Selected Publications-
Biochemical and Structure-Function Studies on Adenosine Kinase

  1. Cui, X. A., Agarwal, T., Singh, B. and Gupta, R. S. (2011) Molecular characterization of chinese hamster cells mutants affected in adenosine kinase and showing novel genetic and biochemical characteristics. BMC Biochem. 12(1): 22. [Abstract]
  2. Cui, X. A., Singh, B., Park, J. and Gupta, R. S. (2009) Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus. Biochem Biophys Res Commun. 388(1): 46-50. [Abstract]
  3. Park, J., Singh, B. and Gupta, R. S. (2009) Mycobacterial adenosine kinase is not a typical adenosine kinase. FEBS Lett. 583(13):2231-6. [Abstract]
  4. Park, J. and Gupta, R. S. (2008) Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci. 65(18): 2875-96. [Abstract]
  5. Park, J., van Koeverden, P., Singh, B. and Gupta, R. S. (2007) Identification and characterization of human ribokinase and comparison of its properties with E. coli ribokinase and human adenosine kinase. FEBS Lett. 581(17): 3211-6. [Abstract]
  6. Park, J., Vaidyanathan, G., Singh, B. and Gupta, R.S. (2007) Identification and biochemical studies on novel non-nucleoside inhibitors of the enzyme adenosine kinase. The Protein Journal. Jan 5 [Epub]. [Abstract]
  7. Park, J., Singh, B. and Gupta, R. S. (2006) Inhibition of adenosine kinase by phosphonate and bisphosphonate derivatives. Mol. Cell. Biochem. 283: 11-21. [Abstract]
  8. Singh , B. and Gupta, R. S. (2004) Genomic Organization and Linkage via a Bidirectional Promoter of the Adaptor Protein Complex-3 (AP-3) μ3A  and  Adenosine Kinase (AK) Genes: Deletion Mutants of AK in Chinese Hamster Cells Extends into the AP-3 μ3A Gene. Biochemical Journal 378: 519-528. [Abstract]
  9. Park, J., Singh, B., Maj, M. and Gupta, R. S. (2004) Phosphorylated Derivatives that Activate or Inhibit Mammalian Adenosine Kinase (AK) Provide    Insights into the Role of Pentavalent Ions in AK Catalysis. J. Protein Chemistry 23: 167-177. [Abstract]
  10. Maj, M.C., Singh, B. and Gupta, R. S. (2002) Pentavalent ions dependency is a conserved property of adenosine kinase from diverse sources: Identification of a novel motif implicated in phosphate and magnesium ion binding and substrate inhibition. Biochemistry, 41: 4059-69. [Abstract]
  11. Singh, B., Lin, A., Wu,  Z.C. and Gupta,R.S. (2001) Gene structure for adenosine kinase in Chinese hamster and human : high-frequency mutants of CHO cells involve deletions of several introns and exons. DNA and Cell Biol. 20: 53-65. [Abstract]
  12. Maj, M. and Gupta, R.S. (2001) The effect of inorganic phosphate on the activity of bacterial Ribokinase. J. Prot. Chem 20: 139-144. [Abstract]
  13. Maj, M., Singh, B. and Gupta, R.S. (2000) Structure-Activity Studies on Mammalian Adenosine Kinase. Biochem. Biophys. Res. Commun. 275:386-393.  [Abstract]
  14. M. Maj, B. Singh and Gupta, R.S. (2000) The influence of inorganic phosphate on the activity of adenosine kinase. Biochem. Biophys. Acta. 1476: 33-42. [Abstract]
  15. Hao, W. and Gupta, R.S. (1996) Pentavalent ion dependency of mammalian adenosine kinase.  Biochem. Mol. Biol. International 38: 889-899. [Abstract]
  16. Gupta, R.S. (1996) Adenosine-AMP exchange activity is an integral part of the mammalian adenosine kinase.  Biochem. Mol. Biol. Internat. 39: 493-502. [Abstract]
  17. Singh, B., Hao, W., Wu, Z-C., Eigle, B. and Gupta, R.S. (1996) Cloning and characterization of cDNA fro adenosine kinase from mammalian (Chinese hamster, mouse, human and rat) species: High frequency mutants of Chinese hamster ovary cells involve structural alterations in the gene.  E.J. Biochem. 241: 564-571. [Abstract]
  18. Gupta, R.S. (1989) Purine  nucleoside analogs. In "Drug Resistance in Mammalian Cells"  Vol. I, Gupta, R.S. (ed.) CRC Press, pp. 89-110.
  19. Gupta, R.S. and Mehta, K.D. (1986).  Genetic and biochemical characteristics of three different types of mutants of mammalian cells affected in adenosine kinase.  In Purine Metabolism in Man V.  (W.L. Nyhan, ed.)., Plenum Press, 595-604.
  20. Mehta, K.D. and Gupta, R.S. (1986).  Novel mutants of CHO cells resistant to adenosine analogs and containing biochemically altered form of adenosine kinase in cell extracts.  Som. Cell. & Mol. Genet. 12: 21-31. [Abstract]
  21. Mehta, K.D. and Gupta, R.S. (1985).  Chinese hamster ovary cells mutants specifically affected in the phosphorylation of C-purine nucleosides.  Can. J. Biochem. Cell. Biol. 63: 1044-1048. [Abstract]
  22. Mehta, K.D. and Gupta, R.S. (1983).  Formycin B-resistant mutants of Chinese hamster ovary cells: Novel genetic and biochemical phenotype affecting adenosine kinase.  Mol. Cell. Biol. 3: 1468-1477. [Abstract]
  23. Gupta, R.S., and Siminovitch, K.L. (1978).  Genetic and biochemicalstudies with the adenosine analogs toyocamycin and tubercidin: Mutation at the adenosine kinase locus in Chinese hamster cells.  Somat. Cell Genet. 4: 715-736. [Abstract]



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