Biochemistry and Biomedical Sciences
4N54 Health Sciences Centre
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- Cell Biology and Regulation
Our laboratory is interested in how proteins move throughout the cell's
organelles in humans. We have successfully implemented and developed new tools
to look at how proteins move within live cells. We are also interested in the
discovery of new protein-protein interactions by biochemical methods in vitro,
and analysing these interactions in living cells in vivo. We are currently
focusing our research on a series of genetically inherited neurodegenerative
diseases that all have one basic biochemical defect in common: CAG DNA sequences >36 repeats in the gene's open reading frame that translate to glutamine
amino acid stretches in the disease protein. These diseases are collectively
referred to as Polyglutamine expansion diseases and include SBMA, DRPLA, HD, SCAs 1,2,3,6,7 and 17.
We are actively involved in trying to determine the normal functions of
huntingtin and what the overall biological role of huntingtin is in every living
human cell, and how mutant huntingtin exactly leads to Huntington?s disease (HD).