Firestone Research
St. Joseph's Healthcare
50 Charlton Avenue East
Hamilton, Ontario
Canada L8N 4A6
905.522.1155 x33140
Call: 900-522-1155 x32722 or E-Mail: PURR at FIRH
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Research studies conducted by FIRH at St. Joseph's Healthcare Hamilton must be approved by the hospital's independent Research Ethics Board (REB). The following is a list of some of the approved and ongoing studies. The official list is maintained by the REB. As well, registered clinical trial can be accessed through Clinical Trials Registeries. To access an independent site under the direction of the National Institues of Health CLICK HERE
Project Number |
Project Name |
Primary Investigator |
Co-Investigators |
|
11-3500 |
The effects of epithelial-derived thymic stromal lymphopoietin on cord blood CD34+ cell eosinophil/basophil lineage commitment |
Dr. Helen Neighbour, Dr. Mark Larche |
Dr. Judah Denburg |
|
11-3499 |
Relationship between nasal, sputum and blood eosinophils levels, sinus computed tomography scans and fungal allergy in patients with asthma |
Dr. Helen Neighbour, Ms. Anushya Chelvanathan |
|
|
11-3461 |
A compassionate use open-label study of anti IL-5 (mepolizumab) treatment in subjects with hypereosinophilic syndrome |
Dr. Parameswaran Nair |
|
|
10-3455 |
Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC): Development of a standardized nasal allergen challenge model for a multi-center research collaborative to investigate novel therapeutic agents for allergic rhinitis. |
Dr. Helen Neighbour |
Dr. Anne Ellis, Dr. Paul Keith, Dr. Susan Waserman, Dr. Louis-Philippe Boulet |
|
10-3426 |
Pulmonary Research Registry at FIRH |
Dr. Martin Kolb |
|
|
10-3443 |
A comparison of 2 methods to process nasal lavage fluid for differential cell counts |
Dr. Helen Neighbour |
|
|
10-3385 |
Assessing miRNA expression in LPS-stimulated sputum-derived macrophages from smokers and COPD patients |
Dr. Parameswaran Nair, Mr. Jake Nikota |
Dr. Martin Stampfli |
|
10-3384 |
Airway and blood whole-genome gene expression analysis in patients with prednisone-dependent asthma and eosinophilic bronchitis |
Dr. Parameswaran Nair |
Dr. Benjamin Raby, Dr. Frederick Hargreave, Ms. Shannon Riley |
|
08-3085 |
The effects of human adipocytes on airway smooth muscle function |
Dr. Parameswaran Nair, Ms. Amanda Giesler |
Dr. Shannon Trainor |
|
10-3363 |
Sinus surgery and nasal polypectomy in patients with severe prednisone-dependent asthma is a steroid sparing intervention by reducing IL-5 production in the nose |
Dr. Helen Neighbour, Dr. Julie Strychowsky |
Dr. Parameswaran Nair, Dr. Doron Sommer, Dr. Elizabeth Jeney |
|
10-3391 |
A pilot, observational study to establish the feasibility of utilizing the Blackberry handheld system to monitor disease activity to determine the natural progression of Idiopathic Pulmonary Fibrosis |
Dr. Martin Kolb |
|
|
10-3336 |
A phase II open label, roll over study of the long term tolerability, safety and efficacy of oral BIBF 1120 in patients with idiopathic pulmonary fibrosis |
Dr. Martin Kolb |
Dr. Gerard (P.G.) Cox |
|
10-3341 |
A randomized, double-blind, placebo-controlled, parallel group study to compare GW766994 (an oral CCR3 receptor antagonist) versus placebo in patients with asthma and sputum eosinophilia |
Dr. Parameswaran Nair |
Dr. Frederick Hargreave, Dr. Paul O'Byrne, Dr. James Martin, Dr. C. Lemiere, Dr. Louis-Philippe Boulet |
|
10-3340 |
Difficult asthma program: patients with refractory asthma |
Dr. Parameswaran Nair |
Dr. James Martin, Dr. Qutayba Hamid, Dr. Pierre Ernst |
|
10-3339 |
Mediation of allergic airway inflammation and pathology by Oncostatin M. |
Dr. Parameswaran Nair |
Dr. Carl Richards |
|
10-3365 |
Quality management of chronic obstructive lung disease in primary care practice in the Hamilton-Wentworth region. A pilot study |
