Health Research Methods, Evidence, and Impact

John (Jack) Sinclair

BA (Manitoba), BSc(Med) (Manitoba), MD (Manitoba)


Professor Emeritus, Pediatrics & Health Research Methods, Evidence, and Impact

905.521.2100 x 75611

McMaster University
Faculty of Health Sciences
1200 Main Street West,
Hamilton, Ontario, Canada
L8N 3Z5

Office location: HSC-3N11

Administrative Assistant: Dianne Haughton
905.521.2100 x 75611

An endowed chair has been created at McMaster to honour Dr. Sinclair's contributions
to the field of Neonatology.

Hamilton Health Sciences Foundation / Jack Sinclair Chair in Neonatology



Jack Sinclair is a neonatologist/clinical epidemiologist who is interested in the teaching and practice of evidence-based medicine. He is the founding editor of the Neonatal Collaborative Review Group of the Cochrane Collaboration, and is a member of the Cochrane Working Group on Levels of Evidence. He is interested in the role of evidence in making treatment recommendations, and in the ways in which beneficial and adverse effects of treatment can be best communicated.

Selected Publications

  1. Effective Care of the Newborn Infant ed. J.C. Sinclair and M. Bracken, Oxford University Press, 1992.
  2. Temperature Regulation & Energy Metabolism of the Newborn, ed. J.C. Sinclair, Grune & Stratton, New York, September, 1978.
  3. Guyatt GH, Sackett DL, Sinclair JC, Hayward R, Cook DJ, Cook RJ. Users' Guides to the Medical Literature. IX. A Method for Grading Health Care Recommendations. JAMA 1995;274(22):1800-1804.
  4. Sinclair JC, Bracken MB. Clinically useful measures of effect in binary analyses of randomized trials. J Clin Epidemiol 1994;87:881-889.
  5. The Canadian Preterm Labor Investigators Group (Sinclair JC: member of planning, steering, newborn followup committees). Treatment of threatened preterm delivery with the beta-adrenergic agonist ritodrine.New Engl J Med 1992; 327:308-12.
  6. Anderson, G.D., Blidner, I.N., McClemont, S., Sinclair, J.C.: Determinants of size at birth in a Canadian population. Am. J. Obstet. Gynecol. 150:236-244, 1984.
  7. Boyle, M.H., Torrance, G., Sinclair, J.C., Horwood, S.P.: Economic evaluation of neonatal intensive care of very low birth-weight infants. New Engl. J. Med. 308:1330-1337, 1983.
  8. Sinclair, J.C., Engel, K. and Silverman, W.A.: Early correction of hypoxemia and acidemia in infants of low birth weight - a controlled trial of oxygen breathing, rapid alkali infusion, and assisted ventilation. Pediatrics 42:565-589, 1968.
  9. Silverman, W.A., Sinclair, J.C. and Agate, F.J., Jr.: The oxygen cost of minor changes in heat balance of small newborn infants. Acta Paediat. Scand. 55:294-300, 1966.
  10. Sinclair, J.C. and Silverman, W.A.: Intrauterine growth in active tissue mass of the human fetus, with particular reference to the undergrown baby. Pediatrics 38:48-62, 1966.

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