Health Research Methods, Evidence, and Impact

Matthias Briel

PhD (Freiburg, Germany), MSc (Hamilton)

Assistant Professor (Part-time), Dept of Health Research Methods, Evidence, and Impact

+41 61 265 3108
+41 61 265 3109

Basel Institute for Clinical Epidemiology and Biostatistics,
University Hospital Basel,
Hebelstrasse 10
4031 Basel


Academic Interests

Dr. Briel's research interests include methodologic and applied aspects of randomized controlled trials, systematic reviews and meta-analyses of aggregate and individual patient data. He is the principal investigator of an international multicentre study examining discontinued trials by means of documents from research ethics committees and corresponding publications. Dr. Briel is further interested in the dissemination of concepts of evidence-based medicine and teaches clinical research methodology in Hamilton and Basel.

Selected Publications

  1. Briel M, Langewitz W, Tschudi P, Young J, Hugenschmidt C, Bucher HC. Communication training and antibiotic use in acute respiratory tract infections: a cluster randomised controlled trial in general practice. Swiss Med Weekly 2006;136(15-16):241-247
  2. Briel M, Schwartz GG, Thompson PL, et al. Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: a meta-analysis of randomized controlled trials. JAMA 2006;295(17):2046-56
  3. Briel M, Young J, Tschudi P, Hugenschmidt C, Bucher HC, Langewitz W. Shared-decision making in general practice: Do patients with respiratory tract infections actually want it? Swiss Med Weekly 2007;137:483-485
  4. Briel M, Schuetz P, Mueller B, Young J, Schild U, Nusbaumer C, Périat P, Bucher HC, Crist-Crain M. Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory infections in primary care. Arch Intern Med 2008;168(18):2000-2007
  5. Briel M, Ferreira-Gonzalez I, You JJ, et al. Association between change in high-density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis. BMJ 2009;338:b92

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