Dr. Andrew McIvor |
|
|
10-3335 |
A randomized, active-controlled, double-blind, double-dummy, parallel group design, multi-center trial to compare the efficacy and safety of 2.5 mcg and 5 mcg tiotropium inhalation solution delivered by the Respimat inhaler with tiotropium inhalation caps |
Dr. Gerard (P.G.) Cox |
Dr. Martin Kolb |
|
10-3322 |
Effect of allergen challenge on inflammation induced by toll-like receptor stimulation in a nasal model |
Dr. Helen Neighbour |
Dr. Parameswaran Nair, Dr. Mark Larche |
|
10-3304 |
TNF-alpha antagonists for acute exacerbations of COPD: A randomized, double-blind, placebo-controlled pilot trial |
Dr. Parameswaran Nair, Dr. Shawn Aaron |
Dr. Francois Maltais, Dr. Jean Bourbeau, Dr. Mark Fitz Gerald, Dr. Stephen Fields, Dr. Darcy Marciniuk, Dr. David C. Todd |
|
10-3308 |
Characteristics of patients with high levels of sputum macrophages |
Dr. Helen Neighbour |
|
|
09-3278 |
Randomized, double-blind, placebo-controlled, 3-way cross-over study to determine the effect of 6 weeks treatment of orally inhaled BI 1744 CL (5µg [actuations of 2.5 µg] and 10 µg [2 actuations of 5 µg]) delivered by the Respimat® inhaler on exercise end |
Dr. Andrew McIvor |
Dr. Gerard (P.G.) Cox, Dr. David C. Todd |
|
09-3242 |
Imaging of idiopathic pulmonary fibrosis with 18F-proline and PET pilot study |
Dr. Martin Kolb, Dr. Renee Labiris |
Dr. Karen Gulenchyn, Dr. Gerard (P.G.) Cox |
|
09-3272 |
Burden of illness in patients with moderate and severe chronic obstructive pulmonary disease in Canada: chart review and patient survey |
Dr. Gerard (P.G.) Cox |
|
|
09-3204 |
Double-blind, crossover, placebo-controlled evaluation of the effect of PUR003 on allergen-induced airway inflammation in subjects with atopic asthma |
Dr. Parameswaran Nair |
Dr. John Hanrahan, Dr. Frederick Hargreave |
|
09-3232 |
Repeat dose nasal allergen challenge: development of a model to investigate the cellular and inflammatory changes that occur in allergic rhinitis |
Dr. Helen Neighbour |
Dr. Mark Larche, Dr. Parameswaran Nair |
|
09-3231 |
A dose-ranging study of the effects of SCH 527123 in subjects with moderate to severe COPD |
Dr. Andrew McIvor |
Dr. Gerard (P.G.) Cox |
|
09-3251 |
A pilot study of protein biomarker discovery and validation in sputum in asthma |
Dr. Parameswaran Nair |
Dr. Frederick Hargreave, Dr. William Calhoun |
|
09-3252 |
A pilot study of microRNA discovery and validation in sputum in asthma |
Dr. Parameswaran Nair |
Dr. Frederick Hargreave, Dr. Paul Foster, Dr. N. Hansboro |
|
09-3170 |
ARTEMIS: A Phase 3, randomized, double-blind, placebo-controlled, multi-center, parallel-group, event-driven study to evaluate the efficacy and safety of ambrisentan in subjects with early idiopathic pulmonary fibrosis |
Dr. Gerard (P.G.) Cox |
Dr. Martin Kolb |
|
09-3145 |
The efficacy of orally administered GSK2190915 as an add-on to current therapy in subjects with moderate to severe asthma who have elevated sputum neutrophils |
Dr. Parameswaran Nair |
Dr. Paul O'Byrne |
|
09-3167 |
MUSIC - Macitentan use in an idiopathic pulmonary fibrosis clinical study - a double-blind, randomized, placebo-controlled, multicenter, parallel group study to evaluate the efficacy, safety, and tolerability of macitentan in patients with idiopathic pulm |
Dr. Gerard (P.G.) Cox |
Dr. Martin Kolb |
|
08-3105 |
Systemic effects of COPD (Chronic Obstructive Pulmonary Disease) |
Dr. Andrew McIvor |
Dr. David C. Todd, Dr. Renee Labiris |
|
09-3144 |
Neutrophils in severe asthma |
Dr. Parameswaran Nair, Ms. Afia Aziz-ur-Rehman |
Dr. Frederick Hargreave, Dr. Mark Larche |
|
08-3128 |
A pragmatic, randomized, controlled study evaluating the impact of access to smoking cessation treatment reimbursement on the proportion of successful quitters in a Canadian population of smokers motivated to quit |
