Selected Publications-
Studies on Mitochondrial and
Heat Shock Proteins

  1. Bowes, T. and Gupta, R. S. (2008) Novel mitochondrial extensions provide evidence for a link between microtubule-directed movement and mitochondrial fission. Biochem Biophys Res Commun. 376(1): 40-5. [Abstract]
  2. Gupta, R. S., Ramachandra, N. B., Bowes, T. and Singh, B. (2008) Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10. Novartis Found Symp. 291: 59-68. [Abstract]
  3. Bowes, T., Singh, B. and Gupta, R. S. (2006) Subcellular localization of Fumarase in mammalian cells and tissues. Histochem. Cell Biology. Nov 17 (Epub). [Abstract]
  4. Singh, B. and Gupta, R. S. (2006) Mitochondrial import of human and yeast fumarase in live mammalian cells: Retrograde translocation of the yeast enzyme is mainly caused by its poor targeting sequence. Biochem. Biophys. Res. Commun. 346: 911-918. (CIHR Supported) [Abstract]
  5. Sadacharan, S., Singh, B., Bowes, T. and Gupta, R.S.(2005) Localization of Mitochondrial DNA Encoded Cytochrome c Oxidase Subunits I and II in Rat Pancreatic Zymogen Granules and Pituitary Growth Hormone Granules. Histochem. Cell Biol. Aug 27, 1-13. [Abstract]
  6. Bowes, T.J. and Gupta, R.S. (2005) Induction of mitochondrial fusion by Cysteine-alkylators ethacrynic acid and N-ethylmallimide. J. Cell. Physiol. 202: 796-804. [Abstract]
  7. Gupta, R.S., Bowes, T., Sadacharan, S. and Singh, B. (2005) Intracellular disposition of Mitochondrial Molecular Chaperones (Hsp60, mHsp70, Cpn10 and TRAP-1). In “Extracellular Biology of Molecular Chaperones” B. Henderson and A.G. Pockley (Eds.), Cambridge University Press (in press). [PDF]
  8. Cechetto, J.D., Sadacharan, S.K., Berk, P.D. and Gupta, R. S. (2002) Immunogold localization of mitochondrial aspartate aminotransferase in mitochondria and on the cell surface in normal rat tissues. Histol. Histopathol. 17, 353-364.  [Abstract]
  9. Bowes, T.J. and Gupta, R.S. (2004) Induction of mitochondrial fusion by Cysteine-alkylators ethacrynic acid and N-ethylmallimide. J. Cell. Physiol. 202:796-804.  [Abstract]
  10. Sadacharan, S. K., Cavanagh, A. C. and Gupta, R. S. (2001) Immunoelectron Microscopy Provides Evidence for the Presence of Mitochondrial Heat Shock 10-kDa Protein (Chaperonin 10) in Red Blood Cells and a Variety of Secretory Granules. Histochem. Cell Biol. 116: 507- 517 . [Abstract]
  11. Soltys, B.J., D.W. Andrews, Jemmerson,R. and Gupta, R.S. (2001) Ultrastructural localization of cytochrome c immunoreactivity in secretory granules in normal pancreas and anterior pituitary. Cell Biol. Internat. 25: 331-338. [PDF]
  12. Cechetto, J.D., Soltys, B.J. and Gupta, R S. (2000) Localization of mitochondrial 60-kD heat shock chaperonin (Hsp60) in pituitary growth horomone secretory granules and pancreatic zymogen granules. J. Histochem. Cytochem. 48: 45-56. [Abstract]
  13. Cechetto, J.D. and Gupta, R.S. (2000) Immunoelectron microscopy provides evidence that Tumor necrosis factor receptor-associated protein 1 (TRAP-1) is a mitochondrial protein which also localizes at specific extramitochondrial sites. Exp. Cell Res. 260:30-39. [Abstract]
  14. Soltys, B.J., Kang, D. and Gupta, R.S. (2000) Localization of P32 protein (gC1q-R) in mitochondria and at specific extramitochondrial locations in normal tissues. Histochem. Cell Biol. 114:245-255. [Abstract]
  15. Soltys, B. J. and Gupta, R.S. (2000) Mitochondrial proteins at unexpected Cellular   locations: Export of proteins from mitochondria from an evolutionary perspective .  International Rev. Cytology 194: 133-196. [Abstract] 
  16. Soltys , B. J. and Gupta, R.S. (1999) Mitochondrial proteins at unexpected locations: Are  they exported? Trends Biochem. Sci.  24: 174-177. [Abstract]  [PDF]
  17. Khan, I.U., Wallin, R., Gupta, R.S. and Kammer, G. L. (1998) Protein-kinase A catalyzed phosphorylation of heat shock protein 60 chaperone regualates its attachment to histone 2B in the T lymphocyte plasma membrane. Proc. Natl. Acad. Sci. USA. 95: 10425-10430. [Abstract]
  18. Singh, B., Soltys, B., Wu, Z-C., Patel, H.V., Freeman, K.B. and Gupta, R.S. (1997) Cloning and some novel characteristics of mitochondrial HSP70 from Chinese hamster cells.  Exp. Cell Res. 234: 205-216. [Abstract]
  19. Soltys, B.J. and Gupta, R.S. (1996) Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (hsp60) in mammalian cells.  Experimental Cell Res. 222: 16-27. [Abstract]
  20. Soltys, B.J. and Gupta, R.S. (1996) Cell surface localization of the 60 kDa heat shock chaperonin protein (Hsp60) in mammalian cells. Cell Biololgy International 21: 315-320. [Abstract]
