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Research FACILITIES
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DNA Profiling/Gene Expression Profiling Laboratory
McMaster's Gene Expression Profiling Laboratory is a core facility which is presently undergoing expansion and relocation to the Michael G. DeGroote Centre for Learning and Discovery. The expanded facility will comprise wet and dry laboratories in which expression profiling will be used as both a gene discovery tool and as a means to analyse global responses of cells to external stimuli such as candidate drugs.
The facility provides an inter-disciplinary approach to the investigation of Biological, Biochemical, Clinical and Medical areas of research. The facility offers consulting, experimental design, training and technical services for light and electron microscopic imaging, immuno-labeling, image analysis, morphometry, and elemental analysis. It is the largest diagnostic EM Facility in the Canada.
Farncombe Family Gnotobiotic Facility
McMaster is home of Canada's only gnotobiotic, or germ free, research facility for gastrointestinal disease and other research including immunology and microbiology. The $5 million Farncombe Family Gnotobiotic Facility, located at the Health Sciences Centre, was opened in 2005. The 3,000-square-foot laboratory's strict controls ensure sterility and control of the bacterial environment for research into the host-microbial interaction in the gut, a significant issue for understanding immune reactivity in the gut and susceptibility to a range of gastrointestinal and other diseases such as inflammatory bowel and functional bowel diseases, allergy and autoimmunity including diabetes.
The Flow Cytometry Facility, aspects of which are located in the Health Sciences Centre and the Michael G. DeGroote Centre for Learning and Discovery, consist of both research and clinical laboratory facilities. The facility is accessible to a wide spectrum of investigators at McMaster University, as well as outside users. It is operated in a manner that maximizes research user access at a reasonable fee, and provides expertise to aid the users in experimental design and protocol development.
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The new High Content Screening (HSC) Laboratory is currently under construction in McMaster's Health Sciences Centre. In this unique facility, cells will be manipulated either genetically or chemically and assessed rapidly.
High Throughput Screening Laboratory
The High Throughput Screening Laboratoary's Integrated Beckman Robotics System can simultaneously perform more than 300 separate experiments, plus more than 60 controls, in wells no larger than a raindrop. Nearly 100,000 compounds can be investigated in only a few days. The laboratory is one of only a few of its kind in North America. The HTS laboratory is housed in the Health Sciences Centre, in a 1,400-square-foot area that was specifically designed and renovated for the facility.
The Histopathology Lab provides technical and theoretical assistance to researchers in the area of Molecular Immunology, Virology and Inflammation. Faculty, post-doctoral fellows and graduate students make use of the technical expertise and equipment available in the lab. Histological and Immunohistochemistry analysis is provided by trained technicians as required by researchers. The Histopathology Lab is funded by the Centre for Gene Therapeutics, which primarily makes use of its services and facilities.
In the summer of 1992, the School of Rehabilitation Science, in concert with the Faculty of Health Sciences and McMaster University, received a $143,400 grant from the Ministry of Colleges and Universities to develop a facility to educate health care professionals about human movement assessment. The Human Movement Laboratory examines 3D human movement with concentration on pathological, normal and athletic motion. They are able to carry out highly sensitive motion analysis through use of state-of-the-art instrumentation.
The Integrated Microscopy Facility at McMaster University provides an inter-disciplinary approach to the investigation of Biological, Biochemical and Medical areas of research. The experienced staff offers consulting, experimental design, training and technical services for light and electron microscopic imaging, immunolabeling, image analysis, morphometry, freeze fracture and elemental analysis. The facility is the largest diagnostic Electron Microscopy unit in the country.
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The McMaster Regional Centre for Mass Spectometry consist of five mass spectrometers. The facility is operated by a professional manager, a research scientist, a Bio MS specialist and two technologists, who provide mass spectrometric service by analysing approximately 4,000 individual samples per year for many client within the McMaster community and at various external institutions.
MOBIX is a world-class centre for life science and translational research . It provides molecular biology expertise and services to the research community both inside and outside McMaster University. MOBIX consists of a series of centre, each with its own experimental and developmental goals, and all sharing the common vision.
The Nuclear Magnetic Resonance Laboratory is highly regarded in the Canadian chemical community for its versatility in the types of samples as well as the number of nuclei that can be studied by solution and solid state NMR. With seven instruments housed in modern laboratories and valued at approximately $7 million, it is one of the most versatile and best equipped facilities of its kind in Canada. In terms of number of users, it ranks among the top 10 per cent of such facilities in North America.
The Occupational and Environmental Health Laboratory (OEHL) was established in 1979 at McMaster University to provide occupational hygiene services to industry, labour and the general public. The OEHL is a specialized analytical laboratory and their personnel are trained specifically in the analysis and interpretation of samples taken in the workplace and outdoor environments. The laboratory is equipped to analyze fibres, particulates, metals, organics and inorganics.
The BioMedical Prototype Machine Shop specializes in basic prototype work with a straight forward approach, aimed at getting the job done. For the most part the shop is a one person operation, and its current Technical Manager is Vertram Visheau. His duties entail providing technical support to more than 100 faculty members of Health Sciences, plus (to a lesser extent), other universities, hospitals, and biotechnology companies involved in basic and clinical research.
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The Radiochemical Laboratory is an integral part of the McMaster Positron Emission Tomography (PET) Program. Their laboratory is equipped with a negative ion cyclotron (Siemens RDS-112), remotely controlled and automated units for radiochemical synthesis and state-of-the-art analytical equipment for quality control. The laboratory is staffed by two senior Radiochemists, a Radiochemist and one quality control Chemist.
The new Robert E. Fitzhenry Vector Laboratory is the only one of its kind at an academic centre in Canada, and one of a few in North America. The new lab, located in the Michael G. DeGroote Centre for Learning and Discovery, will give McMaster researchers the capacity to ensure the identity, potency, safety and purity of pharmaceutical products, and to produce vectors safe for use in clinical trials.
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