Dr. Andrew McIvor |
|
|
08-3127 |
Validating a Method of Ascertaining Disease in Population-Based Longitudinal Research |
Dr. Malcolm Sears, Dr. Mark Oremus |
Dr. Ron Postuma, Dr. Cynthia Balion, Dr. Frederick Burge |
|
08-3106 |
A Phase 2, multicenter, multinational, randomized, double-blind, placebo-controlled, parallel group, dose-ranging study evaluating the efficacy and safety of CNTO 888 administered intravenously in subjects with idiopathic pulmonary fibrosis |
Dr. Martin Kolb |
Dr. Gerard (P.G.) Cox |
|
08-3049 |
Open-label extension study in patients with idiopathic pulmonary fibrosis who completed protocol AC-052-321/BUILD 3 |
Dr. Gerard (P.G.) Cox |
Dr. Martin Kolb |
|
08-2965 |
Sputum and methachloline database |
Dr. Parameswaran Nair |
Dr. Frederick Hargreave, Dr. John Brannan, Dr. Liesel D'Silva, Dr. Nesreen Hassan |
|
08-3037 |
Gene expression analysis in sputum and blood of patients with asthma: a feasibility study |
Dr. Parameswaran Nair, Dr. Geoffrey Chupp |
|
|
08-3034 |
Signed consents for contact for future studies |
Dr. Andrew McIvor |
|
|
08-2987 |
An open-label phase followed by a randomized, double-blind, placebo-controlled phase in a study designed to evaluate intravenous 2-0, 3-0 desulfated heparin (ODSH) in hospitalized subjects with exacerbations of chronic obstructive pulmonary disease |
Dr. Andrew McIvor |
Dr. Jill Rudkowski |
|
08-3018 |
A prospective validation of persistent sputum neutrophilia for the detection of bronchiectais |
Dr. Parameswaran Nair |
Dr. Nicole Drost, Dr. Ryan Rebello |
|
08-2984 |
A prospective, multinational, multicenter, randomized, double-blind, double-dummy, controlled study comparing the efficacy and safety of moxifloxacin to that of amoxicillin-clavulanic acid for the treatment of subjects with acute exacerbations of chronic |
Dr. Andrew McIvor |
|
|
08-2995 |
The effect of exacerbations on the function and structure of epithelial cell cilia in chronic obstructive pulmonary disease |
Prof. Myrna Dolovich, Dr. Parameswaran Nair |
Dr. Asma Yaghi |
|
08-2976 |
Safety of SCH 527123 in subjects with neutrophilic asthma |
Dr. Parameswaran Nair |
|
|
08-2971 |
A 24-week (+ 24 week extension), randomised, placebo-controlled (only 1st 12-week period), double-blind, parallel-group, efficacy and safety comparison of tiotropium/salmeterol (7.5 ug/25) inhalation powder in the morning (PE capsule via tiotropium/salmet |
Dr. Andrew McIvor |
Dr. David C. Todd |
|
08-2964 |
Cross-sectional screening of ragweed allergic, house dust mite allergic and grass allergic subjects for T cell responses and basophil histamine release to allergen-derived MHC-characterised T cell peptide epitopes |
Dr. Parameswaran Nair, Dr. Mark Larche |
|
|
07-2940 |
An efficacy and safety study of reslizumab (CTX55700) in the treatment of poorly controlled asthma in subjects with eosinophilic airway inflammation |
Dr. Parameswaran Nair |
|
|
07-2917 |
Should non-eosinophilic asthmatic subjects be treated with inhaled corticosteroids? |
Dr. Parameswaran Nair, Dr. C. Lemiere |
|
|
07-2865 |
Prednisone dependant asthma audit |
Dr. Parameswaran Nair |
|
|
07-2929 |
The Canadian healthy infant longitudinal development (CHILD) study |
Dr. Malcolm Sears |
Dr. Padmaja Subbarao, Dr. Allan Becker, Dr. Piush Mandhane |
|
07-2926 |
Usage pattern of sputum cell counts among specialists in Canada |
Dr. Frederick Hargreave, Dr. Parameswaran Nair |
Dr. Liesel D'Silva |
|
07-2927 |
Heterogeneity of bronchitis in airway diseases in a university outpatient clinic |
Dr. Parameswaran Nair |
|
|
06-2777 |
Quality management of chronic obstructive lung disease in primary care practice in the Hamilton-Wentworth region. A pilot study (terminated) |
Dr. Andrew McIvor |
|
|
