Biochemistry and Biomedical Sciences
4H28 Health Sciences Centre
905-525-9140 ext. 22073
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- Cell Biology and Regulation
Our laboratory is interested in the structure and properties of biological membranes. Many cell processes are intimately linked to membranes. These include most signal transduction phenomena, the entry of viruses into target cells, as well as the action of many drugs and cytotoxic agents. We are involved in several studies elucidating the molecular properties of membranes. These include the mechanism of viral fusion and the function of viral fusion proteins; the distribution of cholesterol in membranes and the role of proteins in sequestering cholesterol-rich domains; the role of lipids in signal transduction; the mechanism of action of antimicrobial peptides and the phenomenon of membrane lysis by different agents leading to cell death. In all of these areas, there is a focus in understanding the relationship between membrane molecular properties and the essential functions of the cell.