, identification, and management of cardiovascular disease in the frail and in those with complex disease and multi-morbidity. His research methodological expertise includes clinical biostatistics, epidemiology, and clinical trials. He is leading the development of a clinical and research program for the evaluation and treatment of cardiovascular disease in patients with cancer, at the Juravinski Hospital.

Dr. Leong obtained his medical degree at the University of Adelaide, Australia, graduating with Honours and Dean's Listing for academic excellence. He subsequently undertook his residency in internal medicine and cardiology at the Royal Adelaide Hospital, before completing a Master of Public Health and PhD at the University of Adelaide. Dr. Leong then completed a post doctorate fellowship in cardiovascular imaging at Leiden University Medical Centre, the Netherlands. He was a finalist for the Samuel A. Levine Young Investigator Award of the American Heart Association, 2012, and has published more than 90 peer-reviewed manuscripts. Dr. Leong has received a number of awards, most recently including the E.J.Moran Campbell AFP Internal Career Research Award, McMaster University, and is an Emerging Leader in the World Heart Federation.

Selected Publications

  1. Darryl P. Leong, Per L. Madsen, Joseph B. Selvanayagam. The Non-Invasive Evaluation of Myocardial Fibrosis: Implications for the Clinician. Heart 2010; 96: 2016-24.
  2. Darryl P. Leong, Anne-Marie Mitchell, Anthony G. Brooks, Muayad Alasady, Han S. Lim, Gautam Sharma, Ingrid Salna, Malcolm Barlow, James Leitch, Prashanthan Sanders, Glenn D. Young. Long-term mechanical consequences of permanent right ventricular pacing: Effect of pacing site. Journal of Cardiovascular Electrophysiology 2010; 21(10): 1120-6.
  3. Wong CX, Abed HS, Molaee P, Nelson AJ, Brooks AG, Sharma G, Leong DP, Lau DH, Middeldorp ME, Roberts-Thomson KC, Wittert GA, Abhayaratna W, Worthley SG, Sanders P. Pericardial Fat is Associated with Atrial Fibrillation Severity and Ablation Outcome. J Am Coll Cardiol 2011; 57(17): 1745-51.
  4. Darryl P. Leong, Adhiraj Chakrabarty, Nicholas Shipp, Payman Molaee, Per Lav Madsen, Lucas Joerg, Thomas Sullivan, Stephen G. Worthley, Carmine G. De Pasquale, Prashanthan Sanders, Joseph B. Selvanayagam. Effects of myocardial fibrosis and ventricular dyssynchrony on response to therapy in new-presentation idiopathic dilated cardiomyopathy: insights from cardiovascular magnetic resonance and echocardiography. Eur Heart J 2012; 33(5): 640-8.
  5. Rishi Puri, Gary Y.H. Liew, Stephen J. Nicholls, Adam J. Nelson, Darryl P. Leong, Angelo Carbone, Barbara Copus, Dennis T.L. Wong, John F. Beltrame, Stephen G. Worthley, Matthew I. Worthley. Coronary β2-adrenoreceptors mediate endothelium-dependent vasoreactivity in humans: novel insights from an in vivo intravascular ultrasound study. Eur Heart J 2012; 33(4): 495-504.
  6. Darryl P. Leong, Suchi Grover, Payman Molaee, Adhiraj Chakrabarty, Mitra Shirazi, Yi H. Cheng, Amy Penhall, Rebecca Perry, Hugh Greville, Majo X. Joseph, Joseph B. Selvanayagam. Non-volumetric echocardiographic indices of right ventricular systolic function: validation with cardiovascular magnetic resonance and relationship with functional capacity. Echocardiography 2012; 29(4): 455-63.
  7. Darryl P. Leong, Ulas Höke, Victoria Delgado, Dominique Auger, Joep Thijssen, Lieselot van Erven, Jeroen J. Bax, Martin J. Schalij, Nina Ajmone Marsan. Predictors of Long-Term Benefit of Cardiac Resynchronisation Therapy in Patients with Right Bundle Branch Block. Eur Heart J 2012; 33(15): 1934-41.
  8. Darryl P. Leong, Ulas Höke, Victoria Delgado, Dominique Auger, Tomasz Witkowski, Joep Thijssen, Lieselot van Erven, Jeroen J. Bax, Martin J. Schalij, Nina Ajmone Marsan. Right Ventricular Function and Survival Following Cardiac Resynchronsation Therapy. Heart 2013; 99(10): 722-8.