07-2860 |
A multicentre, randomized, double-blind, placebo, and active-controlled, 6-week study to evaluate the safety, tolerability and pharmacodynamic activity of inhaled TPI 1020 in COPD subjects |
Dr. Parameswaran Nair, Dr. Francois Maltais |
Dr. Julie Milot, Dr. Jean Bourbeau, Dr. Stewart Pugsley |
|
07-2814 |
The efficacy of orally administered zileuton, A 5-lipooxygenase (5-LO) inhibitor, in addition to current therapy in subjects with moderate to severe asthma who have elevated sputum neutrophils - a feasibility study |
Dr. Parameswaran Nair |
Dr. Frederick Hargreave, Dr. Paul O'Byrne, Dr. John Brannan, Dr. Liesel D'Silva, Dr. Sally Wenzel |
|
07-2837 |
Do myofibroblasts play a role in fixed airflow obstruction in asthmatics? |
Dr. Martin Kolb |
Dr. Paul O'Byrne, Dr. Helen Neighbour |
|
07-2859 |
The effect of allergen-provocation on airway responses in patients with asthma treated with bronchial thermoplasty |
Dr. Parameswaran Nair |
Dr. Naomi Spitale, Dr. Frederick Hargreave, Dr. Gerard (P.G.) Cox, Dr. John D. Miller |
|
07-2854 |
A randomized, double-blind, placebo-controlled two-year trial to examine the changes in exercise endurance and COPD patients treated with Tiotropium (Spiriva® HandiHalerTM) 18µg once daily (EXACTT trial) |
Dr. Andrew McIvor |
Dr. David C. Todd |
|
07-2858 |
Prospective evaluation of quantitative cell analysis from tracheal aspirates in patients with chronic airflow limitation |
Dr. Parameswaran Nair, Dr. Nicole Drost |
Dr. Frederick Hargreave, Dr. Mark Soth, Dr. Deborah Cook, Dr. Roman Jaeschke |
|
07-2862 |
A 12 month, double blind, randomized, placebo-controlled trial evaluating the effect of BIBF 1120 administered at oral doses of 50 mg qd, 50 mg bid, 100 mg bid and 150 mg bid on forced vital capacity decline during one year, in patients with idiopathic pu |
Dr. Martin Kolb, Dr. Gerard (P.G.) Cox |
Dr. Antje Ask |
|
07-2864 |
Study of cycles of respiratory symptoms and their relation to respiratory viral infections and other factors in subjects with chronic obstructive lung disease |
Mr. Neil Johnston |
Dr. Andrew McIvor |
|
07-2833 |
A 12-week, double-blind, randomized, parallel group, multi-centre, study to evaluate efficacy and safety of budesonide/formoterol (Symbicort® Turbuahaler®) 320/9 ug one inhalation twice daily on top of tiotropium (Spiriva®) 18 ug one inhalation once daily |
Dr. Andrew McIvor |
|
|
06-2755 |
Roche integrin antagonist follow-up for undetected progressive multifocal leukoencephalopathy (PML) |
Dr. Frederick Hargreave |
|
|
06-2750 |
The effect of dietary supplementation with encapsulated fish oil on mannitol-induced airway sensitivity and inflammation in persons with asthma |
Dr. Paul O'Byrne |
Dr. John Brannan, Dr. Parameswaran Nair |
|
07-2850 |
Airway inflammation and treatment characteristics associated with breakthrough brochoconstriction to hypertonic saline during sputum induction |
Dr. Parameswaran Nair |
Dr. Liesel D'Silva |
|
07-2832 |
Retrieval of human airway tissue and culturing of human airway cells |
Prof. Myrna Dolovich, Dr. Asma Yaghi |
Dr. David McCormack, Dr. Richard Inculet |
|
06-2782 |
Effects of bosentan on morbidity and mortality in patients with Idiopathic Pulmonary Fibrosis - a multicenter, double-blind, randomized, placebo-controlled, parallel groups, event-driven, group sequential, phase III study |
Dr. Gerard (P.G.) Cox |
Dr. Martin Kolb |
|
06-2784 |
A phase II, randomized, double-blind, placebo-controlled, parallel-groups, multicenter study to evaluate and compare the safety, tolerability and efficacy of two dosages of inhaled TIP ASM8 (0.25 mg and 0.5mg) with placebo administered for 14 days in adul |
Dr. Parameswaran Nair |
Dr. Frederick Hargreave |
|
07-2789 |
The impact of air pollution on airway inflammation in the City of Hamilton, Canada |
