Health Research Methods, Evidence, and Impact

Russell de Souza

BA (Queens), BASc (Ryerson), MSc (Toronto), ScD (Harvard)

Assistant Professor, Department of Health Research Methods, Evidence, and Impact

905 525-9140 x 22109

Department of Health Research Methods, Evidence, and Impact
1200 Main St. West
Hamilton, ON L8N 3Z5


Academic Interests

Dr. de Souza is a registered dietitian and nutrition epidemiologist.  His current research interests lie in advancing methodology for systematic reviews and meta-analysis and clinical trials in the field of nutrition,  with an interest in the contribution of dietary patterns and macronutrients (specifically fructose, saturated and trans fats) to cardiovascular disease risk throughout the lifespan.  He is a co-investigator on the INMD-funded Birth Cohort Alliance, which seeks to explore associations among maternal nutrition, infant feeding patterns, and epigenetic/epigenomic determinants of maternal and child health; and the Alliance for Health Hearts and Minds cohort examining neighborhood-level factors that contribute to cardiovascular risk.  He is also interested in the reproducibility and validity of current methods of assessing nutrient intakes.


Post-doctoral fellows
Dr. Michael Zulyniak

PhD students
Vanessa Ha

Undergraduate students
Yuvreet Kaur

Selected Publications

  1. Ha V, Sievenpiper JL, de Souza RJ, Jayalath VH, Mirrahimi A, Agarwal A, Chiavaroli L, Mejia SB, Sacks FM, Di Buono M, Bernstein AM, Leiter LA, Kris-Etherton PM, Vuksan V, Bazinet RP, Josse RG, Beyene J, Kendall CW, Jenkins DJ.  Effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction: a systematic review and meta-analysis of randomized controlled trials.  CMAJ. 2014 May 13;186(8):E252-62. doi: 10.1503/cmaj.131727. Epub 2014 Apr 7.  PMID:  24710915
  2. Rana A*, de Souza R*, Kandasamy S, Lear S, Anand SS.  Cardiovascular risk in South Asians living in Canada:  A systematic review.  CMAJ Open.   5-May 2014 (in press)
  3. Jayalath VH, de Souza RJ, Sievenpiper JL, Ha V, Chiavaroli L, Mirrahimi A, Di Buono M, Bernstein AM, Leiter LA, Kris-Etherton PM, Vuksan V, Beyene J, Kendall CW, Jenkins DJ. Effect of Dietary Pulses on Blood Pressure: A Systematic Review and Meta-analysis of Controlled Feeding Trials. Am J Hypertens. 2014 Jan;27(1):56-64. doi: 10.1093/ajh/hpt155. Epub 2013 Sep 7.
  4. Mirrahimi  A, de Souza RJ, Chiavaroli L, Sievenpiper JL,  Beyene J,  Hanley AJ,  Augustin LSA, Kendall CWC, Jenkins DJA.  Associations of Glycemic Index and Load With Coronary Heart Disease Events: A Systematic Review and Meta-Analysis of Prospective Cohorts.  J Am Heart Assoc. 2012;1:published online October 12, 2012
  5. Jenkins DJ, Kendall CW, Augustin LS, Mitchell S, Sahye-Pudaruth S, Blanco Mejia S, Chiavaroli L, Mirrahimi A, Ireland C, Bashyam B, Vidgen E, de Souza RJ, Sievenpiper JL, Coveney J, Leiter LA, Josse RG. Effect of Legumes as Part of a Low Glycemic Index Diet on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes Mellitus: A Randomized Controlled Trial. Arch Intern Med. 2012 Oct 22:1-8. [Epub ahead of print]
  6. Sievenpiper JL, de Souza RJ, Mirrahimi A, Yu ME, Carleton AJ, Beyene J, Chiavaroli L, Di Buono M, Jenkins AL, Leiter LA, Wolever TM, Kendall CW, Jenkins DJ.  Effect of Fructose on Body Weight in Controlled Feeding Trials: A Systematic Review and Meta-analysis.  Ann Intern Med. 2012 Feb 21;156(4):291-304.
  7. de Souza RJ, Bray GA, Carey VJ, Hall KD, Leboff MS, Loria CM, Laranjo NM, Sacks FM, Smith SR.  Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial. Am J Clin Nutr. 2012 Jan 18. [Epub ahead of print]
  8. Jenkins DJ, Jones PJ, Lamarche B, Kendall CW, Faulkner D, Cermakova L, Gigleux I, Ramprasath V, de Souza R, Ireland C, Patel D, Srichaikul K, Abdulnour S, Bashyam B, Collier C, Hoshizaki S, Josse RG, Leiter LA, Connelly PW, Frohlich J. Effect of a dietary portfolio of cholesterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia: a randomized controlled trial. JAMA. 2011 Aug 24;306(8):831-9.
  9. Griesdale DE, de Souza RJ, van Dam RM, Heyland DK, Cook DJ, Malhotra A, Dhaliwal R, Henderson WR, Chittock DR, Finfer S, Talmor D.  Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data.  CMAJ. 2009 Apr 14;180(8):821-7; discussion 799-800. Epub 2009 Mar 24.
  10. de Souza RJ, Swain JF, Appel LJ, Sacks FM.  Alternatives for macronutrient intake and chronic disease: a comparison of the OmniHeart diets with popular diets and with dietary recommendations. Am J Clin Nutr. 2008 Jul;88(1):1-11.

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