  9. Dennis T.L. Wong, Brian S. Ko, James D. Cameron, Nitesh Nerlekar, Michael C.H. Leung, Yuvaraj Malaiapan, Marcus Crossett, Darryl P. Leong, Stephen G. Worthley, John Troupis, Ian T. Meredith, Sujith K. Seneviratne. Transluminal attenuation gradient in CT coronary angiography is a novel non-invasive approach to the identification of functionally significant coronary artery stenosis: A comparison with fractional flow reserve (FFR). J Am Coll Cardiol 2013; 61(12): 1271-9.
  10. Darryl P. Leong, Amy Penhall, Rebecca Perry, Mitra Shirazi, Mikhail Altman, David Chong, Julie Bradley, Majo X. Joseph, Joseph B. Selvanayagam. Speckle-Tracking Strain of the Left Atrium: A Transoesophageal Echocardiographic Validation Study. Eur Heart J Cardiovasc Imaging 2013; 14(9): 898-905.
  11. Darryl P. Leong, John W. Eikelboom, Jeff S. Healey, Stuart J. Connolly. Atrial fibrillation is associated with increased mortality: causation or association? Eur Heart J 2013; 34(14):1027-30.
  12. Han S. Lim, Scott R. Willoughby, Carlee Schultz, Muayad Alasady, Dennis H. Lau, Darryl P. Leong, Anthony G. Brooks, Glenn D. Young, Peter M. Kistler, Jonathan M. Kalman, Matthew I. Worthley, Prashanthan Sanders. Effect of Atrial Fibrillation on Atrial Thrombogenesis in Humans: Impact of Rate and Rhythm. J Am Coll Cardiol 2013; 61(8): 852-60.
  13. Sebastiaan R.D. Piers, Darryl P. Leong, Carine F.B. Huls van Taxis, Mohammad Tayyebi, Serge A. Trines, Daniel A. Pijnappels, Victoria Delgado, Martin J. Schalij, Katja Zeppenfeld. Outcome of Ventricular Tachycardia Ablation in Patients with Nonischemic Dilated Cardiomyopathy: the Impact of Noninducibility. Circ Arrhythm Electrophysiol 2013; 6(3): 513-21.
  14. Philippe Debonnaire, Darryl P.Leong, Tomasz Witkowski, Ibtihal Al Amri, Emer Joyce, Spyridon Katsanos, Martin J. Schalij, Jeroen J. Bax, Victoria Delgado, Nina Ajmone Marsan. Left atrial function by 2D speckle tracking echocardiography in patients with severe organic mitral regurgitation: association with guidelines-based surgical indication and postoperative (long-term) survival. J Am Soc Echocardiogr 2013; 26(9): 1053-62.
  15. Suchi Grover, Darryl P. Leong, Adhiraj Chakrabathy, Govin Srinivasan, Lucas Joerg, Dusan Kotasek, Kerry Cheong, Rohit Joshi, Susan Kim, Amy Penhall, Majo X. Joseph, Bogda Koczwara, Joseph B. Selvanayagam. Left and Right ventricular effects of Anthracycline and Trastuzumab chemotherapy: a prospective, study using novel cardiac imaging and biochemical markers. Int J Cardiol 2013; 168(6): 5465-7.
  16. Hany S. Abed, Gary A. Wittert, Darryl P. Leong, Masoumeh G. Shirazi, Bobak Bahrami, Melissa E. Middeldorp, Michelle F. Lorimer, Dennis H. Lau, Nicholas A. Antic, Anthony G. Brooks, Walter P. Abhayaratna, Jonathan M. Kalman, Prashanthan Sanders. Effect of weight reduction and cardiometabolic risk factor management on symptom burden and severity among patients with atrial fibrillation: A randomized controlled clinical trial. JAMA 2013; 310(19): 2050-60.
  17. Emer Joyce, Georgette E Hoogslag, Darryl P Leong, Philippe Debonnaire, Spyridon Katsanos, Helèn Boden, Martin J Schalij, Nina Ajmone Marsan, Jeroen J Bax, Victoria Delgado. Association between left ventricular global longitudinal strain and adverse left ventricular remodeling after ST-segment elevation myocardial infarction. Circ Cardiovasc Imaging 2014; 7(1): 74-81.
  18. Emer Joyce, Darryl P Leong, Georgette E Hoogslag, Paul L van Herck, Philippe Debonnaire, Elena Abate, Eduard R Holman, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan. Left ventricular twist during dobutamine stress echocardiography after acute myocardial infarction: Association with reverse remodeling. Int J Cardiovasc Imaging 2014; 30(2): 313-22.