Dr. Parameswaran Nair |
Dr. Liesel D'Silva, Dr. Pavlos S. Kanaroglou, Dr. Julie Wallace |
|
06-2754 |
Measurement of exhaled breath condensate pH following Bernstein test in subjects with and without reflux cough |
Dr. Parameswaran Nair |
Dr. Annees Sindi, Dr. Christopher Allen, Ms. Susan Armstrong |
|
06-2764 |
Long term safety evaluation of bronchial thermoplasty with the alair system in patients with severe asthma |
Dr. Gerard (P.G.) Cox, Dr. John D. Miller |
Dr. Parameswaran Nair |
|
06-2723 |
A study of the etiology of cyclic epidemics of COPD exacerbations |
Dr. Andrew McIvor, Mr. Neil Johnston |
Dr. Marek Smieja, Dr. Tim Higenbottam, Dr. Sebastian Johnston |
|
06-2696 |
Ciliary function in COPD: relation to the severity of disease |
Prof. Myrna Dolovich, Dr. Gerard (P.G.) Cox |
Dr. Asma Yaghi |
|
06-2671 |
A prospective one year study on the causes, characteristics, mechanisms and kinetics of infective exacerbations in subjects with asthma |
Dr. Parameswaran Nair, Dr. Frederick Hargreave |
Dr. James Mahony, Dr. Liesel D'Silva |
|
06-2664 |
The changing pattern of airway inflammation during subsequent exacerbations of airways disease in an individual patient |
Dr. Parameswaran Nair |
|
|
06-2665 |
The masking effect of sputum neutrophilia during an infective exacerbation of airways disease |
Dr. Parameswaran Nair |
|
|
06-2634 |
Determining the optimal timing of measurements to investigate the influence of sex hormones on airway inflammation |
Dr. Malcolm Sears |
Dr. Piush Mandhane, Dr. Mark Inman |
|
06-2646 |
Effect of roflumilast in COPD patients treated with salmeterol. A 24-week, double-blind study with 500 µg roflumilast once daily versus placebo (The EOS-Study) |
Dr. Andrew McIvor |
Dr. David C. Todd |
|
06-2644 |
Cost and utility analysis of using sputum cell counts in asthma management |
Dr. Parameswaran Nair |
Dr. Frederick Hargreave, Dr. Liesel D'Silva |
|
06-2606 |
Effect of roflumilast on exacerbation rate in patients with COPD. A 52-week, double-blind study with 500 mcg roflumilast once daily versus placebo (the HERMES study). |
Dr. Andrew McIvor |
Dr. Gerard (P.G.) Cox |
|
05-2573 |
Fibroblast progenitors in the circulation of patients with acute and chronic lung injury |
Dr. Martin Kolb |
Dr. Gerard (P.G.) Cox |
|
05-2522 |
Safety and effectiveness of the Alair system for the treatment of asthma: a multicenter randomized clinical trial (Asthma Intervention Research (AIR) II Trial) |
Dr. Gerard (P.G.) Cox, Dr. John D. Miller |
Dr. Parameswaran Nair |
|
05-2543 |
Double-blind, Crossover Placebo-controlled Evaluation of the Effect of Levalbuterol (R-albuterol) on Allergen-Induced Airway Inflammation in Subjects with Atopic Asthma |
Dr. Parameswaran Nair |
Dr. Paul O'Byrne, Dr. Liesel D'Silva |
|
05-2557 |
Asthma in obese subjects - Diagnostic and therapeutic strategies |
Dr. Andrew McIvor, Dr. Shawn Aaron, Dr. Gerard (P.G.) Cox |
|
|
05-2453 |
How airway remodeling and hyperresponsiveness contribute to airflow obstruction in asthma |
Dr. Gerard (P.G.) Cox |
Dr. Mark Inman |
|
05-2450 |
In situ detection of lung inflammation in COPD using 18 fluorodexyglucose and positron emission tomography (PET) |
Prof. Myrna Dolovich, Dr. Renee Labiris, Dr. Gerard (P.G.) Cox |
Dr. Karen Gulenchyn, Dr. David C. Todd, Dr. Parameswaran Nair |
|
05-2473 |
Emergency Department asthma care project (EDACP) - A pilot study |
Dr. Malcolm Sears |
|
|
05-2472 |
Extension study for the multicenter randomized clinical trial of the Alair System for the bronchial thermoplasty treatment of asthma |
Dr. Gerard (P.G.) Cox |
Dr. Parameswaran Nair |
|
05-2440 |
Randomized Placebo-controlled Trial of Montelukast in Modulating Exacerbations of Asthma in Children, September 2005 |
Dr. Malcolm Sears |
Mr. Neil Johnston, Dr. Piush Mandhane, Dr. Madan Roy, Dr. Susan Waserman, Dr. Paul Keith, Dr. L.N. Whitehead |
