McMaster University

McMaster University



Ray Truant

Ray Truant, PhD

Biochemistry and Biomedical Sciences

4N54 Health Sciences Centre
McMaster University
905-525-9140 ext. 22450

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  • Cell Biology and Regulation

Our laboratory is interested in how proteins move throughout the cell's organelles in humans. We have successfully implemented and developed new tools to look at how proteins move within live cells. We are also interested in the discovery of new protein-protein interactions by biochemical methods in vitro, and analysing these interactions in living cells in vivo. We are currently focusing our research on a series of genetically inherited neurodegenerative diseases that all have one basic biochemical defect in common: CAG DNA sequences >36 repeats in the gene's open reading frame that translate to glutamine amino acid stretches in the disease protein. These diseases are collectively referred to as Polyglutamine expansion diseases and include SBMA, DRPLA, HD, SCAs 1,2,3,6,7 and 17.

We are actively involved in trying to determine the normal functions of huntingtin and what the overall biological role of huntingtin is in every living human cell, and how mutant huntingtin exactly leads to Huntington?s disease (HD).

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