McMaster University

McMaster University



Lesley MacNeil

Lesley T. MacNeil, PhD

Assistant Professor, Department of Biochemistry and Biomedical Sciences

Farncombe Family Digestive Health Research Institute

Office: HSC 4H17
Extension: 26523

Lab: HSC 3N11B
Extension: 21256


  • C. elegans research
  • Diet, metabolism and microbiota
  • Gene-environment interactions

Using the nematode C. elegansas a model system, the MacNeil lab investigates the mechanisms by which environmental factors, specifically diet and microbiota, influence health, development, disease susceptibility, and disease progression. Currently, we are examining how these factors affect age-related disorders such as neurodegeneration. In addition to these specific disease models, we are employing
high-throughput approaches to perform genome-scale mapping of gene-environment interactions to
identify gene mutations that increase susceptibility to specific environmental factors.


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