|
04-2407 |
The role of human airway smooth muscle in eosinophil differentiation and migration |
Dr. Parameswaran Nair, Dr. Roma Sehmi |
Mr. Adrian Fanat |
|
04-2345 |
A comparison of symbicort® single inhaler therapy (symbicort® 200 turbuhaler® 1 inhalation b.i.d. plus as needed) and conventional best practice for the treatment of persistent asthma in adolescents and adults - a 26-week, randomized, open-label, parallel |
Dr. Malcolm Sears |
Dr. Parameswaran Nair |
|
04-2356 |
Determining the optimal timing of measurements to investigate the influence of sex hormones on airway inflammation (continued under 06-2634) |
Dr. Malcolm Sears |
Dr. Piush Mandhane, Dr. Mark Inman |
|
04-2357 |
Sex differences in the epidemiology of asthma and atopy: the role of hormones |
Dr. Malcolm Sears |
Dr. Piush Mandhane, Dr. Mark Inman |
|
04-2346 |
Randomized placebo-controlled trial of montelukast in lodulating the September epidemic of exacerbations of asthma in children |
Dr. Malcolm Sears |
Mr. Neil Johnston, Dr. Piush Mandhane, Dr. Madan Roy, Dr. Susan Waserman, Dr. Paul Keith |
|
04-2347 |
Determining the most valid, reliable, and feasible method of measuring sex hormones in an outpatient population |
Dr. Malcolm Sears |
Dr. Piush Mandhane, Dr. Mark Inman, Dr. Jack Rosenfeld |
|
03-2281 |
#0903-27 Multi-center Randomized Clinical Trial of Bronchial Thermplasty with the Alair System for the Treatment of Severe Asthma. |
Dr. Gerard (P.G.) Cox, Dr. John D. Miller |
Dr. Parameswaran Nair |
|
03-2275 |
Do sex hormones modulate atopy or airway inflammation in asthma and explain the higher incidence of female asthma in puberty and increased severity of adult female asthma? |
Dr. Malcolm Sears |
Dr. Mark Inman, Dr. Piush Mandhane |
|
03-2262 |
Automating the processing of sputum for cell counts: Testing the accuracy of a new and innovative device. |
Dr. Frederick Hargreave |
Dr. Emilio Pizzichini, Dr. Marcia Pizzichini, Dr. Ann Efthimiadis |
|
03-2217 |
The effect of diurnal variation on nasal ciliary beat frequency. |
Prof. Myrna Dolovich |
Dr. Renee Labiris |
|
03-2209 |
A 13 week randomised, double-blind, parallel group, multicentre study to compare the bronchial anti-inflammatory activity of oral Cilomilast (15 mg bd) with placebo twice daily in subjects with chronic obstructive pulmonary disease (COPD) |
Dr. Frederick Hargreave |
Dr. Emilio Pizzichini, Dr. Richard Leigh, Dr. John D. Miller |
|
02-2182 |
How Smoking Causes COPD: Examination of Immune System Changes |
Dr. Gerard (P.G.) Cox |
Dr. Martin Stampfli, Dr. Andrew McIvor |
|
03-2195 |
Diary of asthma and viral infection study (DAVIS) |
Mr. Neil Johnston, Dr. Malcolm Sears |
Dr. Susan Waserman, Dr. Paul Keith, Dr. Madan Roy, Dr. Sebastian Johnston |
|
02-2159 |
Is use of inhaled Ipratropium Bromide associated with increased risk of death in patients with Chronic Obstructive Pulmonary Disease (COPD) with and without Co-morbidity? |
Dr. Malcolm Sears |
Dr. Mohammed Alanezi, Dr. Stewart Pugsley |
|
02-2142 |
International study of asthma and allergies in childhood (ISAAC) in Canada (Phase Three) |
Dr. Malcolm Sears |
Dr. Marcia Pizzichini |
|
02-2132 |
Respiratory Disease Related to Metal Working Fluid Exposure |
Dr. Frederick Hargreave |
Dr. John Oudyk, Dr. Ted Haines, Dr. David Muir |
|
02-2150 |
Dose-ranging study of Ro-27-2441 in patients with persistent asthma not treated with inhaled corticosteroids - Phase II |
Dr. Frederick Hargreave |
Dr. Emilio Pizzichini, Dr. Mylinh Duong |
|
02-2156 |
A randomised, double-blind, double-dummy, placebo-and active-controlled, parallel group efficacy and safety comparison of 12-week treatment of two doses … of Tiotropium inhalation solution delivered by the Respimat inhaler, placebo and Ipratropium Brommid |
