Clinical Epidemiology & Biostatistics

PJ Devereaux

MD (Dalhousie), PhD (McMaster) FRCPC

Associate Professor, Department of Clinical Epidemiology and Biostatistics

Joint Member, Department of Medicine (Cardiology)

Member, CLARITY (Clinical Advances Through Research and Information Translation)

Member, Population Health Research Institute

Heart and Stroke Foundation of Ontario Career Investigator Award to pursue research in major vascular complications after non-cardiac surgery

Attending Staff, Hamilton Health Sciences, Cardiac Care Unit

905.527.4322 x 40654

McMaster University
Faculty of Health Sciences
1280 Main Street West, Rm. 2C12
Hamilton, Ontario, Canada
L8S 4K1

Office location: HSC-2C12

Administrative Coordinator: Heather Gill
905.527.4322 x40654


Academic Interests

Dr. Devereaux obtained his MD from McMaster University.  After medical school he completed a residency in internal medicine at the University of Calgary and a residency in cardiology at Dalhousie University.  He then completed a PhD in Clinical Epidemiology at McMaster University.  Dr. Devereaux holds a Heart and Stroke Foundation of Ontario Career Investigator Award.   He was the Co-PI of the POISE-1 Trial, the world’s largest cardiac randomized controlled trial in patients undergoing noncardiac surgery.  Dr. Devereaux is the PI of the VISION Study that evaluated major vascular complications in a representative sample of 40,000 patients undergoing noncardiac surgery in 14 centres in 10 countries.  He is also the PI of the POISE-2 Trial that evaluated the effects of clonidine versus placebo and ASA versus placebo in a factorial 10,000 patient trial among patients undergoing noncardiac surgery.  Dr. Devereaux has published over 180 peer reviewed papers and 40 editorials, book chapters and commentaries.  He is currently the Head of Cardiology and the Perioperative Medicine Program at the Juravinski Hospital and Cancer Centre.  He is also the Scientific Leader of the Perioperative Medicine and Surgical Research Group at the Population Health Research Institute. 

Selected Publications

  1. Devereaux PJ, Guyatt G, Yang H and Yusuf S for the POISE investigators. The Perioperative Ischemic Evaluation (POISE) Trial: the effects of a perioperative β-blocker in patients undergoing noncardiac surgery. CMAJ 2011; 183: E351-E353.
  2. Devereaux PJ, Xavier D, Pogue J, Guyatt G, Sigamani A, Garutti I, Leslie K, Rao-Melacini P, Chrolavicius S, Yang H, MacDonald C, Avezum A, Lanthier L, Hu W, Yusuf S, on behalf of the POISE (PeriOperative ISchemic Evaluation) Investigators. Characteristics and short-term prognosis of perioperative myocardial infarction in patients undergoing noncardiac surgery. Ann Intern Med. 2011; 154: 523-528.
  3. Levy M, Heels-Ansdell D, Hiralal R, Bhandari M, Guyatt G, Yusuf S, Cook D, Villar JC, McQueen M, McFalls E, Filipovic M, Schünemann H, Sear J, Foex P, Lim W, Landesberg G, Godet G, Poldermans D, Bursi F, Kertai M, Bhatnagar B, Devereaux PJ.  Prognostic value of troponin and creatine kinase muscle and brain isoenzyme measurement after noncardiac surgery: A systematic review and meta-analysis. Anesthesiology. 2011; 114: 796-806.
  4. Simunovic N, Devereaux PJ, Sprague S, Guyatt GH, Schemitsch EH, deBeer J, Bhandari M. Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis. CMAJ. 2010; 182: 1609-1616.
  5. Moher D, Hopewell S, Schulz KF, Montori V, Gøtzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG.  CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials. BMJ. 2010; PMID: 20332511; J Clin Epidemiol. 2010; PMID: 20346624.
  6. Karthikeyan G, Moncur RA, Levine O, Heels-Ansdell D, Chan MTV, Alonso-Coello P, Yusuf S, Sessler D, Villar JC, Berwanger O, McQueen M, Mathew A, Hill S, Gibson S, Berry C, Yeh H-M, Devereaux PJ.  Is a preoperative brain natriuretic peptide or N-terminal pro-B type natriuretic peptide measurement an independent predictor of adverse cardiovascular outcomes within 30 days of noncardiac surgery? A systematic review and meta-analysis of observational studies.  J Am Coll Cardiol. 2009; 54:1599-1606.
  7. Liberati A, Altman D, Tetzlaff JM, Mulrow C, Goetzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D.  The PRISMA Statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med. 2009; 151: W65-94; J Clin Epidemiol. 2009; PMID: 19631507; BMJ. 2009; PMID: 196225522; PloS Med. 2009: PMID: 19621070
  8. The POISE Study Group (Devereaux PJ writing committee chair) Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial.  Lancet 2008; 371: 1839-1847. (fast-tracked article)
  9. Xavier D, Pais P, Devereaux PJ, Xie C, Prabhakaran D, Reddy KS, Gupta R, Joshi P, Kerkar P, Thanikachalam S, Haridas KK, Jaison TM, Naik S, Maity AK, Yusuf S. Treatment and outcomes of acute coronary syndromes in India (CREATE):  A prospective analysis of registry data.  Lancet 2008; 371: 1435-1442.
  10. Devereaux PJ, Beattie WS, Choi PTL, Badner NH, Guyatt GH, Villar JC, Cinà CS, Leslie K, Jacka MJ, Montori VM, Bhandari M, Avezum A, Biasi Cavalcante A, Giles JW, Schricker T, Yang H, Jackobsen CJ, Yusuf S. How strong is the evidence for the use of perioperative ß-blockers in non-cardiac surgery? A systematic review and meta-analysis of randomised controlled trials. BMJ. 2005; 331: 313-321.

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