  21. Xu, Q., Schett, G., Seitz, C.S., Hu, Y., Gupta, R.S. and Wick, G. (1994) Surface staining and cytotoxioc activity of heat shock protein 60 antibody on stressed aortic endothelial cells.  Circulation Res.  75: 1078-1085. [Abstract]
  22. Jones, M., Gupta, R.S. and Englesberg, E (1994) Enhancement in amount of P(hsp60) in mutants of Chinese hamster ovary (CHO-K1) cells exhibiting increases in the A-system of amino acid transport.  Proc. Natl. Acad. Sci. USA 91: 858-862. [Abstract]
  23. Bruschi, S.A., West, K.A., Crabb, J.W., Gupta, R.S. and Stevens, J.L. (1993) Mitochondrial HSP60 (P1) and a HSP70-like protein (mortalin) are major targets for modification during S-(1,1,2,2-tetrafluoroethyl)-L-cysteine induced nephrotoxicity.  J. Biol. Chem. 268: 23157-23161. [Abstract]
  24. Kaur, I., Voss, S.D., Gupta, R.S., Schell, K., Fisch, P. and Sondel, P.M. (1993) Human peripheral    T cells recognize HSP60 molecules on Daudi Burkitt's lymphoma cells.  J. Immunol. 150: 2046-2055. [Abstract]
  25. Singh, B. and Gupta, R.S. (1992) Expression of human 60 kDa heat shock proteins (HSP60 or P1) in Escherichia coli and development and characterization of corresponding monoclonal antibodies.  DNA and Cell Biol. 11: 489-496. [Abstract]
  26. Brudzynski, K., Martinez, V. and Gupta, R.S. (1992) Immunocytochemical localization of HSP60 related proteins in beta-cell secretory granules and its altered distribution in non-obese diabetic (NOD) mice.  Diabetologia 35: 316-324. [Abstract]
  27. Viltanen, P.V., Lorimer, G.H., Seetharam, R., Gupta, R.S., Oppenheim, J., Thomas, J.O.  and Cowan, N.J. (1992) Mammalian mitochondrial chaperonin 60 functions as a single toroidal ring.  J. Biol. Chem. 267: 695-698. [Abstract]
  28. Venner, T.J. and Gupta, R.S. (1990) Nucleotide sequence of mouse hsp60 (chaperonin, GroEL homolog) cDNA.  Biochim. Biophys. Acta 1087: 336-338.[Abstract]
  29. Gupta, R.S. (1990).  Microtubule, mitochondria and molecular chaperones: A new model for in vivo assembly of microtubules.  Biochem. Cell Biol. 68: 1352-1363. [Abstract]
  30. Gupta, R.S. (1990).  Sequence and structural homology between a mouse t-complex protein TCP-1 and the 'chaperonin' family of bacterial (GroEL, 60-65 kDa heat shock antigen) and eukaryotic proteins.  Biochem. Int. 20: 833-841. [Abstract]
  31. Gupta, R.S. (1990) Mitochondria, molecular chaperone proteins and the in vivo assembly of microtubules.  Trends in Biochem. Sc. 15: 415-418. [Abstract]
  32. Singh, B., Patel, H.V., Ridley, R.G., Freeman, K.B. and Gupta, R.S. (1990). Mitochondrial import of the human chaperonin protein.  Biochem. Biophys. Res. Commun. 169: 391-396. [Abstract]
  33. Ahmad, S., Ahuja, R., Venner, T. and Gupta, R.S. (1990). Identification of a protein altered in mutants resistant to microtubule inhibitors as a member of the major heat shock protein (hsp70) family.  Mol. Cell Biol. 10: 5160-5165. [Abstract]
  34. Picketts, D.J., Mayanil, C.S.K. and Gupta, R.S. (1989).  Molecular cloning of a Chinese hamster mitochondrial protein related to the "chaperonin" family of bacterial and plant proteins.  J. Biol. Chem. 264: 12001-12008. [Abstract]
  35. Dudani, A.K. and Gupta, R.S. (1989).  Immunological characterization of a human homologue of the 65 kDa mycobacterial antigen.  Infect. & Immun. 57: 2786-2793. [Abstract]
  36. Jindal, S., Dudani, A.K., Singh, B., Harley, C.B. and Gupta, R.S  (1989).  Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65 kDa mycobacterial antigen.  Mol. Cell Biol. 9: 2279-2283. [Abstract]
  37. Gupta, R.S. and Dudani, A.K. (1987).  Mitochondrial binding of a protein affected in mutants resistant to the microtubule inhibitor podophyllotoxin.  Eur. J. Cell Biol. 44: 278-285. [Abstract]
  38. Gupta, R.S. and Austin, R.A. (1987).  Mitochondrial matrix localization of a protein affected in mutants resistant to the microtubule inhibitor podophyllotoxin. Eur. J. Cell Biol. 45: 170-176. [Abstract]
  39. Gupta, R.S. and Gupta, R. (1984).  Mutants of Chinese hamster ovary cells affected in two different microtubule associated proteins: Genetic and biochemical studies.  J. Biol. Chem. 259: 1882-1890. [Abstract]
  40. Gupta, R.S., Ho, T.K.W., Moffat, M.R.K. and Gupta, R. (1982). Podophyllotoxin-resistant mutants of Chinese hamster ovary cells.  Alteration in a microtubule-associated protein.  J. Biol. Chem. 257: 1071-1078. [Abstract]



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