Dr. Frederick Hargreave |
Dr. Emilio Pizzichini |
|
02-2130 |
A single-centre, longitudinal study to explore inflammatory markers in the spontaneous and induced sputum of patients with chronic bronchitis |
Dr. Frederick Hargreave |
Dr. Marcia Pizzichini |
|
02-2129 |
A single-centre, longitudinal study to explore inflammatory markers in the induced sputum of patients with asthma |
Dr. Frederick Hargreave |
Dr. Marcia Pizzichini |
|
02-2143 |
Development of a method for processing sputum obtained from subjects with Cystic Fibrosis |
Dr. Gerard (P.G.) Cox |
Dr. Andreas Freitag, Dr. Margaret Kelly |
|
02-2104 |
Multi-center randomized clinical trial of the Alair (TM) System for the bronchial thermoplasty treatment of asthma |
Dr. Gerard (P.G.) Cox |
Dr. John D. Miller |
|
02-2115 |
The Effects of a Humanized Anti-IL-5 Monoclonal Antibody (SB-240563) on Asthma Control and Airway Eosinophilia in Asthmatic Subjects |
Dr. Frederick Hargreave |
Dr. Paul O'Byrne, Dr. Mark Inman, Dr. C. Lemiere, Dr. A. Cartier, Dr. Parameswaran Nair |
|
02-2116 |
An Assessment of the Anti-inflammatory Properties of Low Dose Inhaled Ciclesonide in Asthmatic Patients |
Dr. Frederick Hargreave |
Dr. Andrew Wilson, Prof. Myrna Dolovich, Dr. Paul O'Byrne |
|
02-2101 |
Effect on Lung Ventilation of HFA-Beclomethasone Dipropionate (QVAR) and HFA-Fluticasone Diproionate (FP) Therapy in Asthma Measured by PET |
Prof. Myrna Dolovich |
Dr. Frederick Hargreave, Dr. Andrew Wilson, Dr. Geoffrey Coates, Dr. Karen Gulenchyn |
|
02-2074 |
A Comparison of Treatment with 250 microgram Roflumilast versus 500 micrograms Roflumilast versus Placebo over 24 Weeks in Patients with Chronic Obstructive Pulmonary Disease (COPD) |
Dr. Frederick Hargreave |
Dr. Marcia Pizzichini, Dr. Emilio Pizzichini |
|
02-2095 |
Lung Function and X-rays in Young Adult Smokers and Non-smokers |
Dr. Malcolm Sears |
Dr. Gerard (P.G.) Cox, Dr. Robin Taylor, Dr. Julian Dobranowski |
|
02-2052 |
A Double-blind, Placebo-Controlled, Parallel Group Study of Uridine 5' - Triphosphate (UTP) Solution for Inhalation as an Adjunct in the Diagnosis of Lung Cancer by Sputum Cytology |
Dr. Gerard (P.G.) Cox |
|
|
02-2075 |
Blown Nasal secretion measurements in rhinosinusitis: repeatability and validity compared to nasal lavage |
Dr. Frederick Hargreave |
Dr. Mylinh Duong, Dr. Parameswaran Nair |
|
02-2073 |
Spiriva Assessment of FEV1. (SAFE). The Effect of Inhaled Tiotropium Bromide (18 mcg once daily) on the Change in FEV1 During Long-term Treatment in Patient with COPD. A One-year Parallel Group, Double-blind, Randomized, Placebo-controlled Study |
Dr. Frederick Hargreave |
|
|
01-1973 |
The examination of neutrophil responses in subjects with steroid-resistant asthma. |
Dr. Gerard (P.G.) Cox |
Dr. Frederick Hargreave |
|
02-2035 |
Spiriva Assessment of FEV1. (SAFE). The Effect of Inhaled Tiotropium Bromide (18 mcg once daily) on the Change in FEV1 During Long-term Treatment in Patient with COPD. A One-year Parallel Group, Double-blind, Randomized, Placebo-controlled Study (replace |
Dr. Gerard (P.G.) Cox |
Dr. Stewart Pugsley |
|
02-2048 |
Asthma, Allergy, Diabetes and Atherosclerosis Birth Cohort |
Dr. Paul O'Byrne, Dr. Koon Teo, Dr. Salim Yusuf |
Dr. Katherine Morrison, Dr. Stephanie Atkinson, Dr. Sarah Capes, Dr. Judah Denburg, Dr. Pavel Hamet, Dr. Haresh Kirpalani, Dr. Matthew McQueen, Dr. Patrick Mohide, Dr. P. Pare, Dr. Andrew Sanford, Dr. Malcolm Sears |
|
01-1929 |
Relative potency in inhaled corticosteroids: validation of a clinical model - Protocol #FAS40032 |
Dr. Frederick Hargreave |
Dr. R. Hancox, Ms. Sarah Goodwin, Dr. Ann Efthimiadis |
|
01-2010 |
The effectiveness and safety of an individualised Symbicort Turbuhaler maintenance dosing regimen (Symbiocort Asthma Control Plan) versus Symbicort Turbuhaler given as regular twice daily therapy. |
