Health Research Methods, Evidence, and Impact

Haresh Kirpalani

MD (Southampton), MSc (McMaster), FRCS, MRCP, FRCPC, FRCP

Professor Emeritus, Department of Pediatrics

Associate Member, Dept of Health Research Methods, Evidence, and Impact

905.521.2100 x 40748

Neonatal Trials Group
DBCVSRI Level 4, C4-109
Hamilton General Hospital Campus
237 Barton Street East
Hamilton, ON  L8L 2X2

Academic Interests

Dr. Kirpalani trained as a pediatrician in the UK and has been a staff neonatologist in Canada since 1983. Nationally, he was appointed to the Fetus and Newborn Committee of the Canadian Pediatric Society in 2003, & since fall 2003, sits on the RCT panel of CIHR. One broad research interest has been to improve the management of neonatal lung disease. He has assessed aerosol drug delivery in animal models, and the airways of human newborns. Currently he is studying ventilation strategies to optimize lung volumes. Another broad research theme is parental counseling and pediatric HRQL & Parental Hope. He developed an instrument to measure disease-specific HRQL in spina bifida; and showed that Parental Hope is an important determinant of the quality of life of these children, outweighing “biological” determinants related to the level of spinal cord involvement at birth. A final theme has been large-scale randomised trials. He has been on the steering committees of several multi-centre clinical trials, including two MRC-NIH funded studies of inhaled nitric oxide for mature infants with pulmonary hypertension. Currently, he is a co-PI (with Dr R.Whyte, Halifax) an international trial of transfusion practice in newborns (Prematures in Need of Transfusion PINT – CIHR funded), now completing data analysis. He sits on the steering committee of the Canadian led international trial on cooling in children with severe head injury. A new area of research interest is how corporatisation has adversely affected academic and clinical freedom. Additionally, Haresh has co-edited 2 popular books: “Residents Handbook of Neonatology”; Perlman, Kirpalani, Moore, eds. (BC. Decker 1999; ISBN: 1-55009-071-2); and Kirpalani, Mernagh, Gill, eds. “Imaging of the Newborn Baby”; (Churchill Livingstone 1999; ISBN 0-443-05544-0). Both are entering new editions & he is also completing a “Residents Handbook of Pediatric ICU” (BC Decker).

Selected Publications

  1. Turk J, Kirpalani H, Guyatt G. Has the Corporatisation of Canadian Health Care Affected Academic Freedom? Royal Colleges Outlook, January Winter 2005.
  2. Andersen C, Kent A, Schmidt B, Nahmias C, deSa D, Bourgeois J, Xing Z, Kirpalani H. Pulmonary fluorodeoxyglucose uptake in infants of very low birth weight with and without intrauterine inflammation. J Pediatr. 2003 Oct;143(4):470-6.
  3. Zupancic JA, Kirpalani H, Barrett J, Stewart S, Gafni A, Streiner D, Beecroft ML, Smith P. Characterising doctor-parent communication in counselling for impending preterm delivery. Arch Dis Child Fetal Neonatal Ed. 2002 Sep;87(2):F113-7.
  4. Kirpalani HM, Parkin PC, Willan AR, Fehlings DL, Rosenbaum PL, King D, Van Nie AJ. Quality of life in spina bifida: importance of parental hope. Arch Dis Child. 2000 Oct;83(4):293-7. 93
  5. Matlow AG, Kitai I, Kirpalani H, Chapman NH, Corey M, Perlman M, Pencharz P, Jewell S, Phillips-Gordon C, Summerbell R, Ford-Jones EL A randomized trial of 72- versus 24-hour intravenous tubing set changes in newborns receiving lipid therapy. Infect Control Hosp Epidemiol. 1999 Jul;20(7):487-93.
  6. Kirpalani H, Abubakar K, Nahmias C, deSa D, Coates G, Schmidt B. [18F]fluorodeoxyglucose uptake in neonatal acute lung injury measured by positron emission tomography. Pediatr Res. 1997 Jun;41(6):892-6.

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