Health Research Methods, Evidence, and Impact

David Meyre

David Meyre

PhD (France)

Associate Professor, Dept of Health Research Methods, Evidence, and Impact

Joint Member, Department of Pathology & Molecular Medicine

Member: Population Genomics Program

McMaster University
Michael DeGroote Centre for Learning & Discovery, Room 3205
905.525.9140 x 26802
meyred@mcmaster.ca

Assistant: Carolina Stryjecki
tempasst@mcmaster.ca

 

Lab website: www.davidmeyrelab.com

Currently accepting Undergraduate (ideally students entering 3rd year) and Graduate students

 

Academic Interests

David Meyre completed a PhD in quantitative plant genetics in France. Since 2001, he has been working on the elucidation of the genetic bases of obesity and type 2 diabetes. In 2004, he published the first family-based genome-wide scans for childhood and severe adult obesity, which identified significant regions for linkage on chromosome 5q and 6q. He completed the two first successful positional cloning efforts for childhood and severe adult obesity, which identified the positional candidate genes ENPP1 and PCSK1. In 2007, he contributed to the identification of the major susceptibility gene for polygenic obesity FTO, the in 2007. The same year, David Meyre was part of the team who published the first genome-wide association study in complex diseases. In 2009, David Meyre published the first genome-wide association study of extreme obesity in the French population and identified four novel susceptibility-loci. In 2010, he conducted the first genome-wide association meta-analysis for early-onset extreme obesity in German and French populations, leading to the identification of two novel childhood obesity predisposing loci. In 2012, he identified the third more common form of monogenic obesity (PCSK1 partial deficiency) and demonstrated an important role of the lipid sensor GPR120 in human obesity. He also discovered the first molecular link between obesity and major depression. In 2013, he contributed to the identification of seven novel loci contributing to adult obesity in a study including more than 260,000 people, and discovered a novel gene (SIM1) responsible for a syndromic Mendelian form of childhood obesity. In 2014, he identified that blood glucose level one hour after an oral glucose tolerance test is the stronger predictor to date of incident risk of type 2 diabetes. In 2015, he contributed to develop a tool (Q-Genie) to optimize meta-analyses of genetic association studies and published the larger meta-analysis to date in the field of genetic epidemiology by using innovative data extraction methods. In 2016, he discovered that physical activity can blunt the effect of the obesity predisposing gene FTO in diverse ethnic groups. He also demonstrated that genes can predict the outcomes of different types of bariatric surgery.

With 164 articles published up to date (94 appeared in top-tier journals including Nature, Science, Nature Genetics...), 17,400 citations and a H-index of 53, Dr Meyre is an international expert in genetic epidemiology of obesity and type 2 diabetes. Dr Meyre is developing a multidisciplinary obesity genetic research program at McMaster University to provide an exhaustive picture of the etiology of this complex disorder and to equip the decision makers with the appropriate tools in order to tackle obesity and its complications worldwide. His current research interests include 1) gene identification in diverse ethnic groups 2) gene x environment interactions 3) epigenetics 4) evolutionary genetics 5) molecular physiology 6) systems biology 7) development of new methods and guidelines 8) knowledge synthesis 9) knowledge translation and 10) evidence-based personalized prevention and medicine.

Selected Publications

  1. Li A, Teo KK, Morrison KM, McDonald SD, Atkinson SA, Anand SS, Meyre D. A genetic link between prepregnancy body mass index, postpartum weight retention, and offspring weight in early childhood. Obesity (Silver Spring). 2017 Jan;25(1):236-243
  2. Li A, Robiou-du-Pont S, Anand SS, Morrison KM, McDonald SD, Atkinson SA, Teo KK, Meyre D. Parental and child genetic contributions to obesity traits in early life based on 83 loci validated in adults: the FAMILY study. Pediatr Obes. 2016 Dec 23.
  3. Langlois C, Abadi A, Peralta-Romero J, Alyass A, Suarez F, Gomez-Zamudio J, Burguete-Garcia AI, Yazdi FT, Cruz M, Meyre D. Evaluating the transferability of 15 European-derived fasting plasma glucose SNPs in Mexican children and adolescents. Sci Rep. 2016 Oct 26;6:36202.
  4. Reddon H, Guéant JL, Meyre D. The importance of gene-environment interactions in human obesity. Clin Sci (Lond). 2016 Sep 1;130(18):1571-97.
  5. Abadi A, Peralta-Romero J, Suarez F, Gomez-Zamudio J, Burguete-Garcia AI, Cruz M, Meyre D. Assessing the effects of 35 European-derived BMI-associated SNPs in Mexican children. Obesity (Silver Spring). 2016 Sep;24(9):1989-95.
  6. Ishola AF, Gerstein HC, Engert JC, Mohan V, Diaz R, Anand SS, Meyre D. Longitudinal relationships between glycemic status and body mass index in a multiethnic study: evidence from observational and genetic epidemiology. Sci Rep. 2016 Aug 2;6:30744.
  7. Pigeyre M, Yazdi FT, Kaur Y, Meyre D. Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity. Clin Sci (Lond). 2016 Jun 1;130(12):943-86.
  8. Stryjecki C, Peralta-Romero J, Alyass A, Karam-Araujo R, Suarez F, Gomez-Zamudio J, Burguete-Garcia A, Cruz M, Meyre D. Association between PPAR-γ2 Pro12Ala genotype and insulin resistance is modified by circulating lipids in Mexican children. Sci Rep. 2016 Apr 14;6:24472.
  9. Sohani ZN, Anand SS, Robiou-du-Pont S, Morrison KM, McDonald SD, Atkinson SA, Teo KK, Meyre D. Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study. PLoS One. 2016 Apr 6;11(4):e0152107.
  10. Reddon H, Gerstein HC, Engert JC, Mohan V, Bosch J, Desai D, Bailey SD, Diaz R, Yusuf S, Anand SS, Meyre D. Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study. Sci Rep. 2016 Jan 4;6:18672.

Search for citations for Dr. Meyre on PubMed