Dr. Malcolm Sears |
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01-2011 |
A randomized, double-blind study to compare the safety and efficacy of 20mg of BAY 16-9996 versus placebo as adjunctive therapy for corticosteroid therapy in patients with severe asthma. |
Dr. Malcolm Sears |
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01-2005 |
Spontaneous sputum examination for inflammatory indices: time from expectoration to processing. |
Dr. Frederick Hargreave |
Dr. Ann Efthimiadis, Ms. .Cindy Goos |
|
01-1977 |
Identification of factors associated with seasonal increases in childhood admissions for asthma (Phase 3). |
Dr. Malcolm Sears |
Mr. Neil Johnston, Dr. Susan Waserman, Dr. Paul Keith, Dr. Madan Roy, Dr. Sebastian Johnston |
|
01-1956 |
Inhaled lidocaine: Efficacy in prednisone-dependent asthma. |
Dr. Frederick Hargreave |
Prof. Myrna Dolovich, Dr. D. Kloth |
|
01-1939 |
Investigation of LungAlert Values in patients with Lung Cancer and benign Lung Disease and in smokers. |
Dr. Gerard (P.G.) Cox, Dr. John D. Miller |
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|
00-1897 |
The feasibility of obtaining mRNA from lung and bronchial biopsy specimens using laser capture microdissection |
Dr. Gerard (P.G.) Cox |
|
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00-1853 |
Anti-inflammatory activity of roflumilast. Study on the efficacy of oral roflumilast (500ug/d) over 4 weeks on sputum eosinophils in patients with asthma. A double-blind randomized placebo-controlled parallel group study. |
Dr. Frederick Hargreave |
Dr. Parameswaran Nair, Dr. Ann Efthimiadis |
|
00-1839 |
Studies of airway smooth muscle cell biology in human disease. |
Dr. Gerard (P.G.) Cox |
Dr. Parameswaran Nair, Dr. Luke Janssen, Dr. Carl Richards |
|
00-1818 |
Comparison of inflammatory cells in bronchial biopsies in mild asthmatics and healthy controls. |
Dr. Frederick Hargreave |
Dr. John D. Miller |
|
99-1744 |
A cohort study of air quality and utilization of hospital services |
Dr. Malcolm Sears |
|
|
99-1709 |
Nasal allergen challenge: effects on airways of the lungs |
Dr. Frederick Hargreave |
|
|
05-2578 |
A randomized, open-label, parallel-group, international, multicenter study evaluating persistency of response to omalizumab during 32 weeks treatment given as add on to optimized asthma therapy in adult patients with severe persistent allergic asthma who |
Dr. Parameswaran Nair |
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06-2740 |
Measurement of lung ventilation in COPD using Hhe-3: correlation with disease severity |
Dr. Gerard (P.G.) Cox, Prof. Myrna Dolovich |
Dr. Michael Noseworthy |
|
08-3102 |
Predictors of beta-blocker-induced worsening of asthma |
Dr. Parameswaran Nair, Dr. Rebecca Amer |
Dr. Frederick Hargreave |
|
11-3517 |
Airway microbiome and whole-genome gene expression profile in patients with severe asthma |
Dr. Parameswaran Nair, Dr. Afia Aziz-ur-Rehman |
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11-3509 |
A 52 weeks, double blind, randomized, placebo-controlled trial evaluating the effect of oral BIBF 1120, 150 mg twice daily, on annual forced vital capacity decline, in patients with idiopathic pulmonary fibrosis (IPF) |
Dr. Martin Kolb |
Dr. Gerard (P.G.) Cox |
|
09-3212 |
Imaging of idiopathic pulmonary fibrosis with 18F-proline and PET pilot study |
Dr. Martin Kolb, Dr. Renee Labiris |
Dr. Karen Gulenchyn, Dr. Gerard (P.G.) Cox |
|
09-3171 |
Efficacy and safety of aclidinium bromide at two dose levels (200 mcg twice daily, 400 mcg twice daily) vs. placebo when administered to patients with moderate to severe chronic obstructive pulmonary disease (COPD) |
Dr. Andrew McIvor |
Dr. Gerard (P.G.) Cox |
|
04-2386 |
Studies of sputum cell biology in human disease |
Dr. Gerard (P.G.) Cox |