  19. Dennis TL Wong, Brian S Ko, James D Cameron, Michael CH Leung, Yuvaraj Malaiapan, Nitesh Nerlekar, Marcus Crossett, Darryl P Leong, John Troupis, Ian T Meredith, Sujith K Seneviratne. Comparison of diagnostic accuracy between combined assessment of adenosine stress CT perfusion (CTP) + computed tomography angiography (CTA) and transluminal attenuation gradient (TAG320) + CTA with fractional flow reserve (FFR). J Am Coll Cardiol 2014; 63(18): 1904-12.
  20. Darryl P. Leong, Andrew Smyth, Koon K. Teo, Martin McKee, Sumathy Rangarajan, Prem Pais, Lisheng Liu, Sonia S. Anand, Salim Yusuf. Patterns of alcohol consumption and myocardial infarction risk: observations from 52 countries in the INTERHEART case-control study. Circulation 2014; 130(5): 390-8.
  21. Darryl P. Leong, Koon K. Teo, Sumathy Rangarajan, Patricio Lopez-Jaramillo, Alvaro Avezum Jr, Andres Orlandini, Pamela Seron, Suad H. Ahmed, Annika Rosengren, Roya Kelishadi, Omar Rahman, Sumathi Swaminathan, Romaina Iqbal, Rajeev Gupta, Scott A. Lear, Aytekin Oguz, Khalid Yusoff, Katarzyna Zatonska, Jephat Chifamba, Ehimario Igumbor, Viswanathan Mohan, Ranjit Mohan Anjana, Hongqiu Gu, Wei Li, Salim Yusuf. The Prognostic Importance of Muscle Strength in 139,691 People from 17 Countries: A Prospective Urban Rural Epidemiology (PURE) Study. Lancet. 2015 Jul 18;386(9990):266-73. doi: 10.1016/S0140-6736(14)62000-6. Epub 2015 May 13.
  22. Suchi Grover, Darryl P. Leong, Pey Wen Lou, Dusan Kotasek, Kerry Cheong, Rohit Joshi, Bogda Koczwara, Joseph B. Selvanayagam. Early and late changes in markers of aortic stiffness with breast cancer therapy.Intern Med J. 2015 Feb;45(2):140-7. doi: 10.1111/imj.12645.
  23. Smyth A, Teo KK, Rangarajan S, O'Donnell M, Zhang X, Rana P, Leong DP, Dagenais G, Seron P, Rosengren A, Schutte AE, Lopez-Jaramillo P, Oguz A, Chifamba J, Diaz R, Lear S, Avezum A, Kumar R, Mohan V, Szuba A, Wei L, Yang W, Jian B, McKee M, Yusuf S; PURE Investigators. Alcohol consumption and cardiovascular disease, cancer, injury, admission to hospital, and mortality: a prospective cohort study. Lancet. 2015 Sep 17. pii: S0140-6736(15)00235-4. doi: 10.1016/S0140-6736(15)00235-4. [Epub ahead of print]
  24. Darryl P. Leong, Koon K. Teo, Sumathy Rangarajan, V. Raman Kutty, Fernando Lanas, Chen Hui, Xiang Quanyong, Qian Zhenzhen, Tang Jinhua, Ismail Noorhassim, Khalid F. AlHabib, Sarah J. Moss, Annika Rosengren, Ayse Arzu Akalin, Omar Rahman, Jephat Chifamba, Andrés Orlandini, Rajesh Kumar, Karen Yeates, Rajeev Gupta, Afzalhussein Yusufali, Antonio Dans Álvaro Avezum, Patricio Lopez-Jaramillo, Paul Poirier, Hosein Heidari, Katarzyna Zatonska, Romaina Iqbal, Rasha Khatib, Salim Yusuf. Reference Ranges of Handgrip Strength from 125,462 Healthy Adults in 21 Countries: A Prospective Urban Rural Epidemiologic (PURE) Study. Journal of Cachexia, Sarcopenia and Muscle (In press).
  25. Darryl P. Leong, François Caron, Christopher Hillis, Annie Duan, Jeff S. Healey, Graeme Fraser, Deborah Siegal. The Risk of Atrial Fibrillation with Ibrutinib Use: A Systematic Review and Meta-Analysis. Blood 2016; 128(1): 138-40.

Selected Funding

  • Royal Australasian College of Physicians Astra Zeneca Fellow in Medical Research, 2011
  • Longitudinal mechanics of the peri-infarct zone and ventricular tachycardia inducibility in patients with chronic ischaemic cardiomyopathy. National Health and Medical Research Council and National Heart Foundation of Australia independently co-funded (2010-2014)
  • Reducing the Burden of Stroke Program. Hamilton Health Sciences RFA Research Strategic Initiative Grant (2013-2016)
  • The Detection of Silent Atrial Fibrillation. Michael G. DeGroote Fellowship Award in Clinical Research, 2013
  • PROMISE for Cancer Study. Hamilton Health Sciences New Investigator Fund, 2013-14
  • Role of androgen deprivation therapy in cardiovascular disease - a longitudinal prostate cancer study (RADICAL PC)
  • Cardiovascular and Other Comorbidities in Patients with Cancer (C3). Hamilton Health Sciences RFA Program