Date of release: July 10, 2015
For more information:
of Eastern Ontario
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Embargoed until Friday, July 10, 2015 at 10:00 am EDT
Photos (.jpg format)
- Brian Lichty, associate professor of pathology and molecular medicine, Michael G. DeGroote School of Medicine, McMaster University
- Dr. John Bell, senior scientist at The Ottawa Hospital and professor of medicine and the University of Ottawa
- Dr. David Stojdl, senior scientist at the Children's Hospital of Eastern Ontario and associate professor of the University of Ottawa
- Dr. Derek Jonker, overall lead for the clinical trial, a medical oncologist at The Ottawa Hospital and professor of the University of Ottawa
- Dr. Janet Dancey, NCIC Clinical Trials Group
- Christina Monker, of Rockland, Ont., is one of the first patients treated in a world-first clinical trial of a Canadian viral therapy
Graphics (.jpg format)
A Novel Oncolytic Vaccine in the Fight against Cancer
The Maraba virus used in this trial is a rhabdovirus and has this bullet-like shape. It was discovered in sandflies around the Maraba region of Brazil, and has been engineered to seek out cancer cells and do two things. As an oncolytic virus, it replicates inside the cancer cell and destroys it, while also triggering an immune response that recognizes the cancer as a threat.
The adenovirus used in this trial is an engineered version of the common cold. It has been designed to initialize an immune response to a protein, MAGE-A3, expressed by many solid cancers.
Tumour / virus art from the Stojdl lab
Credit — somersault:1824, David Goodsell and Cronodon